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Miracle fruit branch extract and its application in the preparation of medicines or health care products with hypoglycemic or hypolipidemic effects

The technology of extract and miracle fruit, applied in the field of natural medicinal chemistry, can solve the problem of unclear effective components of hypoglycemic effective parts, and achieve the effect of significant hypoglycemic effect, hypolipidemic and hypoglycemic effect.

Active Publication Date: 2019-07-02
广东龙飞生物有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But still there is no specific report claiming that the hypoglycemic and hypolipidemic effect of Miracle Fruit branch, more do not utilize the report of Chinese medicine modernization technology to prepare effective part, those skilled in the art still do not know the effective part and active ingredient of hypoglycemic, hypolipidemic in Miracle Fruit branch It is not clear, and how to prepare effective parts with good hypoglycemic and hypolipidemic effects still needs research and exploration

Method used

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  • Miracle fruit branch extract and its application in the preparation of medicines or health care products with hypoglycemic or hypolipidemic effects
  • Miracle fruit branch extract and its application in the preparation of medicines or health care products with hypoglycemic or hypolipidemic effects

Examples

Experimental program
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Effect test

Embodiment 1

[0019] Weigh 1 kg of dried miracle fruit branches and crush them, then heat and reflux them with 5 kg of ethanol for 2 times, each time for 1.5 hours, combine the extracts, and concentrate to obtain the miracle fruit branch ethanol extract; then place the miracle fruit branch ethanol extract in supercritical CO 2 In the extractor, control the pressure in the supercritical carbon dioxide extractor to be 30 MPa, the temperature to be 40° C., the flow rate to be 20 liters / hour, and the extraction time to be 2 hours to obtain supercritical CO2 2 Extract 95.7g.

Embodiment 2

[0021] Weigh 1 kg of dried miracle fruit branches and crush them, then heat and reflux them with 5 kg of ethanol for 2 times, each time for 1.5 hours, combine the extracts, and concentrate to obtain the miracle fruit branch ethanol extract; then place the miracle fruit branch ethanol extract in supercritical CO 2 In the extractor, control the pressure in the supercritical carbon dioxide extractor to be 40 MPa, the temperature to be 50° C., the flow rate to be 30 liters / hour, and the extraction time to be 2 hours to obtain supercritical CO2 2 Extract 90.3g.

Embodiment 3

[0023] Weigh 40 g of the extract obtained in Example 1, dissolve it with ethyl acetate, mix the sample with 40 g of silica gel (100-200 mesh), and take another 800 g of silica gel (200-300 mesh) for dry packing, and load the sample On the column, first use 3 times the column volume of cyclohexane: acetone mixed solvent with a volume ratio of 93:7 to elute; then use 8 times the column volume to elute with a volume ratio of 90:10 cyclohexane: acetone mixed solvent ; Collect the cyclohexane with a volume ratio of 90:10: the elution site of the mixed solvent of acetone, concentrate and dry the extract 8.8g.

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Abstract

The invention relates to the technical field of natural pharmaceutical chemistry, and particularly discloses a miracle fruit branch extract and application thereof to preparation of drugs or health care products with an effect of regulating the blood sugar level or reducing blood fat. The extract is obtained by preparing according to a following method: firstly smashing a miracle fruit branch, extracting by using an organic solvent to obtain an organic solvent extract, and then extracting by adopting a supercritical carbon dioxide extraction method. The extract has very remarkable effects of regulating the blood sugar level and reducing blood fat, and can be used for preparing the drugs or the health care products with the effect of regulating the blood sugar level or reducing blood fat.

Description

technical field [0001] The invention relates to the technical field of natural medicine chemistry, in particular to a miraculous fruit branch extract and its application in the preparation of medicines or health care products with hypoglycemic or hypolipidemic effects. Background technique [0002] Miracle fruit, whose Latin scientific name is Synsepalum dulcificum Daniell, is a typical tropical evergreen shrub native to West Africa, Ghana, and Congo. In the 1960s, when Premier Zhou Enlai visited West Africa, the Republic of Ghana gave the mysterious fruit to Premier Zhou as a national gift. Since then, the miracle fruit began to be cultivated in our country. [0003] Patent CN102743421A discloses a branch and leaf extract of Miracle Fruit, which is reported to have antioxidant and anti-gout effects. But still there is no specific report claiming that the hypoglycemic and hypolipidemic effect of Miracle Fruit branch, more do not utilize the report of Chinese medicine moder...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/185A23L33/105A61P3/10A61P3/06
Inventor 禤文生王国才
Owner 广东龙飞生物有限公司