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174 results about "Propylamines" patented technology
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Derivatives of propylamine (the structural formula NH2CH2CH2CH3).
A kind of synthetic method of telamectin
ActiveCN102295672ALow costSimple methodSugar derivativesSugar derivatives preparationEpoxyAzithromycin
The present invention relates to the technical fields of organic chemistry and pharmaceutical chemistry, concretely discloses a synthetic method for a known compound tylosin. The synthetic method comprises the following steps: taking Azithromycin A as a raw material, the protected Azithromycin A can be obtained by Cbz-Cl and then oxidized through a modified Pfitznor-Moffat method, the protected ketone by Cbz can be obtained, ketone is reacted through Wittig-Horner, keto is conversed into alkenyl to obtain the protected alkene, the protected alkene is oxidized to obtain an epoxy compound protected by Cbz, the epoxy compound protected by Cbz is deprotected to obtain a deprotected epoxy compound under the catalysis of Pd / C, the deprotected epoxy compound is reacted with n-propylamine and is performed a ring-opening to obtain a tylosin crude product, the tylosin crude product and acid are carried out a salt forming and purifying, then tylosin can be obtained by resolving. The synthetic route is changed by the method of the invention, the super low-temperature is not employed in the route, and the tylosin enables the effective industrialization production.
Owner:武汉回盛生物科技股份有限公司
A new method for preparing telamycin
ActiveCN102260306AAvoid catalytic hydrogenation methodsReduce manufacturing costSugar derivativesSugar derivatives preparationEpoxyAzithromycin
The invention discloses a novel method for preparing tulathromycin and relates to a semi-synthetic macrolide antibiotic. The method comprises the following steps: simultaneously protecting 2'-hydroxyl and 6a-amino of desmethyl azithromycin with acetyl, then carrying out oxidation and epoxidation on 4''-hydroxy, then removing the protecting groups under alkaline alcohol solution conditions, and carrying out nucleophilic addition on 4''-epoxy group with n-propylamine to obtain the target compound tulathromycin. Compared with the prior art, the method for preparing tulathromycin has the advantages of simple process, mild conditions, high yield and the like, and is beneficial to industrial production.
Owner:SHANDONG LUKANG SHELILE PHARMA
Process for the preparation of N-alkyl-N-methyl-3-hydroxy-3-(2-thienyl)-propylamines
InactiveUS20050197503A1High chemical purityHigh optical purityOrganic chemistryPropylamineAsymmetric hydrogenation
The present invention relates to an improved process for preparing chiral N-substituted N-methyl-3-hydroxy-3-(2-thienyl)-propylamine on an industrial scale using an asymmetric hydrogenation as a key step and optionally a special sequence of subsequent steps, using a catalyst system consisting of rhodium and (2R, 4R)-4-(dicyclohexylphosphino)-2-(diphenyl-phosphino-methyl)-N-methyl-aminocarbonyl-pyrrolidine.
Owner:BOEHRINGER INGELHEIM INT GMBH
Low-toxicity functionalized quantum dot modified by amination beta-cyclodextrin and preparation method thereof
InactiveCN102220128AGood low toxicityFluorescence/phosphorescenceLuminescent compositionsSolubilityFluorescence
The invention relates to a low-toxicity functionalized quantum dot modified by amination beta-cyclodextrin and a preparation method thereof, belonging to the field of a special molecular recognition and diagnosis reagent. The method comprises the following steps that functional-group amino is connected on beta-cyclodextrin by a chemical modification method to obtain amino-group-beta-cyclodextrin;under the action of 1-ethyl-3-(3-dimethyl propylamine) carbodiimide hydrochloride and N-hydroxysuccinimide, amino-group-beta-cyclodextrin is coupled with folic acid to obtain folic acid-beta-cyclodextrin; and by taking silver, zinc and other low-toxicity elements as raw materials, an oil-solubility near-infrared quantum dot is prepared, and folic acid-Beta-cyclodextrin is used to carry out water-solubility modification to the oil-solubility near-infrared quantum dot so as to obtain the low-toxicity functionalized quantum dot modified by amination beta-cyclodextrin. The quantum dot has good water-solubility and low-toxicity; and as emission spectrum is in a near-infrared area, and the folic acid is coupled, the quantum dot can be used for special fluorescence detection of tumors.
Owner:江苏迈健生物科技发展股份有限公司
CuCe-SAPO-34 molecular sieve catalyst, as well as preparation method and use thereof
InactiveCN104888851ANo ion exchange step requiredReduce generationMolecular sieve catalystsDispersed particle separationGas phaseCerium
The invention provides a CuCe-SAPO-34 molecular sieve catalyst, as well as a preparation method and use thereof. The method comprises the following steps: adding pseudo-boehmite in deionized water, stirring, then adding ortho-phosphoric acid and fumed silica, uniformly mixing, then adding copper salt and tetraethylenepentamine, sufficiently mixing, adding cerate and n-propylamine, loading the completely mixed gel in a hydrothermal reaction kettle to crystallize, cooling at room temperature, separating the solid crystallized product from the mother liquor, washing to neutral, drying, and roasting in air to obtain the CuCe-SAPO-34 molecular sieve catalyst. The CuCe-SAPO-34 molecular sieve catalyst is prepared through the adoption of the hydrothermal synthesis method, and the molecular sieve catalyst with excellent NH3-SCR catalytic activity and water resistance is obtained by adjusting the loading amount of cerium through the control of the input of the cerate.
Owner:RES CENT FOR ECO ENVIRONMENTAL SCI THE CHINESE ACAD OF SCI
Preparation method for hydroxylapatite hydrogel used for bone regeneration
The invention relates to a preparation method for a hydroxylapatite hydrogel used for bone regeneration. The preparation method comprises (1) a step of adding hydroxylapatite into an organic solvent, adding n-propylamine and a coupling agent, performing a reaction at 50-80 DEG C for 30-240 min to obtain a hydroxylapatite mixed solution, cooling to 10-30 DEG C after the reaction is finished, washing with washing liquid, and drying to obtain functional hydroxylapatite powder; and (2) a step of homogenously dispersing the functional hydroxylapatite powder, hydrophilic monomers, an initiator and a catalyst into a water solution to obtain hydrogel prepolymerization liquid, and then performing polymerization at 0-40 DEG C for 24-72 h to obtain the hydroxylapatite hydrogel used for bone regeneration. The preparation method is simple in technology and low in cost. The hydroxylapatite is homogenously dispersed in the hydrogel matrix. The hydroxylapatite hydrogel, as a tissue engineering implant material, can induce bone growth and promote bone healing, and has high application value.
Owner:DONGHUA UNIV
Preparation method of tulathromycin
ActiveCN106939029AImprove protectionAvoid catalytic hydrogenation methodsSugar derivativesSugar derivatives preparationAzithromycinChemical synthesis
The invention relates to the field of chemical synthesis and particularly relates to a preparation method of tulathromycin. The method comprises protecting a 2-hydroxyl group of demethyl azithromycin through 4-nitrobenzyl chloroformate, carrying out oxidation and epoxidation on a 4"-hydroxyl group, and carrying out deprotection and 4"-epoxy nucleophilic addition through n-propylamine to obtain tulathromycin. Comprised with the prior art, the preparation method has simple processes, mild conditions and a high yield, is free of palladium-carbon hydrodeprotection and is conducive to industrial production.
Owner:AMICOGEN CHINA BIOPHARM CO LTD
Preparation of N,N-dimethyl-1-phenyl-3-(1-naphthoxy) propanamine
InactiveCN101367739ANon-toxicShort synthetic routeOrganic compound preparationAmino-hyroxy compound preparationChemical industry1-Naphthol
The present invention provides a preparation technology of N, N-dimethyl-1-benzyl-3-(1-naphthyloxies) propylamine, and belongs to the technical field of medical and chemical industry. The present invention solves the problems that the prior synthesis route is long, and the high toxicity, explosiveness, sources or byproducts of raw materials are hard to control. In the preparation technology of the N, N-dimethyl-1-benzyl-3-(1-naphthyloxies) propylamine, 3-chlorine-1-phenyl propanone is used as a starting raw material and is condensed with 1-naphthol, and the N, N-dimethyl-1-benzyl-3-(1-naphthyloxies) propylamine can be prepared through amination, reduction and methylation. The present invention has the advantages that the synthesis route is shortened, and the cost is reduced.
Owner:TAIZHOU VOCATIONAL & TECHN COLLEGE
Flame-retardant polyethylene-polypropylene composite plastic
The invention discloses a flame-retardant polyethylene-polypropylene composite plastic and particularly relates to the field of preparation of a plastic formula. The flame-retardant polyethylene-polypropylene composite plastic includes following components, by weight, polyethylene, polyvinyl chloride, dimethylamino propylamine, melamine, antimony oxide, glycerol triacetate, an anti-oxidant, benzophenone, ammonium polyphosphate, triphenyl triphosphate and glass fibers. The composite plastic is high in mechanical strength, is good in flame-retardant performance, is excellent in corrosion-resistant performance and anti-static performance, is low in cost and is long in service life.
Owner:QINGDAO DTCN NEW MATERIAL TECH DEV
A kind of synthetic method of Erecoxib
ActiveCN104193664BHarm reductionThe reaction steps are simpleOrganic chemistry2-PyrrolidoneDrugs synthesis
The invention discloses a synthesis method of imrecoxib and belongs to the field of drug synthesis. The method comprises the following steps: reacting p-toluene acetyl halide with propylamine to produce a compound III p-toluene levulinic amine; reacting the compound III with p-methylsulfonyl chloroacetophenone under an alkaline condition to produce a compound V; and then cyclizing to obtain a compound VII, namely n-propyl-3-(4-methyl phenyl)-4-(4-methylsulfonyl phenyl)-2,5-dihydro-1H-2-pyrrolidone. The method disclosed by the invention comprises simple reaction steps and can be put into industrial production easily.
Owner:SHANDONG BOYUAN PHARM CO LTD
Method for producing bactericide prochloraz
The invention relates to a method for industrially producing disinfecting agent prochloraz, which is characterized by comprising the following steps: 2, 4, 6-trichlorophenol and dichloroethane taken as major raw materials directly react with propylamine after the 2, 4, 6- trichlorophenol and the dichloroethane are subjected to pressure condensation, are subjected to acyl chlorination through trichloromethyl carbonate, and react with imidazole to produce the prochloraz in the presence of triethylamine. Compared with the prior producing process, the method cancels intermediate washing, greatly reduces factory effluent, and improves product yield.
Owner:江苏乐斯化学有限公司 +2
Anti-tearing flame-retardant cable material and method for manufacturing same
InactiveCN105153529AHigh grafting rateImprove adsorption capacityPlastic/resin/waxes insulatorsPhosphorous acidGas phase
The invention discloses an anti-tearing flame-retardant cable material. The anti-tearing flame-retardant cable material comprises, by weight, 70-80 parts of ethylene-vinyl acetate copolymers, 20-30 parts of high-density polyethylene, 30-50 parts of gas-phase white carbon black, 10-15 parts of nano crystalline cellulose, 3-4 parts of gamma-(2, 3-trimethoxysilyl) propyl methacrylate, 40-50 parts of magnesium hydroxide, 1-3 parts of melamine cyanurate, 3.5-4.5 parts of gas-phase silicon dioxide, 15-30 parts of dioctyl terephthalate, 15-30 parts of epoxy soybean oil, 0.4-1 part of dicumyl peroxide, 0.5-1.5 parts of zinc oxide, 0.5-1.5 parts of diethylin propylamine, 5-10 parts of maleic anhydride grafting compatilizer, 2-4 parts of Ca / Zn compound stabilizers, 1-2 parts of magnesium stearate, 0.1-0.3 part of antioxidants 1010, 0.1-0.2 part of trioctylphosphine phosphorous acid ester and 1-3 parts of polyethylene wax. The invention further discloses a method for manufacturing the anti-tearing flame-retardant cable material.
Owner:无为县茂林电缆材料有限公司
Synthetic method for preparing roxatidine acetate hydrochloride with high purity
InactiveCN102993121AHigh purityThe synthesis process is simple and safeOrganic chemistryPotassium acetatePhenol
The invention discloses a synthetic method for preparing roxatidine acetate hydrochloride with high purity. According to the invention, a starting material hydroxybenzaldehyde is subjected to condensation with piperidine to prepare 3-(1-piperidine methyl) phenol; an intermediate and 3-chloro amine hydrochloride are subjected to a backflow etherification reaction in a DMF at high temperature to obtain 3-(3-(1-piperidyl methyl) phenoxy) propylamine; the 3-(3-(1-piperidyl methyl) phenoxy) propylamine, chloroacetyl chloride and potassium acetate are subjected to a heating reflux reaction in a tetrahydrofuran solvent; and a HCl / THF solution is introduced to prepare a final product roxatidine acetate hydrochloride, with a total yield of 68%. The synthesis process has advantages of simpleness, low cost and high yield, can provide purity of the target product, and is in favor of industrial mass production of the product.
Owner:哈药集团人民同泰医药股份有限公司
Spray coating solution, perovskite layer, preparation method of perovskite layer and perovskite cell
ActiveCN108057590AGood film formingImprove continuityFinal product manufactureSolid-state devicesAlcoholSpray coating
The invention relates to the photovoltaic field, in particular to a spray coating solution used for preparing a perovskite layer. The spray coating solution comprises a mixed solvent and a perovskitematerial. The mixed solvent is formed by mixing acetonitrile and an amine solution. The solute of the amine solution is at least one of methylamine, propylamine and butyl amine. The solvent of the amine solution is at least one of methyl alcohol, ethyl alcohol and tetrahydrofuran. According to the spray coating solution, the acetonitrile and the amine solution are used as the mixed solvent to dissolve the perovskite material, after spray coating and annealing, the obtained perovskite layer is good in film-forming property and continuity, the film is provided with few holes and is smooth, uniform and good in quality, and therefore the property improvement of a perovskite cell is facilitated. In addition, by the adoption of the spray coating solution, the annealing temperature is low, the utilization rate of the materials is high, and therefore the production cost of the perovskite layer is lowered. The invention further discloses a preparation method of the perovskite layer, the perovskite layer and the perovskite cell.
Owner:KUNSHAN GCL OPTOELECTRONIC MATERIAL CO LTD
Double-component epoxy adhesive for bonding ceramics, preparation method and using method thereof
InactiveCN102220101AReduce internal stressHigh bonding strengthNon-macromolecular adhesive additivesCarboxyl rubber adhesivesFiberCarbon nanotube
The invention relates to a double-component epoxy adhesive for bonding ceramics, a preparation method and using method thereof, belonging to the adhesive field, and aiming at solving the technical problem that the interfacial stress is overhigh owning to great difference of linear expansion coefficients when the existing epoxy adhesive is used for bonding the ceramics. The component A of the double-component epoxy adhesive is prepared by E-44 epoxy resin, E-51 epoxy resin, carboxy terminal butadiene-acrylonitrile, ground quartz, carbon fiber, carbon nano tube, SiC crystal whisker and ultraviolet absorber UV-531, the component B of the double-component epoxy adhesive is prepared by 3-diethylin propylamine, silane coupling agent KH-550, accelerating agent DMP-30 and ground quartz, and the double-component epoxy adhesive is prepared by a mixing method. When the adhesive is used, the adhesive is coated on a surface to be adhered for superimposition and solidification; and the shearing strength of the adhesive can reach more than 60MPa when the adhesive is used for bonding SiC ceramic; the bonding interface is good, an obvious mechanical embedding function is realized between an adhesive layer and a parent metal, and the defects such as cracks, air holes and the like do not exist in the adhesive layer.
Owner:HARBIN INST OF TECH
Preparation method of cartap hydrochloride intermediate, i.e., 2-N, N-dimethyl-1, 3-dithio-cyano propane
The invention relates to a preparation method for cartap hydrochloride intermediate, i.e., 2-N, N-dimethyl-1, 3-dithio-cyano propane, which takes 1-N, N-dimethyl-2, 3- propylamine dihalide, thiocyanate as the raw material, obtains the mixture of 2-N, N-dimethyl-1, 3-dithio-cyano propane and 3-N, N-dimethyl-1, 2-dithio-cyano propane by reaction with the existence of a solvent, and obtains 2-N, N-dimethyl-1, 3-dithio-cyano propane with high content by separation; simultaneously, 3-N, N-dimethyl-1, 2-dithio-cyano propane isomer participates the reaction circularly, thus having high yield, good product quality, small amount of three wastes, and better industrial application prospect.
Owner:ZHEJIANG BOSHIDA CROP TECH CO LTD
Method for synthesizing SAPO-41 (Phosphoric Acid Silicon-Aluminum-41) molecular sieve by adopting novel template agent
ActiveCN103011196ALow priceReduce dosageMolecular-sieve and base-exchange phosphatesMolecular-sieve silicoaluminophosphatesMolecular sieveSynthesis methods
The invention discloses a method for synthesizing SAPO-41 (Silico-Alumino-Phosphate-41) molecular sieve by adopting a novel template agent, relates to a synthesis method of the silico-alumino-phosphate molecular sieve, in particular relates to a synthesis method of the silico-alumino-phosphate molecular sieve SAPO-41, and solves the problems that the method for synthesizing the SAPO-41 molecular sieve by using a conventional DPA (Di-n-Propylamine) as the template agent is high in preparation cost, has mixed crystal and is not beneficial for the realization of large-scale industrial production. The method comprises the following steps: firstly, preparing 85 percent by mass of phosphoric acid, pseudo-boehmite, di-n-butylamine, silica sol and distilled water into initial gel; and secondly, crystallizing, cooling to the room temperature, centrifuging, washing, drying, roasting and naturally cooling the initial gel to the room temperature so as to obtain the SAPO-41 molecular sieve. The method has the advantages that firstly, the product is in pure phase; secondly, the synthesis cost of the molecular sieve is greatly reduced; and thirdly, the large-scale industrial production is realized. The method is mainly used for synthesizing the SAPO-41 molecular sieve.
Owner:HEILONGJIANG UNIV
Method for preparing thermoplastic polyurethane (TPU)/ kieselguhr composite material
The invention relates to a method for preparing a thermoplastic polyurethane (TPU) / kieselguhr composite material. The method comprises the following steps: (1) mixing kieselguhr, cyclohexane, propylamine, and silane coupling agent sequentially, stirring, evaporating, performing vacuum drying, and collecting kieselguhr modified by the silane coupling agent; and at room temperature, adding a TPU solvent into the kieselguhr modified by the silane coupling agent, performing ultrasonic dispersion, adding TPU again, stirring, and after the TPU is completely dissolved, performing ultrasonic stirring at the speed of 500 to 800r / min for 1 to 2 hours, and evaporating the solvent at the temperature of between 80 and 110 DEG C to obtain the TPU / kieselguhr composite material. In the method, the energy consumption is low, the period is short, and the composite material is convenient to process and form, and is suitable for large-scale production. The mechanical property and the heat resistance of the prepared TPU / kieselguhr composite material are improved greatly; and the tensile strength of the TPU is increased by 62.24 percent.
Owner:DONGHUA UNIV
Preparation method of ethyl acetoacetate
ActiveCN103450018AImprove stabilityReduce consumptionPreparation from ketenes/polyketenesAcetic acidNitrate
The invention provides a preparation method of ethyl acetoacetate. The preparation method sequentially comprises the following steps of: (1) fully dissolving ethanol and a catalyst, then adding the mixture into an esterification reaction kettle, heating up, and dropwise adding ketene dimer; (2) after completing dropwise addition, insulating, and cooling to produce crude ethyl acetoacetate; (3) rectifying the crude product to obtain the finished ethyl acetoacetate. The preparation method is characterized in that the catalyst in the step (1) is an amine type ionic liquid catalyst which is selected from one or more of n-butylamine nitrate, n-butylamine acetate, ethylamine nitrate, ethylamine acetate, propylamine nitrate and propylamine acetate. According to the preparation method of ethyl acetoacetate, the amine type ionic liquid catalyst is researched and is good in stability, the stability of ethyl acetoacetate is enhanced under the action of the catalyst, the rectification yield of a product can be improved, the technological operations are simple, the raw material consumption is reduced, and the catalyst has obvious advantages and positive effects.
Owner:NANTONG ACETIC ACID CHEM
Novel magneticfluid sealant
ActiveCN104008845AFast deliveryGuaranteed normal operationMagnetic liquidsWater turbineMicroparticle
Owner:冯智勇
Tulathromycin intermediate, preparation method of tulathromycin intermediate and preparation method of tulathromycin
InactiveCN103772459AAvoid residueSimple and safe operationSugar derivativesSugar derivatives preparationBeckmann rearrangementHydrolysis
The invention provides a tulathromycin intermediate, a preparation method of the tulathromycin intermediate and a preparation method of tulathromycin. According to the preparation method, Erythromycin A (E) oxime used as a starting material is subjected to acetyl protection, Albright-Goldman oxidation, Corey-Chaykovsky epoxidation, deprotection, Beckmann rearrangement, reduction and hydrolysis, and n-propylamine ring opening to synthesize tulathromycin. The preparation method has mild conditions, has the advantages of convenient operation, high yield and low cost and is beneficial to industrial production, and the raw materials are easily available.
Owner:QINGDAO VLAND BIOTECH INC
Preparation method of montelukast sodium
The invention discloses a preparation method of a montelukast sodium, and the preparation method comprises the following steps: step A, transforming a montelukast free acid into a montelukast dicyclohexylamine salt; step B, transforming the montelukast dicyclohexylamine salt into a montelukast di-n-propylamine salt; step C, transforming the montelukast di-n-propylamine salt into a montelukast sodium salt. The preparation method of the montelukast sodium salt disclosed by the invention has the advantages of simplicity in operation, high yield, high product purity and the like.
Owner:ZHEJIANG CHARIOTEER PHARMA
Chemical detergent for clearing hard scales from air pre-heater and preparation method thereof
InactiveCN107674778AEasy to cleanNo corrosionInorganic/elemental detergent compounding agentsCationic surface-active compoundsPentaerythritolPhosphate
The invention discloses a chemical detergent for clearing hard scales from an air pre-heater, and belongs to the technical field of detergents. The chemical detergent is prepared from the following ingredients in parts by weight: 22-25.5 parts of 3-methoxy propylamine, 8.3-9.7 parts of pentaerythritol phosphate, 11.2-12.9 parts of N,N-dimethylacetamide, 1.4-2.6 parts of sodium hydroxide, 18.8-20 parts of trisodium phosphate, 7.3-8.8 parts of corrosion inhibitor, 5.6-6.4 parts of stripper, 3.2-4.1 parts of penetrant, 2.5-3.3 parts of surfactant, 8.7-9.6 parts of scale inhibitor, 3.5-4.4 parts of dispersant and 45-58 parts of water. The detergent provided by the invention has the advantages of good comprehensive performance, remarkable cleaning effect and stable performance, and can form a protective layer on the surface of the air pre-heater to play roles in inhibiting scales and preventing rust, and thus, the service life of the air pre-heater is prolonged.
Owner:NANYANG INST OF TECH
Polyurethane foam with heat conductivity coefficient enhanced by hollow glass beads
InactiveCN106244084AHigh oxygen indexImprove flame retardant performancePolyureas/polyurethane adhesivesDiethyl phosphateGlycerol
The invention discloses polyurethane foam with heat conductivity coefficient enhanced by hollow glass beads. The polyurethane foam is prepared from, by weight, 150-160 parts of diphenyl-methane-diisocyanate, 100-105 parts of propoxylated glycerin, 100-110 parts of castor oil, 5-6 parts of glycerol, 40-43 parts of diethyl phosphate, a proper amount of 1 mol / L sodium hydroxide solution, 13-15 parts of diatomite, 5-6 parts of distilled water, 2-3 parts of triethanolamine, 3-4 parts of dibutyltin dilaurate, 4-5 parts of polyacrylamide, 3-4 parts of ethoxylated lauryl alcohol sulfate, 6-7 parts of hollow glass beads, 20-23 parts of cyclohexane, 0.2-0.22 part of n-propylamine, 0.6-0.7 part of silane coupling agent KH550 and a proper amount of deionized water. The prepared foam can be foamed on the spot, has the characteristics of being uniform in foaming, high in cell density and low in heat conductivity coefficient, is used for sealing of a switch cabinet, and is high in binding strength, good in sealing and excellent in heat preservation performance.
Owner:HEFEI E CHON METAL PLATE TECH CO LTD
Preparation of ropinirole hydrochloride
InactiveCN101481347ARaw materials are easy to getLow costNervous disorderOrganic chemistryBenzaldehydeKetone
The invention relates to a method for preparing ropinirole hydrochloride, comprising the followings in turn: (1) beta-phenylethyl alcohol reacts with paraformaldehyde to produce isochroman; (2) the product obtained in step (1) reacts with bromide to produce 2-bromoethyl benzaldehyde; (3) the product obtained in step (2) reacts with nitromethane to produce 2-bromoethyl nitrostyrolene; (4) the product obtained in step (3) reacts with acetyl chloride to produce 4-bromoethyl-3-chloride-1, 3-dihydro-2H-indole-2-ketone; (5) 4-bromoethyl-1, 3- dihydro-2H-indole-2-ketone is obtained after catalytic hydrogenation of the product obtained in step (4); (6) 4-ethoxyl-1, 3-dihydro-2H-indole-2-ketone is obtained after acetylation and hydrolysis of the product obtained in step (5); (7) the product obtained in step (6) reacts with toluene sulfonic acid to produce toluene sulfonic acid-2-(2-oxygen-1, 3-dihydro-4-indole) ethyl ester; (8) the product obtained in step (7) and di-n-propylamine undergo reflux reaction in water and pH value is regulated by hydrochloric acid to 1-2 to obtain the ropinirole hydrochloride. In the method, the raw materials are easily acquired; the target products enjoy high selectivity and yield, thus being suitable for industrial production.
Owner:太仓浦源医药原料有限公司
Synthesis process of roxatidine acetate hydrochloride
The present invention discloses synthesis process of roxatidine acetate hydrochloride. The synthesis process includes the following steps: the reducing aminolysis reaction of m-hydroxy benzaldehyde as the initial material and piperidine to obtain 3-piperidino methyl phenol, the condensation of 3-piperidino methyl phenol and 3-halo propylamine to obtain 3-piperidino methyl-phenoxy propylamine, the amidation of 3-piperidino methyl-phenoxy propylamine and acetyloxy acetyl chloride to obtain 2-acetyloxy-N-[3-[3-(1- piperidino methyl phenyl) oxy] propyl] acetamide, and introducing dry HCl gas into anhydrous alcohol-acetone solution of 2-acetyloxy-N-[3-[3-(1- piperidino methyl phenyl) oxy] propyl] acetamide to obtain the ultimate compound 2-acetyloxy-N-[3-[3-(1- piperidino methyl phenyl) oxy] propyl] acetamide hydrochloride. The process is simple, high in target compound and favorable to industrial production.
Owner:LANZHOU INST OF CHEM PHYSICS CHINESE ACAD OF SCI
Preparation method of triazole derivative
The invention discloses a preparation method of a triazole derivative N-((5-(4-bromophenyl)-2H-1,2,4-triazole-3-yl)methyl)-N-propyl-1-propylamine. According to the preparation method, 3-(4-bromophenyl) ethyl acrylate is taken as the starting raw material, and the starting raw material is enabled to go through reduction, acylation, imidization, ring closing, Boc removal and alkylation reaction, and then the target product 7 can be obtained; the product is taken as a template micromolecule to synthesize diverse compound libraries.
Owner:湖南华腾制药有限公司
Color change indicating device and transparent ink
ActiveCN105548176APH effectAvoid interferenceMaterial analysis by observing effect on chemical indicatorInksPolyvinyl alcoholAmmonium hydroxide
The invention relates to a color change indicating device and transparent ink. The color change indicating device comprises a substrate layer and an indicating layer formed on the surface of the substrate layer. The indicating layer comprises an indicating portion which is formed by printing of indicating ink. The color change indicating device further comprises a protective layer covering the surface of the indicating portion. The protective layer is formed by printing of the transparent ink. The transparent ink is prepared from volatile alkali, a binding agent, a solvent and acid materials. The indicating ink is prepared from volatile alkali, a binding agent, a solvent, acid materials and a pH indicating agent. The volatile alkali is selected from at least one of ammonia water, ammonium hydroxide, propylamine, n-butylamine, normal hexyl amine and n-octylamine, the binding agent is selected from at least one of polyvinyl butyral, nitrocotton, polyvinyl alcohol, hydroxyethyl cellulose and hydroxy propyl cellulose. The pH value of the transparent ink is the same as that of the indicating ink. The color change indicating device can effectively prevent deviation of the pH value of the indicating portion.
Owner:SHENZHEN NINE STARS PRINTING & PACKAGING GRP
Industrial preparation method of pramipexole dihydrochloride
InactiveCN103626718AReduce usageRaw materials are easy to getOrganic chemistryDrugs synthesisPramipexole Dihydrochloride
The invention relates to an industrial preparation method of pramipexole dihydrochloride, belonging to the technical field of drug synthesis. The industrial preparation method is characterized by using (S)-(-)-2,6-diamino-4,5,6,7-tetrahydrobenzothiazole as a raw material to react with n-propanal to generate Schiff base, then carrying out NaBH4 reduction and recrystallization to obtain (S)-(-)-2-amino-6-propylamine-4,5,6,7-tetrahydrobenzothiazole, and finally preparing pramipexole dihydrochloride monohydrate through salifying and recrystallization. The industrial preparation method of pramipexole dihydrochloride avoids using toxic reagents and has the advantages of accessible raw materials, simplicity in operation and high reaction safety.
Owner:SHANDONG XINHUA PHARMA CO LTD
Antirust coating for automobile chassis
InactiveCN108300064AGood adhesionGood embroidery performanceAnti-corrosive paintsNano al2o3Chlorinated paraffins
The invention discloses an antirust coating for an automobile chassis, and relates to the technical field of coatings. The antirust coating is prepared from an acrylic emulsion, xanthan gum, a defoaming agent, a dispersant, a film forming additive, barium sulfate, modified zinc phosphate, a surfactant, isotridecyloxy propylamine, nano-alumina, talcum, tributyl phosphate, oxidized starch, sepiolitepowder and chlorinated paraffin. The antirust coating for the automobile chassis uses the acrylic emulsion as a basic film forming substance, contains general coating components, and also contains the modified zinc phosphate, and the modified zinc phosphate is chemically reacted with iron rusts to convert harmful iron rusts into harmless or protective substances, so the coating containing the modified zinc phosphate has a fast effect on the iron rusts, can be applied together with rusts, and can wet and infiltrate a loose and porous corrosion layer to convert the iron rusts into inert and non-corrosive black substances.
Owner:安徽喜宝高分子材料有限公司
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