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Preparation method and application of Jieshitong tablets

A technology of tablet and stone, which is applied in the field of preparation of tablet tablets, can solve the problems of large dosage for patients, easy escape of volatile components of drugs, and destruction of chemically unstable components, and achieve the effect of reducing dosage

Inactive Publication Date: 2015-09-23
广东恒诚制药股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the prior art, there is no report on the use of supercritical and microwave technology in the extraction and preparation of Jieshitong Tablets. However, the method of powdering and decocting in water is rough and backward, and some components with high boiling point and low volatility cannot be extracted. All extracted, and under high temperature for a long time, the volatile components of the drug are easy to escape, and some pyrolyzable substances or chemically unstable components are also easily destroyed. The efficacy of this product leads to excessive dosage for patients, which is inconvenient to take, which seriously affects the clinical application of this product.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Take golden grass, sea gold sand grass, and plantain and add them to CO 2 In the supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer in the total extraction solvent is 3%. The isothermal positive pressure method is used for extraction. The first extraction pressure is 10MPa, the extraction time is 30min, and the second extraction pressure is 20Mpa. The extraction time is 45min, the third extraction pressure is 40Mpa, the extraction time is 45min, the temperature is 45°C, CO 2 The flow rate is 3m1 / g crude drug·min to obtain supercritical extract, which is used for later use; take chicken bone grass and corn silk, grind them, add 2L of 70% ethanol, and put them into a microwave extraction device for microwave extraction. The extraction power is 500W, and the extraction is performed twice. For 8 minutes each time, combine the extracts, concentrate, add to D101 macroporous adsorption resin column, elute with 50% ethanol, coll...

Embodiment 2

[0017] Take golden grass, sea gold sand grass, and plantain and add them to CO 2 In the supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer in the total extraction solvent is 5%. The isothermal positive pressure method is used for extraction. The first extraction pressure is 20MPa, the extraction time is 60min, and the second extraction pressure is 30Mpa. The extraction time is 75min, the third extraction pressure is 50Mpa, the extraction time is 75min, the temperature is 55°C, CO 2 The flow rate is 5m1 / g crude drug min to obtain the supercritical extract, which is used for later use; take chicken bone grass and corn silk, grind them, add 2L of 70% ethanol, and put them into a microwave extraction device for microwave extraction. The extraction power is 500W, and the extraction is performed twice. For 12 minutes each time, combine the extracts, concentrate, add to D101 macroporous adsorption resin column, elute with 50% ethanol,...

Embodiment 3

[0019] Take golden grass, sea gold sand grass, and plantain and add them to CO 2 In the supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer in the total extraction solvent is 4%. The isothermal positive pressure method is used for extraction. The first extraction pressure is 15MPa, the extraction time is 45min, and the second extraction pressure is 25Mpa. The extraction time is 60min, the third extraction pressure is 45Mpa, the extraction time is 60min, the temperature is 50°C, CO 2 The flow rate is 4m1 / g crude drug min to obtain the supercritical extract, which is used for later use; take chicken bone grass and corn silk, grind them, add 2L of 70% ethanol, and put them into a microwave extraction device for microwave extraction. The extraction power is 500W, and the extraction is performed twice. For 10 minutes each time, combine the extracts, concentrate, add to D101 macroporous adsorption resin column, elute with 50% ethanol,...

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PUM

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Abstract

The invention discloses a preparation method of Jieshitong tablets. The Jieshitong tablets are prepared from raw materials as follows: 456 g of longhairy antenoron herb, 228 g of Indian buead, 228 g of abrus herb, 228 g of pyrrosia leaves, 165 g of Lygodium japonicum, 302 g of corn stigma, 228 g of lalang grass rhizomes and 165 g of plantain herb. The Jieshitong tablets are prepared through supercritical fluid extraction, microwave extraction and micro-pore filter filtration, and the effective content is greatly increased. The invention further provides an application of the Jieshitong tablets in preparation of medicines for inhibiting RAG (mouse renal adenocarcinoma cell) proliferation.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicines, in particular to a preparation method and application of Jieshitong tablets. Background technique [0002] Jieshitong Tablets are recorded in the "State Food and Drug Administration" YBZ10272008, consisting of 456g of Desmodium spp., 228g of Poria cocos, 228g of Jigucao, 228g of Shiwei, 165g of sea ginseng, 302g of corn silk, 228g of Imperata rhizome, and 165g of plantain It is made as a raw material medicine. Take 96g of the above eight flavors and pulverize them into fine powder. The remaining Poria cocos and the other seven flavors such as corn silk are decocted twice for 3 hours each time. The decoctions are combined and filtered. 1.19-1.20 (90°C) clear ointment, add poria cocos fine powder, mix well, dry, crush into fine powder, sieve, add appropriate amount of auxiliary materials, make granules, mix well, press into 1000 tablets, coat with sugar, and get ready. Can ...

Claims

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Application Information

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IPC IPC(8): A61K36/899A61P35/00
Inventor 陈雨汤小燕张志涛符正南李智洋黎景如
Owner 广东恒诚制药股份有限公司
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