Method for producing bactericide prochloraz

Abstract

The invention relates to a method for industrially producing disinfecting agent prochloraz, which is characterized by comprising the following steps: 2, 4, 6-trichlorophenol and dichloroethane taken as major raw materials directly react with propylamine after the 2, 4, 6- trichlorophenol and the dichloroethane are subjected to pressure condensation, are subjected to acyl chlorination through trichloromethyl carbonate, and react with imidazole to produce the prochloraz in the presence of triethylamine. Compared with the prior producing process, the method cancels intermediate washing, greatly reduces factory effluent, and improves product yield.

Description

Technical field:

[0001] The invention relates to a production method of prochloraz, a pesticide fungicide, which is suitable for the production of prochloraz original drug by using 2,4,6-trichlorophenol and dichloroethane as main raw materials, and belongs to the field of pesticide chemical industry. Background technique:

[0002] Prochloraz (Prochloraz), the chemical name is N-propyl-N-(2,4,6-trichlorophenoxyethyl)-1H-imidazole-1-carboxamide, is a British Boots Co., Ltd. in Synthesized in 1974 and introduced to the market in 1977, it is an imidazole-based high-density broad-spectrum fungicide. It works by inhibiting the biosynthesis of sterols, and has a good control effect on various pathogens of rice, fruits, and cereals.

[0003] There are many preparation methods of prochloraz, and the process route is complicated. In 1976, US Patent No. 3 991 071 described a preparation method using 2,4,6-trichlorophenol and dibromoethane as main raw materials. Dibromoethane is known...