A method and medicine for inhibiting Echinococcus granulosus infection
A technology of Echinococcus granulosus and drugs, which is applied in the field of biology and medicine, can solve the problems of animal echinococcosis, which has no application value, is difficult to remove completely, and is at a loss.
Inactive Publication Date: 2018-07-31
陈雪玲
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Problems solved by technology
In clinical practice, the disadvantage of surgical treatment is that hydatid cysts are implanted due to cystic fluid overflow during surgery; at the same time, it is difficult to treat small hydatid cysts deep in the liver parenchyma, especially for the elderly, infirm or patients. For cases with important organ diseases, and for those with multiple echinococcosis and multiple organs involved, surgical operation is particularly difficult, especially the secondary cystic fluid exudation and implantation due to hepatic hydatid cyst rupture. For episodic abdominal echinococcosis, it is difficult to remove all of them even after multiple operations; for the extensively infiltrated multilocular hepatic echinococcosis, surgery is helpless
In particular, the existing treatment schemes for human echinococcosis are relatively expensive, and have no application value in the treatment of animal echinococcosis
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[0014] In order to illustrate the effect of the technical solution of the present invention, the applicant took a specific scientific research experiment as an example to conduct an experiment. Those skilled in the art should understand that the technical solution disclosed below is only a verification and description of the principle of the present invention, and does not limit the details of the technical solution of the present invention, such as various operating procedures, dosage, application methods, etc.
[0015] In the following experiments, the pathogen used was Echinococcus granulosus, which was collected and cultured with a vigor >90% for the experiment; the mice used were female BALB / c mice, 6-8 weeks old, with a body weight of 20±2g.
[0016] In the following, the relevant antibodies used can be purchased from reagent companies, such as anti-Fc antibodies, anti-Tim-3 antibodies, and anti-IgG antibodies sold by Ebioscience, and other antibody companies also sell si...
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The invention discloses a method for inhibiting echinococcus granulosus infection. The echinococcus granulosus infection is blocked with the use of an anti-Tim-3 antibody. According to the technical scheme disclosed by the invention, the phagocytic function of macrophages of an echinococcus granulosus infected object is directly enhanced by virtue of the anti-Tim-3 antibody, so that the immune capacity of the object to the echinococcus granulosus is improved.
Description
technical field [0001] The invention relates to a method for inhibiting echinococcus granulosus infection and a medicine for treating echinococcosis caused by echinococcus granulosus infection, belonging to the fields of biology and medicine. Background technique [0002] Echinococcus granulosus is a kind of zoonotic parasitic disease that seriously endangers health caused by the continuation stage larvae of Echinococcus granulosus parasitizing in human liver, lung and other organs. In my country, such diseases mainly include Cystic echinococcosis (CE) and alveolar echinococcosis (AE) are parasitized by the larvae of Echinococcus granulosus (Echinococcus) and Echinococcus multilocularis (Echinococcus), respectively. caused by the tissues and organs of the human body. Among the two, cystic echinococcosis, also known as echinococcosis granulosus, can form a cycle between animals or between humans and animals, and become a natural foci disease, which is an urgent need to control...
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IPC IPC(8): A61K39/395A61P33/10
Inventor 陈雪玲吴向未徐芳洁
Owner 陈雪玲