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Leukocyte filtering membrane, manufacturing method and applications thereof

A leukocyte and filtration membrane technology, applied in the field of new leukocyte-removing filtration membranes, can solve the problems of low platelet passing rate, high platelet adhesion, and little platelet adsorption.

Active Publication Date: 2015-09-23
上海世龙科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the disadvantage of this material is that the pass rate of platelets is relatively small (the current requirement must be greater than 90%)
Due to the high adhesion of platelets, none of the existing filter membrane materials for removing leukocytes can meet the requirement that the pass rate of platelets exceed 90%.
[0006] The Japanese patent JP4 936 998 (Takao et al.) of Asahi Corporation of Japan reported that when the surface of the fiber contains both non-ionic hydrophilic groups and nitrogen-containing functional groups, and the nitrogen atom content is 0.2-4.0%, the fiber has a great effect on leukocytes. Good adsorption capacity, but rarely adsorbs platelets

Method used

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  • Leukocyte filtering membrane, manufacturing method and applications thereof
  • Leukocyte filtering membrane, manufacturing method and applications thereof
  • Leukocyte filtering membrane, manufacturing method and applications thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0080] 1. Preparation of graft mixture

[0081] Dissolve 65 grams of acrylic acid and 0.065 grams of copper sulfate in 585 milliliters of deionized water to form a mixed solution.

[0082] 2. Irradiation grafting

[0083] A piece of melt-blown PBT nonwoven fabric with an area of ​​0.2 square meters (gram weight 170±10 g / square meter, pore size 45±3 microns, purchased from Wuhu Aidi Purification Equipment Co., Ltd.) was immersed in the above-mentioned graft mixture in the liquid. At room temperature using gamma rays ( 60 Co, irradiation dose is 5kGy) radiation grafting for 46 hours. The nonwoven fabric was taken out, rinsed with water, dried in an oven at 40°C, and the acrylic acid grafting rate was measured by the above-mentioned method, and the result was 10%.

[0084] 3. Performance test

[0085] The blood leukocyte residual rate, leukocyte removal rate and hemolysis rate of the product were measured by the above method. As a result, the leukocyte removal rate was 98.8%, ...

Embodiment 2

[0087] 1. Preparation of graft mixture

[0088] Dissolve 17 grams of vinylpyrrolidone and 0.065 grams of copper sulfate in 633 milliliters of deionized water to form a mixed solution.

[0089] 2. Irradiation grafting

[0090] A piece of melt-blown PBT nonwoven fabric with an area of ​​about 0.2 square meters (gram weight 170±10 g / square meter, pore size 45±3 microns, purchased from Wuhu Aidi Purification Equipment Co., Ltd.) was immersed in the above graft in the mixture. At room temperature using gamma rays ( 60 Co, irradiation dose is about 10kGy) radiation grafting for about 17 hours. The nonwoven fabric was taken out, rinsed with water, dried in an oven at 40°C, and the vinylpyrrolidone grafting rate was measured by the above-mentioned method, and the result was 12%.

[0091] 3. Performance test

[0092] Measure the blood leukocyte residual rate, leukocyte removal rate and hemolysis rate of this product by the above method, the result leukocyte removal rate is 98.5%, ...

Embodiment 3

[0094] 1. Preparation of graft mixture

[0095] 30 grams of acrylic acid, 32 grams of methacrylic acid, and 0.065 grams of copper sulfate were dissolved in 585 milliliters of deionized water to form a mixed solution.

[0096] 2. Irradiation grafting

[0097] A piece of melt-blown PBT nonwoven fabric with an area of ​​0.2 square meters (gram weight 170±10 g / square meter, pore size 45±3 microns, purchased from Wuhu Aidi Purification Equipment Co., Ltd.) was immersed in the above-mentioned graft mixture in the liquid. At room temperature using gamma rays ( 60 Co, irradiation dose is 5kGy) radiation grafting for 46 hours. The nonwoven fabric was taken out, rinsed with water, dried in an oven at 40°C, and the grafting rate was measured by the above-mentioned method, and the result was 10%.

[0098] 3. Performance test

[0099] The blood leukocyte residual rate, leukocyte removal rate and hemolysis rate of this product were measured by the above method, and the result leukocyte...

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Abstract

The invention discloses a leukocyte filtering membrane, a manufacturing method and applications thereof. The leukocyte filtering membrane comprises a polybutylene terephthalate (PBT) non-woven fabric base material with a surface density of 50-200 g / m2 and grafting modifiers, which are grafted on the non-woven fabric base material, wherein the grafting modifier is selected from acrylic acid, methacrylic acid, vinyl pyrrolidone, and heparin or is a mixture composed of two or more of the components mentioned above; and the grafting rate of the grafting modifier is 5 to 15 wt%.

Description

technical field [0001] The present invention relates to a novel filter membrane for removing leukocytes, which has high leukocyte removal rate and low hemolysis rate. The present invention also relates to the manufacturing method of the leukocyte filter membrane and its application in filtering and removing leukocytes. Background technique [0002] Platelet blood components are widely used in blood diseases, tumors and surgical operations, and are in short supply. [0003] Studies have shown that if there are many remaining leukocytes in the platelet preparation (PC), repeated infusions can cause the alloimmune reaction of the recipient's leukocyte antigen system (HLA), and produce tolerance to the reinfusion of blood and related products, that is, " Blood transfusions are invalid." The academic community agrees that 90% of alloimmune reactions are caused by antibodies to the leukocyte antigen system. If leukocytes are filtered from blood products so that the number of re...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D71/48B01D61/00D06M14/34D06M10/10
Inventor 叶寅王衡东蔡锡明
Owner 上海世龙科技有限公司
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