A method for high-fat induced primate macular degeneration model

Abstract

The present invention discloses a method for inducing a primate macular degeneration model by high fat. The method comprises: feeding an inhuman primate suffered from drusen lesion with a high-fat feed and feeding the inhuman primate for three times every day with the feeding amount of 75-100g per time; and feeding the inhuman primate for 60-110 days to obtain a stable macular degeneration model. According to the method disclosed by the present invention, a dry or wet macular degeneration animal model close to spontaneous occurring of human beings can be obtained and the integrity of a Bruch's film can be kept; the model is stable and irreversible, and has good animal obedience; animals do not need to be subjected to surgeries or be killed to be checked; the modeling cost is very low; and an ideal animal model is provided for researching a pathogenesis of the macular degeneration model, screening treatment medicines and carrying out pharmacodynamic evaluation.

Description

technical field [0001] The invention relates to a method for establishing animal disease models, in particular to a method for high-fat-induced macular degeneration models of primates. Background technique [0002] Macular degeneration is a chronic eye disease, and its pathological mechanism is mainly the aging change of the macular area of ​​the eye. It can be divided into age-related macular degeneration (also called age-related macular degeneration, ADM) and juvenile macular degeneration kind. ADM is a degenerative disease that occurs in the retinal pigment epithelium, Bruch's membrane, and choroidal capillaries, and its prevalence increases with age. Common reasons, with the acceleration of my country's aging population, the disease has a clear upward trend. ADM is divided into two types: dry and wet. Dry ADM is also called atrophic or non-exudative AMD, and wet is also called exudative AMD. Dry AMD is characterized by progressive atrophy or atrophy of the retinal pigm...

AI Technical Summary

Problems solved by technology

There are also: model gene modified mouse animal model, surgically induced choroidal neovascularization model, etc., but the ADM models provided at present all have the following deficiencies: (1) select non-primates such as mice and rats as models, non-primate There are species differences between primates and human ADM, and their eye structure, pathogenesis process and pathological characteristics are quite different from those of humans; (2) Bruch's membrane is destroyed; (3) excessive growth factors are produced

At present, there is no ideal animal model that can fully simulate the development of human macular degeneration

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