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Kit for detecting liver fibration and liver cirrhosis

A liver fibrosis and kit technology, applied in the field of biomedicine, can solve problems such as no reports

Active Publication Date: 2015-11-25
HANGZHOU PROPRIUM BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] However, there is no report on the relationship between the level of CHI3L1 in blood and liver fibrosis and cirrhosis in biological samples after HBV infection, which is common in the Chinese population.

Method used

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  • Kit for detecting liver fibration and liver cirrhosis
  • Kit for detecting liver fibration and liver cirrhosis
  • Kit for detecting liver fibration and liver cirrhosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0099] 1. Clinical trials

[0100] 1.1 Sample source: Serum samples and normal controls collected from the First Affiliated Hospital of Zhejiang University School of Medicine, the Second Affiliated Hospital of Zhejiang University School of Medicine and Run Run Shaw Hospital Affiliated to Zhejiang University School of Medicine were diagnosed as liver cirrhosis caused by HBV infection Serum samples, the samples are serum stored below -80°C within 1 year or below -20°C within 1 month. Quantitative determination of CHI3L1 using assessment reagents; compare the clinical or pathological diagnosis results of liver cirrhosis in clinical units, use the ROC curve to determine the appropriate positive reference value, and evaluate the specificity, sensitivity, total coincidence rate and correlation of the detection kit. gender analysis.

[0101] 1.2 Sample selection basis, inclusion criteria, exclusion criteria and exclusion criteria

[0102] Inclusion criteria: the remaining serum sam...

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Abstract

The invention discloses a kit for detecting liver fibration or liver cirrhosis caused by hepatitis B virus infection. Whether an individual has liver fibration or liver cirrhosis conditions or not is determined through detecting the level of CHI3L1 in an individual sample. The kit includes: (1) an antibody bound to the CHI3L1; (2) a labeled antibody bound to the CHI3L1 when the CHI3L1 is bound to the antibody limited in (1); and (3) a standard sample composed of a solution containing a known amount of the CHI3L1, wherein the CHI3L1 is from serum of a liver fibration or liver cirrhosis patient caused by the hepatitis B virus infection.

Description

technical field [0001] The invention belongs to the technical field of biomedicine. Specifically, the present invention relates to a kit for detecting liver fibrosis and / or liver cirrhosis, in particular to a kit for detecting the level of CHI3L1 in a sample. Background technique [0002] Cirrhosis refers to the advanced stage of liver fibrosis. It is defined morphologically as diffuse hepatic fibrosis with abnormal nodular formation. Only diffuse fibrosis without nodule formation (such as congenital hepatic fibrosis), or only nodule formation without fibrosis (such as nodular regenerative hyperplasia) cannot be called cirrhosis. From a clinical point of view, liver cirrhosis refers to liver failure caused by the above-mentioned liver histopathological changes (decreased serum albumin, decreased cholinesterase activity, increased bilirubin, prolonged prothrombin time, etc.) and Portal hypertension (esophageal and gastric varices and their rupture and bleeding, ascites, sp...

Claims

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Application Information

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IPC IPC(8): G01N33/68
CPCG01N33/68
Inventor 林标扬
Owner HANGZHOU PROPRIUM BIOTECH
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