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Mono-cyclohexyl fumarate preparation method

A technology of monocyclohexyl fumarate and cyclohexyl fumarate, which is applied in the field of preparation of monocyclohexyl fumarate, can solve the problems of high irritation, easy sublimation, unsuitability, etc., and achieves a product with strong practical operability and simple preparation method Effect

Inactive Publication Date: 2016-02-24
SHAANXI HUANKE BIOLOGICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Dimethyl fumarate was once considered to be the most promising chemical preservative, but it is easy to sublimate and irritating, so it is not suitable for use as a food preservative. Therefore, researchers turned to the development of other preservatives based on fumaric acid. agent

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0006] Include the following steps:

[0007] (1) Add cyclohexanol to maleic anhydride, heat and stir until all maleic anhydride solids are dissolved, (2) Add S0 4 2- / SnO 2 -A1 2 o 3 Catalyst, react in the state of slight boiling reflux for 5 hours; (3) After the reaction, take an appropriate amount of absolute ethanol and add it to the three-necked flask, and filter and recover the catalyst while keeping the solution hot, (4) Let the filtrate stand and cool until the white solid precipitates; ( 5) Filter and dry the precipitated white solid to obtain the white monocyclohexyl fumarate product.

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PUM

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Abstract

The invention relates to a mono-cyclohexyl fumarate preparation method. The method comprises that 1, cyclohexanol is added into maleic anhydride, and the mixture is heated and stirred until maleic anhydride solids are completely dissolved, 2, a SO4<2-> / SnO2-Al2O3 catalyst is added into the solution and the mixed solution undergoes a reaction in a slight boiling reflux state for 5h, 3, after the reaction, a proper amount of anhydrous ethanol is taken and is added into a three-mouth flask, and the catalyst is filtered and recovered in a hot solution state, 4, the filtrate is stood and cooled until white solids are separated, and 5, the white solids are filtered and dried so that the white mono-cyclohexyl fumarate product is obtained. The mono-cyclohexyl fumarate preparation method has simple processes and good practicability and operationality.

Description

technical field [0001] The invention relates to a preparation method of monocyclohexyl fumarate. Background technique [0002] Fumarate has an α, β-unsaturated carbonyl structure, so it has good antibacterial activity. As a preservative, it has the advantages of low toxicity, high efficiency, and no residue. Dimethyl fumarate was once considered to be the most promising chemical preservative, but it is easy to sublimate and irritating, so it is not suitable for use as a food preservative. Therefore, researchers turned to the development of other preservatives based on fumaric acid. agent. Fumaric acid monoesters are favored as a class of important organic synthesis intermediates and new chemical preservatives. As a preservative, monocyclohexyl fumarate has the advantages of high efficiency, high temperature resistance, and low irritation, and overcomes the obstacles encountered in the application of dimethyl fumarate, so it has a wide range of applications in the fields of...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C69/60C07C67/08
CPCC07C67/08
Inventor 郝青
Owner SHAANXI HUANKE BIOLOGICAL TECH CO LTD