The invention discloses a detoxification, anti-inflammatory and vagina-shrinking pill for gynaecology. The vagina-shrinking pills are prepared from the following traditional Chinese medicine materialsin parts by weight: 12-16 parts of danshen roots, 12-16 parts of fructus cnidii, 12-16 parts of sophora flavescens, 3-4 parts of saffron crocus, 8-10 parts of mint, 8-10 parts of golden cypress, 8-10parts of solidago decurrens, 8-10 parts of radix stemonae, 8-10 parts of madurasa roots in Indonesia, 8-10 parts of seabuckthorn, 8-10 parts of arnebia seeds, 8-10 parts of Chinese angelica, 8-10 parts of curcuma zedoary, 8-10 parts of aloes, 8-10 parts of dahurian angelica roots, 8-10 parts of eaglewood, 8-10 parts of pearl powder, 8-10 parts of gingko fruits, 8-10 parts of white peony, and 4-5parts of borneol. The invention also provides a preparation method of the vagina-shrinking pills. The vagina-shrinking pill is a pure traditional Chinese medicine preparation, and has the effects of detoxification, anti-inflammatory, removing putrefaction, generating muscle, and activating and nourishing cells, the common symptoms such as irregular menstruation, dysmenorrhea, gynecological inflammation can be obviously improved, female private part is promoted to restore firmness, and the pill is convenient to use and quick to work, does not damage the acid-base balance of the internal environment, has no side effects, and does not rebound.