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Clotrimazole cream and preparation method thereof

A clotrimazole and ointment technology, applied in the field of preparation of clotrimazole ointment, can solve the problems of excessive microorganisms, unsatisfactory treatment effect, increased side effects and irritation, etc., so as to protect the wound surface, shorten the treatment period and ensure quality effect

Inactive Publication Date: 2015-11-04
GUANGDONG SHUNFENG PHARMA
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  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

But most of the clotrimazole creams currently on the market are 1% clotrimazole creams. Because the main drug concentration is low, the prescription ratio is simple, and the therapeutic effect is not particularly ideal. If the main drug concentration is increased to 3%, then It may increase side effects and irritation; at the same time, the conventional preparation method of cream preparation adopts the method of heating the water and oil phases to a certain temperature (about 80°C) and then mixing them evenly, and there is a risk of microorganisms exceeding the standard

Method used

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  • Clotrimazole cream and preparation method thereof
  • Clotrimazole cream and preparation method thereof
  • Clotrimazole cream and preparation method thereof

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Embodiment 1

[0028] Clotrimazole emulsifiable paste of the present invention, every 1000 grams comprises the component of following weight:

[0029] Clotrimazole 10g, Benzyl Alcohol 15g, Stearyl Alcohol 60g, Glyceryl Monostearate 65g, White Petrolatum 60g, Liquid Paraffin 35g, Glycerin 100g, Pinpinga-O 40g, Chlorhexidine Acetate 5g, Edetate Disodium 0.5 g, the balance is water.

[0030] The preparation method of above-mentioned clotrimazole cream comprises the following steps:

[0031] S1. Take stearyl alcohol, glyceryl monostearate, white petrolatum, and liquid paraffin and heat to 100°C, stir to melt completely, keep warm for 15 minutes, cool to 95°C, add clotrimazole and benzyl alcohol, stir to completely melt Dissolve, cool to 75°C, set aside;

[0032] S2. Take glycerin, Pingpinga-O, disodium edetate, chlorhexidine acetate and water and heat to 100°C, stir to dissolve completely, keep warm for 15 minutes, cool to 75°C, and set aside;

[0033] S3, under isothermal conditions at 75°C,...

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Abstract

The invention discloses clotrimazole cream and a preparation method thereof. The clotrimazole cream comprises components in percentage by mass as follows: 1% of clotrimazole, 17%-34% of oleaginous bases, 4%-6% of an emulsifying agent, 5%-10% of a moisturizer, 1.1%-3% of a preservative, 0.03%-0.05% of a complexing agent and the balance of water. According to the clotrimazole cream, the antibacterial drug clotrimazole with the concentration of 1% is reasonably proportioned with components such as the preservative with antibacterial activity and the like, so that the antibacterial drug plays the important role, can improve the trichomonas killing effect, can be used for treating bacterial vaginitis, trichomonas vaginitis, senile vaginitis, male balanitis, penis itching and the like clinically, and enlarges the treatment range.

Description

technical field [0001] The invention relates to a clotrimazole cream medicine, which belongs to the technical field of pharmaceutical preparations, in particular to a preparation method of a clotrimazole cream medicine. Background technique [0002] Vaginitis is a common and frequently-occurring disease in gynecology, concentrated in women before puberty to menopause, mainly occurs in women of childbearing age, the incidence rate is as high as more than 70%, directly affects the physical and mental health, daily life and work of women in general. Among them, fungal vaginitis is the most common clinical vaginitis, which is caused by the excessive growth of fungi in the vaginal epithelium. As a broad-spectrum pyrrole antifungal drug, clotrimazole has good antibacterial effect on various fungi, especially Candida albicans. Its mechanism of action is to inhibit the synthesis of fungal cell membrane and affect its metabolic process. Clotrimazole metabolizes slowly in the body. ,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K31/4174A61P15/02A61P31/10A61P31/04A61P33/02
Inventor 潘红炬冯韵华林琪珊麦文培廖志刚梁勇坤余良钟王北明柴将红
Owner GUANGDONG SHUNFENG PHARMA
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