Traditional Chinese medicinal preparation for treating post-traumatic brain syndrome and preparation method thereof

A technology for the sequelae of traumatic brain injury and traditional Chinese medicine preparations, which is applied in the directions of pharmaceutical formulations, medical preparations containing active ingredients, and drug combinations, etc., can solve the problems of low absorption rate of active ingredients, etc., and achieve full medicinal effect and high content of fat-soluble ingredients. Effect

Inactive Publication Date: 2015-12-23
孔德华
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The invention overcomes the shortcomings of traditional oral decoctions, tablets and granules with low absorption rate of active ingredients, and more than 95% of the drugs absorbed into the blood cannot pass through the blood-brain barrier to exert curative effect, and prepares a nasal spray administered through the nasal mucosa agent

Method used

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  • Traditional Chinese medicinal preparation for treating post-traumatic brain syndrome and preparation method thereof
  • Traditional Chinese medicinal preparation for treating post-traumatic brain syndrome and preparation method thereof
  • Traditional Chinese medicinal preparation for treating post-traumatic brain syndrome and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] 1. Prepare the raw medicinal materials according to the recommended prescription

[0049]

[0050] 2. Extract the active ingredients in raw medicinal materials:

[0051] ① Precisely weigh the crude drug according to the above-mentioned recommended components, and crush it into a coarse powder, sieve it, and set aside.

[0052] ② Before putting the medicinal materials into the percolation barrel, use 60% ethanol as a solvent to moisten the medicinal materials to make them fully expand, so as to prevent the medicinal materials from expanding in the barrel, causing the medicinal materials to be too tight and causing uneven percolation. The wetting time is 30 minutes.

[0053] ③Packing of medicinal materials into the column should be added in stages, and each time it should be evenly flattened, suitable for tightness, and uniform around, and the amount of powder loaded in the percolation cylinder should not exceed 2 / 3 of the volume.

[0054] ④ After loading the column, ...

Embodiment 2

[0070] 1. Prepare the raw medicinal materials of the recommended prescription with Example 1.

[0071] 2. Extract the active ingredients of the crude medicinal material with the example 1.

[0072] 3. Prepared as nasal mucosal spray:

[0073] 1) Spray formula:

[0074] Drug powder 20-30%

[0075] Sodium Benzoate 0.05%

[0076] Fatty acid glycerides 0.5%

[0077] Polyoxyethylene (40) stearate (Myrj-52): 0.5%

[0078] Tetrafluoroethane (HFA-134a): 69.95~79.95%

[0079] 2) The specific preparation method of the spray is the same as in Example 1.

Embodiment 3

[0081] 1. Prepare the raw medicinal materials of the recommended prescription with Example 1.

[0082] 2. Extract the active ingredients of the crude medicinal material with the example 1.

[0083] 3. Prepared as nasal mucosal spray:

[0084] 1) Spray formula:

[0085] Drug powder 20-30%

[0086] Sodium Benzoate 0.05%

[0087] Fatty acid glycerides 0.5%

[0088] Polyoxyethylene (40) stearate (Myrj-52): 0.5%

[0089] Decafluoropropane (HFA-227): 69.95~79.95%

[0090] 3) The specific preparation method of the spray is the same as in Example 1.

[0091] In order to further illustrate the clinical efficacy of the drug, 100 patients were selected for clinical treatment, and the subjects were non-selectively divided into a test group and a control group, with 50 people in each group. There were 25 males and females in the test group and the control group; the average age of the test group was 47.53 years old, the course of disease was 3-6 months, 19 cases were concussion, and...

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Abstract

The invention belongs to the technical field of traditional Chinese medicines and in particular relates to a traditional Chinese medicinal preparation for treating a post-traumatic brain syndrome and a preparation method thereof. Multiple traditional Chinese medicinal materials, namely dragon blood, frankincense, myrrh, sappanwood and caulis spatholobi, capable of promoting circulation and removing stasis are adopted, effective ingredients are extracted through percolation and are prepared into active medicinal micro powder, and the extracted effective medicinal ingredients are prepared into nasal spray, so that medicines can be distributed on nasal mucosa; and the nasal mucosa has unique natural relation with brain in an anatomical physiology structure, so that intranasal administration can bypass a blood brain barrier, the medicines are distributed in a central nerve system, and action effect and curative effect of the medicines are improved.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine preparation for treating sequelae of brain trauma and a preparation method thereof. Background technique [0002] Post-traumatic brain syndrome, also known as post-traumatic brain syndrome, refers to a group of autonomic nervous dysfunction or mental symptoms that exist for a long time in patients with traumatic brain injury after the recovery period. Symptoms include headache, nervousness, irritability, difficulty concentrating, memory impairment, dizziness, insomnia, and fatigue. The neurological examination was unremarkable, and the neuroradiological examination was negative. If this group of symptoms persists without improvement for more than three months after traumatic brain injury, it is post-traumatic brain syndrome. Usually these patients have mild or moderate blunt head trauma without serious neurologica...

Claims

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Application Information

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IPC IPC(8): A61K36/889A61K36/896A61K9/12A61P25/00
Inventor 孔德华
Owner 孔德华
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