94 results about "Anti anxiety" patented technology

A method of therapeutically administering certain medicaments in order to maximize the desired effects and minimize the unwanted metabolite effects on the human body, including the central nervous system, in order to maximize therapeutic effects, such as anti-anxiety, anticonvulsant and hypnotic effects, and minimize unwanted side effects, such as ataxic and incoordination effects, of the medicament. Also, a method of inhalation administration or skin administration of certain medicaments in order to decrease metabolism of the medicaments to unwanted metabolites.

The present disclosure provides a unit dosage form with an anxiolytic dosage of zopiclone particularly eszopiclone. Also provided is a method for treatment or prophylaxis of anxiety using a subsedative dosage of zopiclone particularly eszopiclone.

The invention discloses a Chinese medicinal composition with the effects of antidepressant and anti-anxiety, and belongs to the field of Chinese traditional medicines. The Chinese medicinal composition comprises (by weight parts) radix bupleuri 6-15, cape jasmine fruit 5-15 or paeonia suffruticosa bark 5-20, and angelica sinensis 3-15 or ligusticum chuanxiong 3-15; and can be prepared into any conventional oral preparations. Different ministerial drugs and adjuvant drugs are added according to different subjects to better exert therapeutic effect. The inventive composition has the effects of antidepressant and anti-anxiety; and can be used for relieving depression and anxiety with the advantages of definite therapeutic effect and rapid drug effect. The inventive composition can also be used for relieving headache, palpitation, insomnia and melancholia.

Mice in which OCT3 expression is suppressed were successfully constructed by administering antisense against OCT3 gene into the brain. Mice in which OCT3 expression is suppressed display phenotypes related to mental disorders such as anti-depression and anti-anxiety, and therefore the mice can be applied to the screening of therapeutic agents for mental disorders. In addition, substances suppressing the OCT3 expression or function were shown to be in fact effective as therapeutic agents for depression and anxiety neuroses.

The present invention provides novel compositions in the form of a powder, capsule, liquid or lozenge, and methods for administering said novel compositions to assist the body in its ability to maintain a reasonable homeostatic mechanism for compensating for chronic internal acidity. The composition may contain several active ingredients, such as potassium bicarbonate, citric acid, calcium citrate, magnesium citrate, glycine, and licorice. The composition may also contain other inactive excipients, such as hypoallergenic rice, flour, glycerine, tangerine oil and gelatin. Following oral administration, the composition is rapidly broken down and absorbed into the systemic circulation. Upon absorption, the individual components are able to assist the physiological acid-alkaline buffer systems, promote anti-anxiety effects, and decrease inflammation in the digestive system.

The invention discloses a pharmaceutical composition with the effects of hypnosis, anti-depression and anti-anxiety, and belongs to the traditional Chinese medicine field. The pharmaceutical raw materials of the pharmaceutical composition are: 6 to 40 parts by weight of Szechuan lovage rhizome and 10 to 40 parts by weight of pinellia tuber which are taken as monarch drugs; and 3 to 20 parts by weight of cape jasmine fruit or 1 to 15 parts by weight of golden thread which are taken as ministcrial drugs. The pharmaceutical composition can be prepared into any common preparation form for internal usage. The different adjuvant drugs or guide drugs can be added on the basis of the monarch drugs and the ministcrial drugs according to the different individual differences, so as to play the better efficacy. The pharmaceutical composition of the invention has the effects of hypnosis, anti-depression and anti-anxiety, the efficacy for the treatment of insomnia, depression and anxiety disorder is exact, the onset of action is fast, and the pharmaceutical composition can also be used for the treatment of insomnia, melancholia, headache, palpitation and other diseases of the traditional Chinese medicine.

The invention provides to an anti-anxiety medicine by using a rheum officinate root extract as an active ingredient. The anti-anxiety medicine uses the rheum officinate root extract as the active ingredient and can be made into various oral administration formulations such as tablet, granules, capsule, oral liquor, etc.; other components and supplementary materials can be added to form a compound preparation; and the anti-anxiety medicine has evident anti-anxiety effect and can be used for health and treatment of anxiety disorder. Moreover, the invention further provides health food prepared from the rheum officinate root extract and food additives, and preparation methods of the medicine and the food.

The invention discloses a benzo-aza-alkyl aryl piperazine derivative and applications in preparation of drugs. The derivative shows the effect on central nervous systems, especially on the double highaffinity activity of a 5-HT<1A> acceptor and a Sigma-1 acceptor. Various physiological and pharmacological effects are brought into play in the body; and the compound can be used as a pharmaceuticalactive substance, especially used for anti-depression, anti-anxiety, anti-bipolar affective disorder and anti-neuropathic pain, and can also be used as an intermediate to prepare other pharmaceuticalactive compounds. The compound is fast in effect and small in toxic and side effect, and can meet demands of clinical applications; and the compound is a compound or a free base or salt thereof havingthe following structural formula (IV). The structure of the compound or the free base or salt thereof is shown as the structural formula (IV).

The present invention comprises compositions comprising combinations of kava extract compositions in combination with one or more anxiolytics and methods for treating conditions related to the various anxiety disorders comprising administering the compositions of the present invention. The invention further provides methods for enhancing the therapeutic activity of an anxiolytic comprising administering the anxiolyitc in combination with extract of Piper methysticin.

The invention provides a pharmaceutical composition comprising a 5-HT1A receptor stimulant and a mood stabilizer. In the pharmaceutical composition, the weight ratio of the 5-HT1A receptor stimulant to the mood stabilizer is (1-40):(50-800). The invention also provides application of the pharmaceutical composition. Through combination of selective 5-HT1A receptor stimulant and the mood stabilizer which have different action mechanisms, the drug can treat anxiety, depression and/or biphasic emotional disorder and the like at the same time; the disease treatment spectrum is wider; furthermore, the curative effect after combination is more significant than that of single medicine, and the toxic and side effects are lower; a novel drug selection is provided to patients who are intolerant to first-line anti-anxiety or anti-depression or drugs.

Provided are an agent for the treatment and/or prophylaxis of an anxiety disorder comprising, as an active ingredient, a thiazole derivative represented by the formula (I) wherein R¹ represents aryl or the like, and R² represents pyridyl or the like, or a pharmaceutically acceptable salt thereof, and the like.

The invention includes methods for treating tobacco addiction and nicotine addiction of patients, alleviating nicotine withdrawal symptoms, providing or promoting curative effect of smoking cessation treatment and as long-term smoking cessation maintenance treatment. The invention also relates to a pharmaceutical composition comprising a nicotine receptor antagonist and an antidepressant or an anxiolytic. A specific combination of drugs (mecamylamine hydrochloride and bupropion hydrochloride) and a pharmaceutical composition formed by combining mecamylamine with certain types of drugs (such as anxiolytics and antidepressants) are disclosed. These compositions are also contemplated for use in the treatment of cocaine addiction and the treatment of alcohol dependence.

The present invention relates to obovatol compound isolated from Magnolia obovata Thunb. for the prevention and treatment of anxiety disorders involved with CNS. The obovatol compound isolated from Magnolia obovata Thunb. have potent anti-anxiety activity, verified by an increased percentage of time on the open arms, an increased number of entries into, time spent on, the distal portion of the open arms, and a decreased activity of locomotor. Therefore it can be used as the therapeutics or health care food for treating and preventing anxiety disorders.

This invention provides a highly safe anti-anxiety composition that can be used for treatment or prevention of anxiety disorders. Such anti-anxiety composition comprises, as an active ingredient, a carotenoid.

The invention discloses a traditional Chinese medicine composition for treating mental anxiety. Generalized anxiety is a clinical common type, characterized by chronic anxiety and easy to recur and difficult to cure. Anxiety disorder has the main symptoms of fear and tension lacking definite objects and concrete contents, and is accompanied with vegetative nerve symptoms, muscular tension and motion disturbance of patients. On treatment, medicaments with anti-anxiety effects, such as benzodiazepines, tricyclic compounds, SSRIS (selective serotonin reuptake inhibitors) and the like are adopted generally, but the side reactions are relatively large. Anxiety disorder can be classified according to the aetiological agents into types of stagnation of the liver-qi, deficiency of both heart and spleen, deficiency of heart blood, moist heat in both liver and gall and deficiency of both qi and blood by differentiation of symptoms and signs in traditional Chinese medicine. The traditional Chinese medicine composition for treating mental anxiety is capable of soothing the liver and relieving depression, arresting convulsion and soothing nerves, and is used for treating mental depression, panic insomnia, chest distress and other symptoms. The traditional Chinese medicine composition is prepared from bupleurum, angelica, chuanxiong rhizome, tuckahoe, uncaria, multiflower knoweed stem, fried bighead atractylodes rhizome and licorice. In the prescription, the bupleurum is bitter in taste and cool in nature, has good efficacies on treating alternate attacks of chills and fever, fullness sensation in chest, hypochondriac pain, bitter taste, deafness, headache, dizziness and the like. The traditional Chinese medicine composition can alleviate patients from the suffering of mental anxiety and reduce the economic burden on patients. The traditional Chinese medicine composition is a pure traditional Chinese medicine oral preparation, and can be safely taken for a long term.

The present disclosure relates to compositions that provide anti-anxiety relief and similar benefits and use thereof. In particular, the disclosure provides compositions containing omega-3 fatty acids concentrates, cannabanoids and L-Theanine, and the synergistic effects of these compositions provides multiple health and wellness benefits. The disclosure further provides the use of these compositions in addressing multiple indications for health and wellness, including but not limited to, sleeplessness, anxiety, pain associated with general inflammation, drug addiction, brain injury, and/or alpha wave brain disorder.

The present invention is a device for delivering a low frequency magnetic field pulse (Cnp) to affect the physiological and/or neurological conditions of an animal or human. In particular, distinct Cnps are designed to have anti-depression, analgesic, or anti-anxiety effects. These Cnps may be applied in combination in a sequence.

The invention discloses a detection method of an anti-anxiety pharmaceutical composition and a detection method of capsules of the anti-anxiety pharmaceutical composition. The method is characterized by using high performance liquid chromatography (HPLC) to detect and carrying out linear relation test, precision test, repeatability test, stability test and recovery test and a series of tests. The detection method of the invention is accurate and effective, and can well control the product quality.

The invention belongs to the field of medicines and pharmaceutics, and relates to a midazolam combination, a preparation method of the midazolam combination, and the application of the midazolam combination. Specifically, the midazolam combination comprises 2.5 to 8.0 percent (g/ml) of midazolam, 5 to 30 percent (g/ml) of cyclodextrin and 30 to 80 percent (ml/ml) of polyols through being calculated according to the total volume of the midazolam combination, wherein the cyclodextrin is carefully selected from one or more of beta cyclodextrin, hydroxypropyl-beta cyclodextrin, gamma cyclodextrin, dimethyl beta cyclodextrin, trimethyl beta cyclodextrin, hydroxypropyl beta cyclodextrin and HE-beta cyclodextrin; and the polyols are selected from one or more of propylene glycol, glycerol, polyoxyethylene castor oil and polyethylene glycol. The concentration of the midazolam in the combination can reach above 25mg/ml and the pH (potential of hydrogen) value of the midazolam is between 4.5 and 10.0. The invention additionally relates to the preparation method of the combination and the application of the combination during the preparation of medicines for curing epilepsy and achieving the effects of anti-anxiety, sedation, peaceful sleeping, muscular relaxation or anti-convulsion.

The invention relates to application of coptis and alkaloid thereof in preparation of an anti-anxiety medicament. The problem that the coptis or the alkaloid is applied in preparation of the anti-anxiety medicament can be effectively solved. The invention adopts the technical scheme that: the coptis is decocted into coptis decoction by adding water, or the coptis is extracted by using ethanol, then coptis alkaloid is prepared by using water bath, and the coptis water bath fluid or the coptis alkaloid is subjected to mouse cross maze or light and dark box passing experiments; and the experiment results show that the coptis and the alkaloid thereof have anti-anxiety effect. The application can expand the medicinal value of the coptis, and is an innovation on the anti-anxiety medicament.