Preparation method of triazole derivative

A technology of triazole derivatives and compounds, which is applied in the field of new preparation of pharmaceutical intermediates, and can solve problems such as difficult synthesis
CN104844528AInactive Publication Date: 2015-08-19湖南华腾制药有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
湖南华腾制药有限公司
Publication Date
2015-08-19
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a preparation method of a triazole derivative N-((5-(4-bromophenyl)-2H-1,2,4-triazole-3-yl)methyl)-N-propyl-1-propylamine. According to the preparation method, 3-(4-bromophenyl) ethyl acrylate is taken as the starting raw material, and the starting raw material is enabled to go through reduction, acylation, imidization, ring closing, Boc removal and alkylation reaction, and then the target product 7 can be obtained; the product is taken as a template micromolecule to synthesize diverse compound libraries.
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Description

technical field

[0001] The present invention relates to a novel preparation method of a pharmaceutical intermediate, in particular to a triazole derivative N-((5-(4-bromophenyl)-2H-1,2,4-triazol-3-yl) The preparation method of methyl)-N-propyl propan-1-amine. technical background

[0002] Compound N-((5-(4-bromophenyl)-2H-1,2,4-triazol-3-yl)methyl)-N-propylpropan-1-amine, the structural formula is:

[0003]

[0004] The compound N-((5-(4-bromophenyl)-2H-1,2,4-triazol-3-yl)methyl)-N-propylpropan-1-amine and related derivatives in It is widely used in medicinal chemistry and organic synthesis. Currently, the synthesis of N-((5-(4-bromophenyl)-2H-1,2,4-triazol-3-yl)methyl)-N-propylpropan-1-amine is difficult. Therefore, it is necessary to develop a synthetic method with easy-to-obtain raw materials, convenient operation, easy-to-control reaction and suitable overall yield. Contents of the invention

[0005] The invention discloses a triazole compound N-((5-(4-bromophen...

Claims

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