Compounds with fungus resistance and antineoplastic activity and preparation method and application thereof

A technology of anti-tumor activity and anti-fungal drugs, which is applied in the field of medicine, can solve problems such as treatment failure and human side effects, and achieve the effect of convenient clinical use
CN105085221AActive Publication Date: 2015-11-25NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
Publication Date
2015-11-25

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Abstract

The invention discloses compounds with fungus resistance and antineoplastic activity and a preparation method thereof. The chemical components of selaginella pulvinate are researched systematically and deeply; as shown by spectrum and mass spectrum data analysis, a compound A and a compound B with novel structures are obtained by separating from the selaginella pulvinate. as shown by fungus resistance and antineoplastic activity research in vitro, the compound A and the compound B have obvious inhibiting effects on multiple pathomycetes, comprising candida albicans, smoke-colored aspergillus, red trichophyta, alpha fungus and the like. The compound B has obvious inhibitory activity on leukemia, lung cancer, gastric cancer, nasopharyngeal carcinoma, liver cancer and cervical cancer tumours and the like. The compounds can be conveniently prepared into multiple dosage forms and is convenient to take clinically.
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Description

technical field

[0001] The present invention relates to a compound with antifungal activity, in particular to a compound with antifungal and antitumor activity extracted from Selaginella genus Selaginella and its application in treating fungal infections and tumor diseases. It belongs to the field of medical technology. Background technique

[0002] Malignant tumors are frequently-occurring and common diseases that seriously endanger human health and life. In many countries including China, especially moderately developed countries, the death caused by malignant tumors ranks first or second only to cardiovascular diseases, and the morbidity and mortality are still on the rise worldwide. The successful research of paclitaxel and other drugs shows that it is of great significance to continue to find cytotoxic drugs or lead compounds with new mechanisms of action and unique chemical structures from natural plants, which has become an important field and research hotspot in can...

Claims

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