Application of ciclopirox olamine in preparation of medicine for treating or preventing epilepsy

A technology for ciclopiroxamide and a drug, which is applied in the field of medicine, can solve the problems of no known antiepileptic activity and antiepileptic target activity of ciclopiroxamide, and achieves good antiepileptic efficacy, a simple method, and a reduction in rapid movement distance. Effect

Active Publication Date: 2016-02-24
HANGZHOU LEISUO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] So far, there are no relevant reports on the antiepilept

Method used

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  • Application of ciclopirox olamine in preparation of medicine for treating or preventing epilepsy
  • Application of ciclopirox olamine in preparation of medicine for treating or preventing epilepsy
  • Application of ciclopirox olamine in preparation of medicine for treating or preventing epilepsy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Embodiment one Quantitative observation of the efficacy of a single concentration of ciclopiroxamide in a zebrafish epilepsy model

[0019] Zebrafish:

[0020] The zebrafish used in this example is wild-type zebrafish, and the breeding and use standards are strictly in accordance with the requirements of the American Laboratory Animal Care and Use Committee (IACUC).

[0021] Fishwater:

[0022] Configuration method: Add 0.3g of sea salt (InstantOceansalts) to 1L of reverse osmosis (RO) water.

[0023] Dimethyl sulfoxide (DMSO, analytically pure):

[0024] Purchased from Aladdin (Catalog #1095515, Lot #30573). 1% DMSO solution (negative control) preparation: When in use, prepare a working solution with a concentration of 1.0% with fish farming water, and prepare it immediately for use.

[0025] PTZ (pentylenetetrazole, inducer):

[0026] Purchased from Sigma Company of the United States, batch number 069K1245. When in use, use 0.1% DMSO solution to prepare the co...

Embodiment 2

[0043] Embodiment two Multi-concentration verification of efficacy and safety of ciclopiroxamide in zebrafish epilepsy model

[0044] Experimental materials and experimental methods are the same as in Example 1. The total movement distance was analyzed by software to investigate the effects of 10, 30 and 100 μM concentrations of ciclopiroxamide on normal zebrafish movement. And in the PTZ-induced epilepsy model, investigate the effect of 10, 30, and 100 μM concentrations of ciclopiroxamide on the rapid movement distance of zebrafish, and judge whether it has antiepileptic drug effect.

[0045] see results image 3 , 4 , 5. Ciclopiroxamide inhibited the total movement distance of normal zebrafish by 25%, 13%, and 35% at concentrations of 10, 30, and 100 μM, respectively (p<0.01). At the same time, the state of the fish was observed under a dissecting microscope. The touch response basically disappeared, and the touch response in the 30μM and 10μM groups was normal. The re...

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Abstract

The invention belongs to the field of medical technology and specifically relates to an application of ciclopirox olamine in the preparation of a medicine for treating or preventing epilepsy. A compound is screened through a pentylenetetrazol (PTZ) induced zebra fish epilepsy model. Ciclopirox olamine can significantly reduce rapid movement distance (V is greater than 20 mm/sec) of epilepsy zebra fish but doesn't affect total movement distance. It explains that at atoxic concentration, ciclopirox olamine shows good efficacy in curing or preventing epilepsy.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of ciclopiroxamide in the preparation of drugs for treating or preventing epilepsy. Background technique [0002] Epilepsy is a chronic recurrent short-term brain dysfunction syndrome characterized by repeated epileptic seizures caused by abnormal discharge of brain neurons. Seizures can manifest as motor, sensory, conscious, mental, behavioral, and autonomic dysfunction. Epilepsy is one of the common diseases of nervous system, with about 50 million patients worldwide, and the incidence rate is about 1%. Epilepsy can occur at any age, regardless of gender or socioeconomic status. The mortality rate of epilepsy is about 20%, which causes a great burden to the family and society. At present, after the existing antiepileptic drug treatment, there are still about 30% of patients whose drug resistance cannot be controlled [1]. Epilepsy that cannot be controlled b...

Claims

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Application Information

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IPC IPC(8): A61K31/4412A61P25/08
Inventor 李春启周娟宋如顺郭胜亚高羽军吴耀东
Owner HANGZHOU LEISUO PHARMA
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