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Mulberry dichloromethane extract as well as preparation method and application thereof

A technology of mulberry dichloromethane and dichloromethane, which is applied in the field of mulberry dichloromethane extract and its preparation, can solve problems that have not yet been retrieved, and achieve a product suitable for large-scale industrial production, strong anti-inflammatory activity, and simple preparation method Effect

Active Publication Date: 2015-11-25
SHENZHEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Although a large number of literatures have reported that different extracts of mulberry have strong anti-inflammatory and anti-cancer activities, the extraction of anti-inflammatory active ingredients of mulberry dichloromethane extract and related research reports have not yet been retrieved.

Method used

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  • Mulberry dichloromethane extract as well as preparation method and application thereof
  • Mulberry dichloromethane extract as well as preparation method and application thereof
  • Mulberry dichloromethane extract as well as preparation method and application thereof

Examples

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Embodiment 1

[0027] Embodiment 1 A kind of preparation method of mulberry dichloromethane extract

[0028] The preparation method of the mulberry dichloromethane extract of this embodiment comprises the following specific steps:

[0029] (1) 3.5Kg of fresh mulberries, washed and dried naturally for excess water, added 80% ethanol solution acidified with 0.1% hydrochloric acid, after homogenization, reacted at 25±5°C and 100KPa, filtered after 24 hours, and collected the filtrate , repeat this step three times, mix the three times of filtrate, recover ethanol under reduced pressure at 50±5°C, concentrate the filtrate to a small volume, transfer the concentrated filtrate to a small container, and rotary evaporate to dryness at 50±5°C until the quality of the concentrate remains Constant, weighed to obtain the initial extract 412.67g.

[0030] (2) Take 370.13g of the initial extract, dissolve it completely with water, then add an equal volume of water-saturated dichloromethane, mix upside do...

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Abstract

The invention discloses a mulberry dichloromethane extract as well as a preparation method and an application thereof. The mulberry dichloromethane extract is extracted from mulberry by adopting an acidified alcohol method and an organic solvent extraction method. The mulberry dichloromethane extract has relatively high anti-inflammatory activity in cell level, and has a significant alleviation effect on mice colonitis; and the mulberry dichloromethane extract disclosed by the invention is simple in preparation method and suitable for large-scale industrial production, and is expected to be developed into novel anti-inflammatory health products.

Description

technical field [0001] The invention belongs to the technical field of plant extraction, more specifically, the invention relates to a dichloromethane extract of mulberry and its preparation method and application. Background technique [0002] Inflammation is an adaptive response caused by pathogenic bacteria, harmful stimuli or physical injury, and is a defense measure produced by the body against infection or tissue damage. In the early stage of inflammation, this defense mechanism is beneficial. Inflammatory cells release corresponding inflammatory factors and carry out a series of defensive responses to injury factors, such as dilution and killing. At the same time, the released inflammatory factors participate in Repair and healing of damaged parts of the body; when the inflammatory response is too severe or prolonged, the beneficial inflammation of the body will change, and in turn induce various inflammation-related diseases, and even evolve into chronic or persisten...

Claims

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Application Information

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IPC IPC(8): A61K36/605A23L1/29A61P1/00A23L33/00
Inventor 苟德明康康吴志琴王立岩李荔黄炼
Owner SHENZHEN UNIV
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