A kind of synthetic method of 25-hydroxy-7-dehydrocholesterol

A technique for the synthesis of dehydrocholesterol, which is applied in the fields of steroids and organic chemistry, can solve the problems of cumbersome steps, achieve high reaction efficiency, good reaction selectivity, and avoid recovery operations
CN104910231BActive Publication Date: 2016-08-24ZHEJIANG UNIV OF TECH +2
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
ZHEJIANG UNIV OF TECH
Publication Date
2016-08-24

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Abstract

The present invention relates to a 25-hydroxy-7-dehydrocholesterol synthetic method, a 25-hydroxy-7-keto-cholesterol derivative is used as a raw material for mechanical milling reaction in a ball mill pot under the effect of sulfonyl hydrazide and a base in the absence of an organic solvent, and then hydrolysis reaction is performed to obtain 25-hydroxy-7-dehydrocholesterol synthetic method. According to the method, in the absence of a solvent, mechanical milling reaction is performed, no dust is spilled over in the grinding process, reaction controllability is good, reaction efficiency is high, the solvent recovery operation in the post-processing process can be avoided, operation is simplified, environmental pollution is reduced, the reaction selectivity is good, yield is high, operation is simple, cost is low, post-treatment is simple, three-waste is less, product is easy to separate, purity is high, the yield is up to 89%, the melting process is short, and the product purity is high.
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Description

technical field

[0001] The invention relates to a method for synthesizing 25-hydroxyl-7-dehydrocholesterol. Background technique

[0002] 25-hydroxy-7-dehydrocholesterol aka 25-hydroxyvitamin D 3 Originally, 25-hydroxyvitamin D can be synthesized by ultraviolet light irradiation 3 , 25-Hydroxyvitamin D 3 Also known as calcifediol, vitamin D 3 The active metabolites of the liver in the body have stronger physiological activities and can be used as feed additives, which have been widely used in animal breeding.

[0003] 25-Hydroxyvitamin D 3 The market is very good, and it has been widely used in the breeding industry in Europe, so the market potential of the key intermediate 25-hydroxy-7-dehydrocholesterol is very large. Before the present invention, 25-hydroxy-7-dehydrocholesterol was generally prepared from 25-hydroxycholesterol derivatives through bromination-debromination reaction. The reaction formula is as follows (Journal of Organic Chemistry, 2005, 70(21), 8513-...

Claims

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