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Method for obtaining anatomical structural atlas for target mouse based on XCT image non-rigid registration

A technology of anatomical structure and acquisition method, applied in the field of non-stiffness image registration and finite element calibration of target mouse tissue anatomy, can solve the problems of cumbersome experimental process, complex imaging system and high cost

Inactive Publication Date: 2015-08-26
TIANJIN UNIV
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Problems solved by technology

This method can accurately obtain the anatomical structure information of mice, which provides important reference significance for related research, but the imaging system used in this method is complicated, the experimental process is cumbersome, and the cost is high, which is also unfavorable for conventional mouse FMT experiments. use

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  • Method for obtaining anatomical structural atlas for target mouse based on XCT image non-rigid registration
  • Method for obtaining anatomical structural atlas for target mouse based on XCT image non-rigid registration
  • Method for obtaining anatomical structural atlas for target mouse based on XCT image non-rigid registration

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Embodiment Construction

[0069] The technical solutions of the present invention will be described in further detail below in conjunction with the accompanying drawings and specific embodiments, and the described specific embodiments are only to illustrate the present invention, and are not intended to limit the present invention.

[0070] figure 1 The basic steps of the target mouse anatomical structure atlas acquisition method based on XCT image non-stiffness registration of the present invention are shown as follows:

[0071] First, set the Digimouse structure as the reference mouse anatomical structure atlas, and set the XCT image corresponding to the Digimouse as the reference image;

[0072] Secondly, perform XCT imaging on the target mouse to obtain the target image and perform preprocessing;

[0073] Then, a registration mapping matrix from the reference image to the target image is constructed using non-stiffness image registration technology;

[0074] Finally, the registration mapping matr...

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Abstract

The invention discloses a method for obtaining anatomical structural atlas for a target mouse based on XCT image non-rigid registration. The method includes basic steps of setting Digimouse model as referential mouse anatomical structural atlas, setting XCT images corresponding to Digimouse as referential images, obtaining and pretreating XCT images of the target mouse, building referential images to registration mapping matrix of the target images by non-rigid registration technology, acting registration mapping matrix onto the referential mouse anatomical structural atlas to build a target mouse anatomical structural atlas and mark tissue and organs of the target mouse. The registration method is high in precision, and tissue and organs of a mouse can be marked on a mouse XCT image in a simple and easy way through image registration method. The method is also applicable to other medical science application fields, such as brain structure research, i.e. the anatomical structure of a target brain can be obtained by standard brain anatomical images.

Description

technical field [0001] The invention belongs to the technical field of image processing, and in particular relates to non-stiffness image registration and finite element calibration of target mouse tissue anatomy. Background technique [0002] The uniform optical structure background commonly used in the current Fluorescence Molecular Tomography (FMT) method will introduce significant errors in the modeling of photon transport. Significance. The establishment of the optical structure is closely related to the acquisition of anatomical structure information: on the one hand, it is the physical geometric information that endows the characteristics of the relevant optical parameters of each region in the anatomical structure; on the other hand, it is the prerequisite for the in vivo acquisition of the optical parameters of each region [1,2] . [0003] Common anatomical imaging modalities have certain limitations when used for optical structure acquisition. High-field small a...

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Application Information

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IPC IPC(8): G06T3/00G06T7/00
CPCG06T7/12G06T2207/10081G06T3/147
Inventor 高峰万文博赵会娟
Owner TIANJIN UNIV
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