Preparation method for mixed three templates molecularly imprinted solid phase extraction column and application thereof
A technology of solid-phase extraction column and template molecule, which is applied in the preparation of mixed three-template molecularly imprinted solid-phase extraction column and the preparation of molecularly imprinted polymer, which can solve the problems of high selectivity, high adsorption capacity, and inability to display.
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Embodiment 1
[0066] Example 1 A preparation method of a mixed three-template molecularly imprinted solid-phase extraction column
[0067] In this example, the preparation of the mixed three-template molecularly imprinted solid-phase extraction column was carried out according to the following sequence of steps:
[0068] ⑾ dissolve
[0069] Dissolve 1 mol of bifentriazole, 1 mol of cyhalothrin and 1 mol of atrazine in 550 L of porogen acetonitrile, and then add 18 mol of functional monomer α-methacrylic acid to obtain A1 ;
[0070] ⑿Prepolymerization
[0071] Put A1 at a frequency of 200Hz for 60min and put it in a refrigerator at 4°C for 6h to obtain B1;
[0072] ⒀ Polymerization
[0073] Add 45 mol of cross-linking agent ethylene glycol dimethacrylate and 2 mol of initiator azobisisobutyronitrile to B1, after ultrasonication at a frequency of 200 Hz for 30 min, inject high-purity nitrogen gas for 10 min, and seal the container to obtain C1;
[0074] Place C1 at 60°C and react in a ...
Embodiment 2-6
[0082] Example 2-6 Preparation method of mixed three-template molecularly imprinted solid-phase extraction column
[0083] Examples 2-6 are respectively a preparation method of a mixed three-template molecularly imprinted solid-phase extraction column. The preparation process is similar to that of Example 1, the only difference is that the corresponding technical parameters in the preparation process are different, and the specific results See Table 1 .
[0084] Table 1 Technical parameters during the preparation of mixed triple-template molecularly imprinted solid-phase extraction columns
[0085]
[0086] Examples 2-6 have simple preparation methods, easy control of the process, and low cost. The imprinted polymer can be directly loaded into the column without grinding. The column has good stability, high strength, acid and alkali resistance, and the imprinted polymer in the column has specific spatial positions. , can achieve specific adsorption.
Embodiment 7
[0087] Example 7 Selection of Functional Monomer and Screening Test of Template Molecule and Functional Monomer Ratio
[0088] In this example, the selection of functional monomers and the ratio of template substances to functional monomers were explored during the polymerization process. In this embodiment, ultraviolet spectroscopy is used to scan the ultraviolet spectrum of the mixed three-template substance-MAA system and the mixed three-template substance-AM system.
[0089] Prepare a certain concentration of MAA-acetonitrile solution (MAA is α-methacrylic acid) and AM-acetonitrile solution (AM is acrylamide) and mixed three-template substance-acetonitrile solution, and prepare a mixed acetonitrile solution of functional monomer and template substance , so that the molar concentration ratio is 1:0, 1:2, 1:4, 1:6, 1:8, 1:10 respectively, and the ultraviolet spectrum scanning is carried out between the wavelength 190-300nm.
[0090] (1) If the template substance does not ...
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