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Method for inducing primate macular degeneration model by high fat

A technology for primates and macular degeneration, which is applied in the field of high-fat-induced macular degeneration models of primates, can solve problems such as differences in eye structure, pathogenesis process and pathological characteristics, excessive growth factors, and Bruch's membrane damage. The effect of stable and irreversible model, good taste and good compliance

Active Publication Date: 2015-10-21
广西南宁灵康赛诺科生物科技有限公司
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Problems solved by technology

There are also: model gene modified mouse animal model, surgically induced choroidal neovascularization model, etc., but the ADM models provided at present all have the following deficiencies: (1) select non-primates such as mice and rats as models, non-primate There are species differences between primates and human ADM, and their eye structure, pathogenesis process and pathological characteristics are quite different from those of humans; (2) Bruch's membrane is destroyed; (3) excessive growth factors are produced
At present, there is no ideal animal model that can fully simulate the development of human macular degeneration

Method used

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  • Method for inducing primate macular degeneration model by high fat
  • Method for inducing primate macular degeneration model by high fat
  • Method for inducing primate macular degeneration model by high fat

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Embodiment Construction

[0026] The present invention will be further described below in conjunction with specific examples, but the protection scope and application scope of the present invention will not be limited.

[0027] 1. Main instruments and test materials

[0028] 1. Main instruments:

[0029] (1) Fundus camera: purchased from Topcon, Japan.

[0030] (2) OCT tester: purchased from Heidelberg, Germany.

[0031] (3) Fundus fluorescein angiography: purchased from Japan Topcon Corporation.

[0032] 2. Test material:

[0033] (1) The preparation method of basal feed comprises the following steps:

[0034] a. Take rice, soybean, and soybean meal, pulverize them respectively, and pass through a 60-mesh sieve to obtain crushed rice flour, soybean flour, and soybean meal powder;

[0035] b. Take 0.1kg of vitamin E and 8kg of soybean oil, mix them evenly, add flour according to the method of equal increase, mix evenly, and pass through a 60-mesh sieve to obtain evenly dispersed flour mixture A; ...

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Abstract

The present invention discloses a method for inducing a primate macular degeneration model by high fat. The method comprises: feeding an inhuman primate suffered from drusen lesion with a high-fat feed and feeding the inhuman primate for three times every day with the feeding amount of 75-100g per time; and feeding the inhuman primate for 60-110 days to obtain a stable macular degeneration model. According to the method disclosed by the present invention, a dry or wet macular degeneration animal model close to spontaneous occurring of human beings can be obtained and the integrity of a Bruch's film can be kept; the model is stable and irreversible, and has good animal obedience; animals do not need to be subjected to surgeries or be killed to be checked; the modeling cost is very low; and an ideal animal model is provided for researching a pathogenesis of the macular degeneration model, screening treatment medicines and carrying out pharmacodynamic evaluation.

Description

technical field [0001] The invention relates to a method for establishing animal disease models, in particular to a method for high-fat-induced macular degeneration models of primates. Background technique [0002] Macular degeneration is a chronic eye disease, and its pathological mechanism is mainly the aging change of the macular area of ​​the eye. It can be divided into age-related macular degeneration (also called age-related macular degeneration, ADM) and juvenile macular degeneration kind. ADM is a degenerative disease that occurs in the retinal pigment epithelium, Bruch's membrane, and choroidal capillaries, and its prevalence increases with age. Common reasons, with the acceleration of my country's aging population, the disease has a clear upward trend. ADM is divided into two types: dry and wet. Dry ADM is also called atrophic or non-exudative AMD, and wet is also called exudative AMD. Dry AMD is characterized by progressive atrophy or atrophy of the retinal pigm...

Claims

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Application Information

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IPC IPC(8): A01K67/02A23K1/14A23K1/10A23K1/16A23K1/18
CPCA01K67/02Y02P60/87
Inventor 张国栋岳峰张周泉
Owner 广西南宁灵康赛诺科生物科技有限公司
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