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A cyclodextrin-like metal-organic framework compound and its preparation method and application

A metal-organic framework, cyclodextrin technology, applied in the direction of organic active ingredients, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., to achieve the effect of no toxic and side effects

Inactive Publication Date: 2018-07-24
JINING UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the inclusion of drug molecules using cyclodextrin metal-organic framework materials has not been reported

Method used

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  • A cyclodextrin-like metal-organic framework compound and its preparation method and application
  • A cyclodextrin-like metal-organic framework compound and its preparation method and application
  • A cyclodextrin-like metal-organic framework compound and its preparation method and application

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preparation example Construction

[0025] The embodiment of the present invention also provides a preparation method of a cyclodextrin metal organic framework compound, comprising the following steps:

[0026] S1. Weigh a certain amount of β-CD and prepare its saturated solution with distilled water at 80-90°C, then cool to room temperature and filter to obtain β-CD crystals;

[0027] S2. Step S1 was repeated three times, and the obtained β-CD crystals were vacuum-dried at 100° C. to obtain β-cyclodextrin crystals;

[0028] S3. Weigh 1.135g (1mmol) of β-cyclodextrin and 0.320g (8mmol) of sodium hydroxide obtained in step S2 into 10mL water containing 40% (V 乙醇 :V 水 =6:4) in ethanol solution, stirred at room temperature for 30min to obtain a mixed solution;

[0029] S4. Transfer the mixed solution obtained in step S3 to a 15mL polytetrafluoroethylene low-pressure reactor, and perform a constant temperature reaction at 100° C. for 3 days to obtain a reactant;

[0030] S5. Cool the reaction product obtained in ...

Embodiment

[0037] Preparation of ASP-Na-CD-MOF inclusion compound

[0038]The clathrate of aspirin is prepared by the grinding method, the specific steps are as follows: Add anhydrous methanol to a certain amount of Na-CD-MOF and grind it into a paste at a specified temperature (30, 40, 50°C), then slowly add methanol Dissolved aspirin solution, triturated mixture for indicated times (1, 2, 3 h). The clathrate was washed three times with a small amount of anhydrous methanol, and freeze-dried to obtain a loose ASP-Na-CD-MOF clathrate powder, which was placed in a desiccator for future use. Prepare 3 copies in parallel.

[0039] According to the pre-experimental method, the inclusion rate of aspirin was used as the investigation index, and L 9 (3 4 ) was carried out in an orthogonal design experiment to investigate the influence of the feed ratio (A) of ASP and Na-CD-MOF, the inclusion temperature (B), the dropping time (C) and the inclusion time (D) of four factors, Choose three level...

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Abstract

The invention discloses a cyclodextrin metal-organic framework compound and its preparation method and use. The cyclodextrin metal-organic framework compound has a chemical formula of Na(C42H64O35). 11H2O (Na-CD-MOF), is a monoclinic crystal and has a P2<1> space group and cell parameters of a=15.2372(5)A, b=10.5956(5)A, c=20.2018(5)A, alpha=Y=90.0371, beta=108.2235 degrees and V=3097.91719A<3>. The crystal has a white color and comprises one beta-cyclodextrin, one Na<+> ion and eleven crystal water molecules. The invention prepares the novel degradable Na-beta-cyclodextrin metal-organic framework molecule without toxic or side effect on the human body. Through a grinding method, the ASP-Na-CD-MOF clathrate is prepared.

Description

technical field [0001] The invention relates to the technical field of cyclodextrin metal organic framework compounds, in particular to a metal organic framework compound and its preparation method and application. Background technique [0002] Metal-organic frameworks (MOFs) compounds, as a new type of functional molecular material, have the characteristics of structural flexibility and easy functionalization unmatched by other materials. In recent years, MOFs have shown many characteristics required as drug carriers, including extremely high specific surface area and large pore size capable of loading drug molecules, biodegradability caused by relatively unstable coordination bonds between metals and organic ligands, etc. properties have become important candidate materials for drug storage and delivery, and scientists place great expectations on them. [0003] Cyclodextrin (CD) is a general term for a series of cyclic oligosaccharides produced by amylose under the action...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08B37/16A61K31/616A61K47/69
Inventor 沙靖全钟晓华陆洪军李淑贤
Owner JINING UNIV
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