The invention relates to a high-power neutral electrolyte metal-air battery system and a using method thereof. The battery system comprises two or a plurality of basic cell units connected in series or in parallel, an electrolyte filtering box, a circulating pump, a control valve, an electrolyte input distributor, an electrolyte discharge manifold, a drain valve, an electrolyte overflow manifold,a control circuit, a controller, a connecting pipeline and the like. Each basic cell unit consists of a reaction box, an anode, a cathode, electrolyte, a cathode busbar and an anode busbar; and an electrolyte input port, an electrolyte discharge port and an electrolyte overflow exhaust port are formed at both sides of the reaction box. The electrolyte is neutral liquid, such as salt water, seawater and the like. The electrolyte of each basic cell unit is communicated with each other without using an electrolyte isolator. The high-power neutral electrolyte metal-air battery system and the usingmethod thereof, which are disclosed by the invention, are applicable to the high-power power utilization requirements and have the characteristics that after the anodes are used up, the anodes can bereplaced so as to reuse the high-power neutral electrolyte metal-air battery system; the high-power neutral electrolyte metal-air battery system can be stored for long time in a safe and maintenance-free mode, and is simple to start up and use; a load can be cut off at any time; the high-power neutral electrolyte metal-air battery system and the using method thereof have no pollution to the environment; and reaction precipitates can be recovered and recycled.