Application of RAG2 gene knockout rat in establishing personalized tumor treatment model

A gene knockout and RAG2 technology, applied in animal husbandry and other fields, can solve problems such as ethical restrictions, high cost, inconvenient operation, etc., and achieve the effect of high tumor formation rate, short cycle and simple process
CN105145486AInactive Publication Date: 2015-12-16INST OF LAB ANIMAL SCI CHINESE ACAD OF MEDICAL SCI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
INST OF LAB ANIMAL SCI CHINESE ACAD OF MEDICAL SCI
Publication Date
2015-12-16
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses application of a RAG2 gene knockout rat in establishing a personalized tumor treatment model. The personalized humanized RAG2 gene knockout rat tumor treatment model is successfully established by transplanting tumor tissues of a patient by using the RAG2 gene knockout rat as a carrier. In the treatment model, tumor models with different abnormal paths are established, so that the condition of the tumor disease of the patient is trustily simulated. Drugs and treatment methods with tumor-resisting functions are evaluated by virtue of characteristics of each patient. The method for establishing the personalized tumor treatment model by virtue of the RAG2 gene knockout rat is simple in step, and the established RAG2 gene knockout rat tumor treatment model has the advantages of being short in period, high in tumor formation rate and low in expense, and can be used for forming tumors for different types of tumor tissues, so that the model can be widely applied to personalized treatment of tumors.
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Description

technical field

[0001] The invention relates to the application of RAG2 gene knockout rats in establishing individualized tumor treatment models. Background technique

[0002] Tumor is one of the most threatening diseases to human beings. Compared with other diseases, the effective rate of clinical treatment of tumor is still low. With the continuous deepening of human genomics, pharmacogenomics and tumor molecular biology research, researchers have a more comprehensive understanding of the characteristics of multiple causes and heterogeneity of tumors. Genome sequencing studies have found that there are few gene mutation duplications among tumors of the same pathological type; the gene mutation spectrum among different individuals of the same type of tumor is very different, which is the biological basis for the different clinical phenotypes of tumors of the same pathological type , It is also the reason why different individuals of the same type of tumor respond very diff...

Claims

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