A dual-mode cardiac in situ perfusion system

A dual-mode, heart-based technology, applied in the field of medical devices, can solve problems such as uneven distribution, short local maintenance time, hemangioma formation and inflammatory response, and achieve high safety, long-term perfusion, and improved utilization Effect

Active Publication Date: 2018-04-24
GENERAL HOSPITAL OF PLA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Direct intramyocardial injection avoids side effects such as first-pass effect and hypotension of intravascular injection, and has the advantages of high local drug concentration and good targeting. , and disadvantages such as uneven distribution, hemangioma formation and inflammatory reaction

Method used

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  • A dual-mode cardiac in situ perfusion system
  • A dual-mode cardiac in situ perfusion system
  • A dual-mode cardiac in situ perfusion system

Examples

Experimental program
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Embodiment Construction

[0041] as attached figure 1 As shown, the present invention provides a dual-mode cardiac in situ perfusion system, including a perfusion catheter, an infusion connection tube, a pressure sensor, a hydraulic pump, a physiological recorder and a signal discriminator;

[0042] Wherein, the perfusion catheter includes an outer cladding layer 1 and an inner tube I3 and an inner tube II5 inside the outer cladding layer, and the outer surfaces of the inner tube I3 and inner tube II5 are completely covered by the outer cladding layer 1, such as attached figure 2As shown, its overall shape is made up of straight section 6 and crotch section 7, and described crotch section 7 is made up of arc section and straight section, and arc section and straight section 6 join; image 3 As shown, the end of the inner tube I3 corresponding to the straight section is closed and has a side opening 4, the end of the inner tube II5 is open, and the side opening of the inner tube I3 runs through the ou...

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Abstract

The invention discloses a double-mode heart in-situ perfusion system and belongs to the technical field of medical instruments. The system comprises a perfusion guide pipe, an infusion connecting pipe, a pressure sensor, a hydraulic pump, a physiological recorder and a signal discriminator. The tail ends of two inner pipes in a straight section portion of the perfusion guide pipe are connected with the hydraulic pump and the pressure sensor through the infusion connecting pipe respectively, the inner pipe with the tail end closed and the lateral side open is communicated with a pump outlet of the hydraulic pump, the inner pipe with the tail end open is communicated with the pressure sensor, the pressure sensor transmits measured pressure signals to the signal discriminator, the physiological recorder transmits human electrocardiograph signals to the signal discriminator, and the signal discriminator processes the electrocardiograph signals or the pressure signals and then sends a starting or stopping signal to the hydraulic pump to control perfusion time. The double-mode heart in-situ perfusion system can realize long-time perfusion of cell factors or stem cells and has the advantages of safety, easiness in operation and high targeting ability, and treatment effect of ischemic heart failure is improved.

Description

technical field [0001] The invention relates to a perfusion system for realizing drug administration for ischemic heart disease, in particular to a dual-mode cardiac in situ perfusion system, which belongs to the technical field of medical devices. Background technique [0002] Ischemic heart disease is a common disease that seriously threatens human health. Current conventional treatments have limited curative effect. Stem cell transplantation and cytokine infusion have shown great potential in the treatment of ischemic heart disease, but they need to play a therapeutic role in situ to avoid uptake and utilization of peripheral non-target tissues. [0003] Traditional cardiac drug delivery methods include intracoronary injection, intramyocardial injection, subepicardial intramyocardial injection transplantation, and intravenous injection. [0004] Subendocardial intramyocardial injection transplantation: determine the location and extent of myocardial infarction through en...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61M31/00
Inventor 何昆仑陈韵岱易军
Owner GENERAL HOSPITAL OF PLA
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