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Application of 20(s)-protopanaxadiol in the preparation of anti-anxiety drugs

A protopanaxadiol and anti-anxiety technology, which can be used in drug combinations, pharmaceutical formulations, medical preparations containing active ingredients, etc., and can solve problems such as no patent reports yet.

Active Publication Date: 2019-03-26
SHANGHAI INNOVATIVE RESEARCH CENTER OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] So far, there has been no patent report on the treatment of anxiety with 20(S)-protopanaxadiol

Method used

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  • Application of 20(s)-protopanaxadiol in the preparation of anti-anxiety drugs
  • Application of 20(s)-protopanaxadiol in the preparation of anti-anxiety drugs
  • Application of 20(s)-protopanaxadiol in the preparation of anti-anxiety drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Example 1: Detection of the effect of 20(S)-protopanaxadiol against m-clophenylpiperazine (mCPP)-induced anxiety model in mice with elevated plus maze

[0040] 1. Experimental animals: Kunming mice, male, 25-30 grams, provided by Shanghai Slack Experimental Animal Co., Ltd., license number: SCXK (Shanghai) 2007-0005.

[0041] 2. Experimental drug and preparation:

[0042]20(S)-protopanaxadiol: Shanghai Traditional Chinese Medicine Innovation Research Center, batch number 20050606-1, purity 94%; during experiment, prepare according to the following method: take 20(S)-protopanaxadiol, add specific solvent ( Ethanol: castor oil: the volume ratio of water is 1:10:89) to make a suspension, and make it into the required concentration;

[0043] Panaxadiol group total saponins (PDS), Shanghai Traditional Chinese Medicine Innovation Research Center, batch number 20070806, the preparation method is the same as 20(S)-protopanaxadiol during the test; diazepam, purchased from Shang...

experiment example 2

[0072] Experimental Example 2: Detecting the effect of 20(S)-protopanaxadiol against m-clophenylpiperazine (mCPP)-induced anxiety model in mice by light and dark box

[0073] 1. Experimental animals: the same as in Example 1.

[0074] 2, experimental medicine and preparation: with embodiment 1.

[0075] 3. Grouping of animals, administration method and dosage: the same as in Example 1.

[0076] 4. Experimental method:

[0077] The light and dark boxes include a light box and a dark box, with a transitional space in between. The mice in each group were adapted to the light and dark box for 2 minutes / mouse the day before the test. On the day of the test, 20 minutes after subcutaneous injection of mCPP or the corresponding solvent, the mice were placed in the light box area of ​​the light and dark box, and the software analysis system automatically recorded the time when the animal entered the light area and dark area within 5 minutes, and the number of visits.

[0078] 5. St...

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PUM

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Abstract

The invention relates to a new use of 20(S)-protopanaxadiol, and concretely relates to an application of 20(S)-protopanaxadiol in the preparation of anxiolytic drugs. An experiment result displays that the 20(S)-protopanaxadiol can treat anxiety, and has a better treatment effect than drugs in the prior art.

Description

technical field [0001] The present invention relates to a new application of 20(S)-protopanaxadiol, in particular to the application of 20(S)-protopanaxadiol in preparing anti-anxiety drugs. Background technique [0002] Protopanaxadiol is the in vivo metabolite of ginsenosides in the diol group, which is divided into 20-(S)-protopanaxadiol (20(S)-protopanaxadiol, 20(S)-dammarane-24-ene-3β, 12β ,20-triol) and 20(R)-protopanaxadiol (20(R)-protopanaxadiol, 20(R)-dammarane-24-ene-3β,12β,20-triol), which are mutual Enantiomers, whose structures are as follows: [0003] [0004] The prior art discloses the pharmacological action research progress of 20(S) protopanaxadiol (Mao Jingjing et al., 20(S)-protopanaxadiol pharmacological action research progress, Chinese Journal of Experimental Formulas, Volume 24 in 2011) 20( S)-Protopanaxadiol has many pharmacological activities such as anticancer, antidepressant, activating chloride ion channels and inhibiting the depolarization ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/575A61P25/22
Inventor 许长江张文静韩琪园虞沁澜汪沁琳杨子荣惠永正
Owner SHANGHAI INNOVATIVE RESEARCH CENTER OF TRADITIONAL CHINESE MEDICINE
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