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Long-acting antibacterial absorbable surgical suture

A suture, long-acting technology, used in the field of medical sutures, can solve the problems of skin tissue inflammation, prolong the healing period, bacterial infection of wounds, etc., achieve good cell compatibility, increase antibacterial properties, and eliminate scars.

Active Publication Date: 2015-11-25
安徽省康宁医疗用品有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As a foreign body, the suture exists in the incision tissue, and it is easy to cause an inflammatory reaction in the skin tissue. The sutured wound is easily infected by bacteria in the surrounding environment of the body, which will cause the wound to prolong the healing period due to bacterial infection. Therefore, it is necessary to provide a A suture thread with long-acting sustained-release antibacterial effect

Method used

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  • Long-acting antibacterial absorbable surgical suture

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Effect test

Embodiment 1

[0020] A long-acting antibacterial absorbable medical suture, the raw materials of which include by weight: 100 parts of carboxymethyl chitosan, 10 parts of polylactic acid, 20 parts of polyglycolide, 8 parts of hyaluronic acid, and 15 parts of eel skin collagen , 10 parts of salmon collagen, 10 parts of silk fibroin, 2 parts of sorbitol, 3 parts of sucrose, 3 parts of tea tree oil, 2 parts of alkydated starch, 3 parts of dicyclohexylcarbodiimide, 0.8 parts of glutaraldehyde, 2 parts of paint share;

[0021] Among them, the preparation method of the coating is: mix the aqueous solution of carboxymethyl chitosan with a mass fraction of 4wt% and the aqueous solution of sodium alginate with a mass fraction of 2wt%, stir at a speed of 600r / min for 20min, add chlorogenic acid, and stir at a speed of 600r / min. Stir at a speed of 1 min to dissolve, filter, and vacuum defoam to obtain solution A, wherein the volume of carboxymethyl chitosan solution and sodium alginate solution is 1:4...

Embodiment 2

[0023] A long-acting antibacterial absorbable medical suture, the raw materials of which include by weight: 80 parts of carboxymethyl chitosan, 20 parts of polylactic acid, 10 parts of polyglycolide, 12 parts of hyaluronic acid, and 10 parts of eel skin collagen , 15 parts of salmon collagen, 8 parts of silk fibroin, 4 parts of sorbitol, 2 parts of sucrose, 5 parts of tea tree oil, 1 part of alkydated starch, 5 parts of dicyclohexylcarbodiimide, 0.4 parts of glutaraldehyde, 6 parts of paint share;

[0024] Among them, the preparation method of the coating is: mix the aqueous solution of carboxymethyl chitosan with a mass fraction of 2wt% and the aqueous solution of sodium alginate with a mass fraction of 4wt%, stir at a speed of 400r / min for 40min, add chlorogenic acid, and stir at a speed of 400r / min. Stir at a speed of 1 min to dissolve, filter, and vacuum defoam to obtain solution A, wherein the volume of carboxymethyl chitosan solution and sodium alginate solution is 1:1, ...

Embodiment 3

[0026] A long-acting antibacterial absorbable medical suture, the raw materials of which include by weight: 85 parts of carboxymethyl chitosan, 17 parts of polylactic acid, 13 parts of polyglycolide, 11 parts of hyaluronic acid, and 11 parts of eel skin collagen , 13 parts of salmon collagen, 8.5 parts of silk fibroin, 3.5 parts of sorbitol, 2.2 parts of sucrose, 4.5 parts of tea tree oil, 1.2 parts of aldehydized starch, 4.5 parts of dicyclohexylcarbodiimide, 0.5 parts of glutaraldehyde, 5 parts of paint share;

[0027]Wherein, the preparation method of coating is: the mass fraction is that 2.5wt% carboxymethyl chitosan aqueous solution is mixed with mass fraction is 3.5wt% sodium alginate aqueous solution, stirs 35min with the speed of 450r / min, adds chlorogenic acid, with Stir at a speed of 450r / min to dissolve, filter, and vacuum defoam to obtain solution A, wherein the volume of carboxymethyl chitosan solution and sodium alginate solution is 1:2, and the volume of chlorog...

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Abstract

The invention discloses a long-acting antibacterial absorbable surgical suture. The long-acting antibacterial absorbable surgical suture comprises, by weight, 80-100 parts of carboxymethyl chitosan, 10-20 parts of polylactic acid, 10-20 parts of polyglycollide, 8-12 parts of hyaluronic acid, 10-15 parts of eel skin collagen, 10-15 parts of trout collagen, 8-10 parts of silk fibroin, 2-4 parts of sorbitol, 2-3 parts of saccharose, 3-5 parts of tea tree oil, 1-2 parts of aldelhydic starch, 3-5 parts of dicyclohexylcarbodiimide, 0.5-0.7 part of glutaraldehyde and 2-6 parts of coating. The long-acting antibacterial absorbable surgical suture has the advantages of good antibacterial and anti-inflammatory properties, no organic solvent, little environmental pollution, good compatibility with biological tissues, easiness for cell adhesion and cell proliferation and good mechanical property.

Description

technical field [0001] The invention relates to the technical field of medical sutures, in particular to a long-acting antibacterial and absorbable medical sutures. Background technique [0002] Surgical suture refers to a special thread used for wound ligation, suture hemostasis and tissue suture in surgical operations. According to its biodegradability, it can be divided into two categories: non-absorbable thread and absorbable thread. Absorbable sutures include natural fibers and synthetic polymer sutures. [0003] Chitosan is a natural fiber suture with good biocompatibility, antibacterial ability, chemical inertness, and no foreign body reaction to tissues. Inflammation, and has the advantages of anti-inflammatory, promoting wound healing, smooth wound after healing, but chitosan has poor mechanical properties and poor solubility. Carboxymethyl chitosan is a chitosan derivative with good water solubility and strong antibacterial properties. [0004] Surgical incisio...

Claims

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Application Information

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IPC IPC(8): A61L17/12A61L17/08A61L17/14D01F8/18D01F8/14D01F8/02D01F1/10D06M15/13D06M15/03D06M13/123D06M101/10D06M101/32D06M101/14
Inventor 祁建兵
Owner 安徽省康宁医疗用品有限公司
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