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Anti-inflammatory active ingredients of Hainan dischidia chinensis water extract and application

A technology of water extracts and active ingredients, applied in the field of traditional Chinese medicine, can solve the problems of insufficient development and application of oysteria, and achieve the effects of reasonable operation and simple process

Inactive Publication Date: 2015-11-18
HAINAN MEDICAL COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In order to solve the above insufficient problems in the development and application of Rhizoma Eurythiae, the present invention provides an anti-inflammatory active ingredient of the aqueous extract of Rhizoma Rhizoma

Method used

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  • Anti-inflammatory active ingredients of Hainan dischidia chinensis water extract and application
  • Anti-inflammatory active ingredients of Hainan dischidia chinensis water extract and application
  • Anti-inflammatory active ingredients of Hainan dischidia chinensis water extract and application

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Experimental program
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Effect test

Embodiment 1

[0025] Embodiment 1: water extraction

[0026] 1 material

[0027] 1.1 Drugs and reagents Dischidiachinensis Champ was collected from the crater of Haikou City, Hainan Province, and was identified by Dai Haofu, a researcher at the Institute of Biology, Chinese Academy of Tropical Agricultural Sciences. .exBenth) whole plant. Aspirin enteric-coated tablets (Jiangsu Pingguang Pharmaceutical Co., Ltd., batch number: 140801); Evans blue (BS, 5g, Aladdin Reagent Shanghai Co., Ltd.); 0.9% sodium chloride injection (pharmaceutical grade, Hunan Jinjian Pharmaceutical Industry limited liability company); carboxymethylcellulose (AR, 500g / bottle, Sinopharm Chemical Reagent Factory); xylene (AR, 500mL / bottle, Tianjin Damao Pharmaceutical Chemical Reagent Factory); n-butanol, ethyl acetate and Petroleum ether was analytically pure. 1.2 Animals Kunming mice, clean grade, weighing 18-22 g, provided by Changsha Tianqin Biotechnology Co., Ltd., experimental animal use license number: SCXK (...

Embodiment 2

[0055] Take 5kg of dry Sapia praecox, crush it and pass it through a 40-mesh sieve, soak it in 30 times the amount of water overnight, then extract it with ultrasonic waves for 2 hours, the ultrasonic frequency is 40-50KHz, and the temperature is 70-80°C. After ultrasonic extraction for 1.5 hours, turn on at the same time Decoct in water for a total of 30 minutes, repeat the above-mentioned soaking, ultrasonication, and decoction 3 times, cool, filter, combine the filtrates, and concentrate under reduced pressure to an extract to obtain 229.5 g of water extract with a recovery rate of 4.59%. Take an appropriate amount of water extract and add 10 times of water to suspend to obtain a suspension, which is sequentially extracted with ethyl acetate, n-butanol, and petroleum ether. The volume ratios of ethyl acetate, n-butanol, petroleum ether and the suspension are 1:1, respectively. The extraction time was 10 min, respectively, and concentrated under reduced pressure to obtain eth...

Embodiment 3

[0057] Take 5kg of dry Sapia praecox, crush it and pass it through a 40-mesh sieve, soak it in 30 times the amount of water overnight, then extract it with ultrasonic waves for 2 hours, the ultrasonic frequency is 40-50KHz, and the temperature is 70-80°C. After ultrasonic extraction for 1.5 hours, turn on at the same time Decocting for a total of 30 minutes, repeating the above-mentioned soaking, ultrasonication, and decocting 3 times, cooling, filtering, combining the filtrates, and concentrating under reduced pressure to an extract form to obtain 229.5 g of water extract with a recovery rate of 4.59%. Take an appropriate amount of water extract and add 8 times of water to suspend to obtain a suspension, and then extract it with ethyl acetate, n-butanol, and petroleum ether. The volume ratios of ethyl acetate, n-butanol, petroleum ether and the suspension are 1:2, respectively. The extraction time was 6 minutes respectively, and concentrated under reduced pressure to obtain et...

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Abstract

The invention relates to the technical field of traditional Chinese medicines and in particular relates to anti-inflammatory active ingredients of a Hainan dischidia chinensis water extract. The active ingredients are obtained through the following steps: soaking dischidia chinensis in water overnight, carrying out ultrasonic-assisted extraction, decoction and extraction, mixing filtrates and carrying out vacuum concentration to obtain a water extract; adding water to suspend the water extract to obtain suspension and extracting the suspension with ethyl acetate, n-butyl alcohol, petroleum ether and a solvent mixture in sequence, thus obtaining various extracts respectively. The anti-inflammatory active ingredients have the beneficial effects that the anti-inflammatory active ingredients are simple in process and reasonable in operation; meanwhile, anti-inflammatory effective parts of the dischidia chinensis alcohol extract can be obtained, which is a new discovery in the anti-inflammatory effect of the natural product, Hainan dischidia chinensis; theoretical and experimental bases are provided for clinical application of dischidia chinensis to treatment of expectoration due to lung dryness, hemoptysis, pertussis, infantile malnutrition, dysentery, toxins and pus of scabies, pain and swelling from injuries from falls and venomous snake bites.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine, in particular to an anti-inflammatory active ingredient of the water extract of the hainan tree lotus, and also relates to the application of the anti-inflammatory active ingredient of the water extract of the hainan tree lotus. Background technique [0002] Dischidia chinensis (scientific name: Dischidia chinensis) is an epiphytic vine of the genus Dischidia chinensis in the Radixaceae family. It is a unique plant in China. In my country, it is mainly distributed in Hainan, Guangdong, Guangxi and other provinces and regions. In Hainan, it is mainly produced in Ledong, Sanya, Baoting and other places, and grows in mountainous forest valleys or open fields at low to middle altitudes. The whole plant of the lotus eye tree is used as medicine, which has the effect of clearing the lungs and reducing phlegm, cooling blood and detoxification. It is used in the folk to treat dryness...

Claims

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Application Information

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IPC IPC(8): A61K36/27A61P29/00
CPCY02A50/30
Inventor 杨柳余邦良王小蒙张军于春伟姚瑰玮陈湛娟
Owner HAINAN MEDICAL COLLEGE
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