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Compounds encapsulated nanoparticles and nanoemulsions preparation and use thereof

A nanoparticle and nanoemulsion technology, applied in nanotechnology, nanotechnology, nanomedicine, etc., can solve problems such as tasks that are difficult for single-layer nanoparticles to fine

Active Publication Date: 2016-01-27
杭州美依生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In order to pass through lipophilic and hydrophilic membranes more than once through these skin layers and cells in the skin, simple monolayer nanoparticles are difficult to accomplish this delicate task

Method used

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  • Compounds encapsulated nanoparticles and nanoemulsions preparation and use thereof
  • Compounds encapsulated nanoparticles and nanoemulsions preparation and use thereof
  • Compounds encapsulated nanoparticles and nanoemulsions preparation and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Example 1: A Surfactant System A (Caprylic Capric Glycerides, Oil A)

[0019] Caprylic capric glyceryl (2 g) was added to polyoxyethylene castor oil (3 g) and mixed well at room temperature. An aqueous solution of the active ingredient (0.25 g) such as hyaluronic acid (0.5%) is then added and mixed well. The resulting clear solution was measured for particle size and zeta potential using a Malvern particle size analyzer. The particle size (z average) by intensity is 12.52nm, and the particle size by volume distribution is from 4.63nm to 10.40nm (Chart 1). In a separate container, this clear solution was added to 45 grams of hyaluronic acid in water (0.5%), stirred and mixed well. The resulting material was a clear to light blue solution with a particle size (z-average) of 31.91 nm by intensity and a particle size distribution by volume ranging from 16.50 nm to 37.60 nm (Chart 2). To this nanoparticle solution was added a cream containing emulsifier PemulenTR2 (2 g)...

Embodiment 2

[0031] Example 2: A Surfactant System B (Medium Chain Triglycerides (Labrafac Lipophile WL1349), Oil B)

[0032] In a beaker, polyoxyethylene castor oil (3 grams) was added to medium chain triglycerides (Labrafac Lipophile WL1349 oil) (2 grams) at room temperature with stirring and mixed well. An aqueous solution (0.25 g) containing active ingredients such as hyaluronic acid (0.5%) is then added to the mixture and mixed well. The resulting clear solution was measured for particle size using a Malvern particle size analyzer. The size of the zeta potential is 13.54nm according to the intensity (Z-average), and 5.00nm to 11.20nm according to the volume distribution (Chart 4). In a separate container, this clear solution was added to 45 grams of hyaluronic acid solution (0.5%), stirred and mixed well. The resulting material was a clear to pale blue solution with a particle size (z-average) of 31.19 nm by intensity and a particle size of 16.60 nm to 37.50 nm by volume distribut...

Embodiment 3

[0042] Example 3: Two surfactant systems (polyoxyethylene castor oil and Tween 20)

[0043] In a beaker, polyoxyethylene castor oil (2.0 g) and polysorbate 20 (Tween-20, 1 g) were added to caprylic capric glyceride (2 g) and mixed well at room temperature. An aqueous solution containing the active ingredient such as hyaluronic acid (0.25 g) is added to the mixture and mixed well. The resulting clear solution was measured for particle size using a Malvern particle size analyzer. Its particle size by intensity (z-average) is 25.45 nm, and its particle size by volume distribution ranges from 6.82 nm to 16.80 nm (Chart 7). This clear solution was added to 45 grams of hyaluronic acid (0.5%) in water, stirred and mixed well. The resulting nanoemulsion is transparent and light blue. Its particle size by intensity (z-average) is 37.13 nm, and its particle size by volume distribution ranges from 19.20 nm to 44.00 nm (Chart 8). The formed nanoparticles were further stabilized by a...

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Abstract

The invention described herein is related to the preparation and usage of nanoemulsions and nanoparticles which containing biological active ingredients including cosmetic, medical and pharmaceutical active ingredients to pass skin barriers and promote cell growth with evident clinical effects. Also, the present invention contains a cosmetic formulation that can be used for skin rejuvenation, wrinkle removal, scar treatment and wounds healing.

Description

[0001] Related reference applications [0002] This PCT application claims the benefit of the filing date of U.S. Provisional Application No. 61 / 830,335, entitled "Preparation and Use of Compound-Coated Nanoparticles and Nanoemulsions," filed June 2013 3rd. The entire content of this referenced application is incorporated into this application by reference. technical field [0003] The present invention relates to the preparation and use of nanoemulsions and nanoparticles containing biologically active ingredients, including cosmetic, medical and pharmaceutical active ingredients that can pass through the skin barrier and promote cell growth and have obvious clinical effects. Background technique [0004] Nanomaterials refer to the manipulation of matter at the atomic or molecular level. A nanometer (nm) is one billionth of a meter, or 10 -9 Meter. By comparison, the classic carbon-carbon bond length, or the distance between atoms in a molecule, is between 0.12-0.15 nano...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/113A61K38/00A61K47/00B82Y5/00
CPCA61K8/066A61K8/4946A61K8/64A61K8/675A61K8/735A61K8/9789A61K8/9794A61K9/0014A61K9/1075A61K9/113A61K38/00A61K2800/21A61Q19/08B82Y5/00
Inventor 刘慧文张伯科
Owner 杭州美依生物科技有限公司
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