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Disinfectant with antimicrobial peptides Cbf-14, and preparation and application of disinfectant

A technology of cbf-14 and disinfectant, which is applied in the direction of disinfectant, medical preparations containing active ingredients, antibacterial drugs, etc., can solve the problems of respiratory irritation, environmental pollution, irritating odor, etc., and extend the validity period Effect

Active Publication Date: 2015-11-11
CHINA PHARM UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The commonly used disinfectants are generally chemical disinfectants, which have pungent smell, strong corrosiveness, irritation to the respiratory tract, damage to furniture, electrical appliances, metal objects, etc., and also have certain pollution to the environment.
If in order to reduce irritation, reduce the content of chemical disinfection ingredients, but its ability to kill bacteria and fungi will be greatly reduced, and it cannot meet the national standard of disinfectants

Method used

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  • Disinfectant with antimicrobial peptides Cbf-14, and preparation and application of disinfectant
  • Disinfectant with antimicrobial peptides Cbf-14, and preparation and application of disinfectant
  • Disinfectant with antimicrobial peptides Cbf-14, and preparation and application of disinfectant

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0094] Preparation of Disinfectant Spray Containing Polypeptide Cbf-14

[0095] Weigh 200 mg of antibacterial peptide Cbf-14 into a clean dry beaker, add 300 mL of sterile water, stir until dissolved, then add 50 mL of PEG400, 10 mL of isomeric alcohol polyoxyethylene ether, 80 mL of glycerin, and finally add sterile water to 1 L , stirred evenly, sterilized by filtration (filtered with a 0.22 μm membrane filter), and poured into a sterile spray bottle.

[0096] The components of the pharmaceutical composition preparation are as follows:

[0097]

Embodiment 2

[0099] Preparation of Disinfectant Spray Containing Polypeptide Cbf-14

[0100] Weigh 300 mg of antibacterial peptide Cbf-14 into a clean dry beaker, add 300 mL of sterile water, stir until dissolved, then add 100 mL of PEG400, 10 mL of isomeric alcohol polyoxyethylene ether, 50 mL of glycerin, and finally add sterile water to 1 L , stirred evenly, sterilized by filtration (filtered with a 0.22 μm membrane filter), and poured into a sterile spray bottle.

[0101] The components of the pharmaceutical composition preparation are as follows:

[0102]

Embodiment 3

[0104] Preparation of Disinfectant Spray Containing Polypeptide Cbf-14

[0105] Weigh 200mg of antibacterial peptide Cbf-14 into a clean dry beaker, add 300mL of sterile water, stir until dissolved, then add 200mL of PEG400, 20mL of isomeric alcohol polyoxyethylene ether, 50mL of glycerin, and finally add sterile water to 1L , stirred evenly, sterilized by filtration (filtered with a 0.22 μm membrane filter), and poured into a sterile spray bottle.

[0106] The components of the pharmaceutical composition preparation are as follows:

[0107]

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PUM

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Abstract

The invention relates to the field of disinfection products, and particularly discloses preparation and application of disinfection spray with 14 antimicrobial peptides Cbf-14 of amino acid. The disinfection spray which is a disinfectant comprises the antimicrobial peptides Cbf-14, polypeptide protective agents, skin moistening agents and zwitterionic surfactants. The preparation and the application have the advantages that the disinfectant is mainly in a spray dosage form and can be used for disinfection treatment on postoperative wound surfaces, nursing on operative wound, disinfection treatment on skins of traumatic wound surfaces, disinfection nursing on skins injured due to burning, scalding, scorching and bruising, disinfection treatment on operation instruments and general disinfection nursing on skins and mucosae; the disinfection spray is excellent in bactericidal activity for gram positive bacteria, gram negative bacteria and fungi, is nontoxic, is free of irritation and is a skin and mucosa disinfection product.

Description

technical field [0001] The invention relates to the technical field of disinfectant research and application thereof, and in particular provides a prescription development, preparation method and application of a disinfectant containing antibacterial peptide Cbf-14. Background technique [0002] Disinfectants are mainly used to kill pathogenic microorganisms in the transmission medium to make them harmless, eliminate pathogenic microorganisms outside the human body, cut off the transmission route of infectious diseases, and achieve the purpose of controlling infectious diseases. Currently commonly used disinfectants are generally chemical disinfectants, which have a pungent smell, strong corrosiveness, irritation to the respiratory tract, damage to furniture, electrical appliances, metal objects, etc., and also pollute the environment to a certain extent. If the content of chemical disinfection ingredients is reduced in order to reduce irritation, its ability to kill bacteri...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/10A61K47/34A61K47/10A61P31/04A61P17/02A01P1/00
Inventor 周长林贾源宾余昌仲韩小荣窦洁
Owner CHINA PHARM UNIV
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