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A kind of anti-infection soft tissue medical glue and preparation method thereof

A soft tissue, anti-infection technology, applied in the field of medical devices, can solve the problems of infection with blood-borne diseases, long coagulation time, unfavorable treatment, etc., to avoid drug resistance, the preparation method is simple and convenient, and it is suitable for large-scale production.

Active Publication Date: 2018-01-26
CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This type of adhesive has good biocompatibility and degradability, but the adhesion is low, the setting time is long, which is not conducive to treatment, and there is also a risk of infection of blood-borne diseases

Method used

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  • A kind of anti-infection soft tissue medical glue and preparation method thereof
  • A kind of anti-infection soft tissue medical glue and preparation method thereof
  • A kind of anti-infection soft tissue medical glue and preparation method thereof

Examples

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preparation example Construction

[0029] The raw materials for the preparation of the anti-infective soft tissue medical glue provided by the present invention include plant polyphenols, which are preferably selected from one or more of tannic acid, catechin, morin and gallol, more preferably selected from One or more of tannic acid, catechin and morin. In the present invention, the plant polyphenols contain catechol units, and the catechol units can be hydrogen-bonded with electron-donating groups in water-soluble polymers and electrostatically combined with protonated antibiotics in physiological environments, making anti-infection Soft tissue medical glue has higher bonding strength, better biocompatibility, and better hemostatic performance.

[0030] The preparation raw material of the anti-infection soft tissue medical glue provided by the present invention comprises water-soluble polymer, and described water-soluble polymer is preferably selected from polyethylene glycol, polyoxyethylene-polyoxypropylene...

Embodiment 1

[0052] Add 5 g of tannic acid and 5 mL of ultrapure water to No. 1 beaker, and dissolve by ultrasonication at 30°C for 15 minutes to obtain 5 mL of 1 g / mL tannic acid aqueous solution. Add M to No. 2 beaker n 5 g of 10 kDa polyethylene glycol, 5 mL of ultrapure water, and ultrasonically dissolve at 30°C for 15 minutes to obtain 5 mL of 1 g / mL polyethylene glycol aqueous solution. Add 0.5 g of gentamicin sulfate and 1 mL of ultrapure water to No. 3 beaker, and dissolve by ultrasonication at 30°C for 15 minutes to obtain 1 mL of 0.5 g / mL gentamicin sulfate aqueous solution.

[0053] Add 2.5mL of 1g / mL polyethylene glycol aqueous solution and 1mL of 0.5g / mL gentamicin sulfate aqueous solution into a beaker of 5mL 1g / mL tannic acid aqueous solution, stir well at 30°C, centrifuge, and pour out the upper layer solution , to obtain a soft tissue medical glue with anti-infection properties.

[0054] Fix the pigskin with a diameter of 6 mm on the cylindrical fixture of the universal ...

Embodiment 2

[0061] Add 5g of tannic acid and 5mL of ultrapure water to No. 1 beaker, and dissolve by ultrasonication at 30°C for 15 minutes to obtain 5mL of 1g / mL tannic acid aqueous solution; add 5g of polyetheramine and 5mL of ultrapure water to No. Dissolve to obtain 5 mL of 1 g / mL polyetheramine aqueous solution; add 0.05 g of gentamicin sulfate and 1 mL of ultrapure water to No. 3 beaker, and dissolve by ultrasonication at 30°C for 15 minutes to obtain 1 mL of 0.05 g / mL gentamicin sulfate aqueous solution.

[0062] Add 2.5mL of 1g / mL polyetheramine aqueous solution and 1mL of 0.05g / mL gentamycin sulfate aqueous solution into a beaker of 5mL of 1g / mL tannic acid aqueous solution, stir well at 30°C, centrifuge, pour out the upper layer solution, A soft tissue medical glue with anti-infection properties is obtained.

[0063] According to the method in Example 1, the present invention tested the cohesive force and cohesive strength of the anti-infective soft tissue medical glue obtained ...

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Abstract

The invention provides an anti-infection soft tissue medical glue and a preparation method thereof, which are prepared from plant polyphenols, water-soluble polymers, aminoglycoside antibiotics and solvents. Among them, the catechol unit in the plant polyphenol can be hydrogen-bonded with the electron-donating group in the water-soluble polymer and electrostatically combined with the protonated aminoglycoside antibiotic in the physiological environment to obtain an anti-infective soft tissue medical glue. Compared with the existing technology, the medical adhesive has higher cohesiveness, better biocompatibility, and better hemostatic performance, and the pH value is different according to the amount of bacteria adhered to different parts of the material, and the responsive release Antibiotics have good durability, avoiding the problems of drug resistance and gradual release of antibiotics caused by long-term exposure to antibiotics. The preparation method of the anti-infection soft tissue medical glue is simple, low in cost and suitable for large-scale production. Experimental results show that the soft tissue medical glue has a cohesive force of 5.09N and a cohesive strength of 180kPa.

Description

technical field [0001] The invention relates to the field of medical devices, in particular to an anti-infection soft tissue medical glue and a preparation method thereof. Background technique [0002] There are 26 million to 90 million cutting injuries and more than 7 million trauma ruptures every year. In surgical operations, antibacterial and hemostasis are the basis, and for the repair of biological tissues, suture and tie are two basic operations. However, this traditional method of stitching and pricking is not only cumbersome and laborious, but also easily causes bleeding and new damage, which brings more pain to the patient. At present, medical glue can be used to replace or partly replace thread suture. Compared with suture thread, medical glue has many advantages: it can effectively stop bleeding, isolate air, avoid the damage of acupuncture to human tissue, easy to use, reduce operation time, and do not need to be removed. . An ideal medical adhesive should meet...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/46A61L15/44A61L15/42
Inventor 栾世方王向红殷敬华施德安杜山山闫顺杰石恒冲
Owner CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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