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Multi-foci sonications for hyperthermia treatments using magnetic resonance-guided focussed ultrasound.

A sonication, high temperature technology, applied in the field of high temperature treatment, can solve problems such as mechanical tissue damage

Inactive Publication Date: 2015-09-02
博放医疗有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In addition, a single high-intensity focal spot may also be more prone to inducing unwanted mechanical tissue damage

Method used

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  • Multi-foci sonications for hyperthermia treatments using magnetic resonance-guided focussed ultrasound.
  • Multi-foci sonications for hyperthermia treatments using magnetic resonance-guided focussed ultrasound.
  • Multi-foci sonications for hyperthermia treatments using magnetic resonance-guided focussed ultrasound.

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Experimental program
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Embodiment Construction

[0037]The optimum temperature for most mildly high temperature applications is in the 40-45°C range. Temperatures below 40°C typically have limited effect and temperatures above 45°C can shut off tissue perfusion. In contrast, in ablation techniques, the temperature is raised to a level capable of inducing necrosis, typically greater than 55°C, and the tissue is then allowed to cool. Excessive heating of the target tissue to be ablated is not detrimental. The present mild hyperthermia technique maintains the temperature in the target area at a desired level, eg, between 40.5°C and 41.0°C for long durations typically 3-45 minutes or more. During this time, power, frequency and trajectory are adjusted to obtain optimal heating uniformity in the target volume for, eg, uniform tissue sensitization or drug delivery.

[0038] The effect of HIFU on tissue is highly dependent on the acoustic intensity of the focal region, where different mechanisms of HIFU energy propagation play a ...

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Abstract

A mild hyperthermia treatment apparatus (10) includes an imager (12),which generates a planning image (34) and temperature maps (36) of a target region. An array of ultrasonic transducer drivers (52) individually drives ultrasonic transducers of a phased array of ultrasonic transducers (50). One or more processors or units receive a target temperature profile, and calculate power, frequency,and relative phase for the transducer drivers to drive the phased array of ultrasonic transducers to generate a multi-foci sonication pattern configured to heat the target region with the target temperature profile while limiting peak acoustic pressures. During treatment, the imager generates a series of temperature maps which the one or more processors or units compare with the target temperature profile and, based on the comparison, adjust the power, frequency and relative phase with which the transducer drivers drive the ultrasonic transducers.

Description

technical field [0001] The present application relates to apparatus and methods for high temperature treatment using multi-focal sonication. Background technique [0002] Hyperthermia (HT) is a therapeutic technique in which tissue is heated to a temperature above body temperature and below ablation temperature (eg, 38-45°C). These mild hyperthermic treatments may result in physiological (eg, perfusion) and cellular (eg, gene expression) changes that improve efficacy when used in conjunction with chemotherapy or radiation therapy. Mild hyperthermia induces numerous changes that provide clinical benefits that make it synergistic with many chemotherapeutic agents and radiation therapy. In addition to physiological and cellular changes, high temperatures can be used with temperature-responsive as well as non-responsive drug delivery systems to induce toxicity and improve overall efficacy. One solution to reduce toxicity involves targeting tumors using temperature-sensitive li...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61N7/02A61B19/00A61B17/00
CPCA61N2007/027A61B2019/5236A61B2019/501A61B2017/00084A61N7/02A61B2034/101A61B2090/374A61B5/015A61B5/055A61B5/742A61B5/4839A61B5/7278A61B5/7475A61B2576/00A61M37/0092A61M2037/0007A61N2007/0078
Inventor A·I·M·帕尔塔宁M·O·蒂兰德M·德雷埃尔M·科勒
Owner 博放医疗有限公司
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