Blow-Fill-Seal Fully Automatic Aseptic Production Process for Water Needle Injection

Abstract

The invention discloses a full-automatic aseptic production technology for blowing, filling and sealing of a water needle injection medicament. The full-automatic aseptic production technology comprises the production technology steps that firstly, raw materials are sterilized; secondly, impurity removing is conducted on the raw materials; thirdly, material melting is conducted; fourthly, filling and forming are conducted; fifthly, die opening is conducted; sixthly, punching and slitting are conducted; and seventhly checking is conducted. The materials are sterilized and disinfected in the heating step and the material melting step in the production technology, and the use risk of the materials is lowered; during forming and filling, extruding, bottle blowing, local cooling, filling, sealing and die opening are conducted, blowing, filling and sealing are combined, the bottle forming time is short, pollution to liquid medicine from microorganisms and particles in air in a sealed environment is avoided, and especially the defect of a traditional mode is overcome through the ultra-low-temperature filling technology. Meanwhile, aseptic air is used in the whole process, pollution of microorganisms in air is effectively avoided, and medicine quality is ensured greatly.

Description

technical field [0001] The invention belongs to the field of production of plastic ampoule water needle injection medicaments, and in particular relates to a fully automatic aseptic production process of water needle injection medicament blowing, filling and sealing. Background technique [0002] Ampoule bottle is a small glass container used to hold medicinal liquid, generally with a capacity of 1-25ml. It is often used for injection medicinal liquid and also for the packaging of oral liquid. At present, low borosilicate glass ampoules are commonly used in our country, but glass ampoules have the following defects: [0003] 1. The inside of the glass ampoule is usually under negative pressure. When it is broken and opened, airborne microorganisms such as bacteria in the air are easily mixed in to contaminate the liquid medicine, causing bacteremia and toxic shock. At the same time, glass shards and glass dust generated during opening can enter the patient's body through th...

AI Technical Summary

Problems solved by technology

[0010] The invention provides a fully automatic aseptic production process of water needle injection medicament blowing, filling and sealing, which is used to solve the technical problems of low production efficiency, easy pollution in the production process, poor product adaptability, strong selectivity to drugs, and poor application effect in the prior art.

Images