Xiaokening tablet and preparation method thereof
A technology for Ning tablets and bronchial asthma, applied in the field of Xiaoke Ning tablets and its preparation, can solve the problems of slow disintegration, unsatisfactory curative effect, and low curative effect
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Embodiment 1
[0023] Take 35g of patchouli, 17.5g of pomegranate peel, 95g of licorice, 5g of bitter almond, and 20g of calcium carbonate, grind them into a 60-mesh coarse powder, and use carbon dioxide supercritical extraction method to extract, the extraction pressure is 30Mpa, the extraction temperature is 30°C, and the separator pressure is 10Mpa , the temperature of the separator is 50°C, the separation time is 2 hours, the flow rate of carbon dioxide is 40L per hour, and the extract is obtained; the extract is dried under reduced pressure at 60°C to obtain a dry paste; the dry paste is added with 150g of calcium sulfate, and crushed into Mixed dry paste powder with a particle size of 200-300nm; take the mixed dry paste powder, 45g of microcrystalline cellulose, 45g of cross-linked polyvinylpyrrolidone, 35g of cross-linked carmellose sodium, mix well, and wet granulate with 50% ethanol , dried at 60°C, added 7 g of sodium carboxymethyl starch, 1 g of magnesium stearate, granulated, and ...
specific Embodiment 2
[0025] Take 35g of patchouli, 17.5g of pomegranate peel, 95g of licorice, 5g of bitter almond, and 20g of calcium carbonate, grind them into a 60-mesh coarse powder, and use carbon dioxide supercritical extraction method to extract, the extraction pressure is 40Mpa, the extraction temperature is 40°C, and the separator pressure is 20Mpa , the temperature of the separator is 60°C, the separation time is 4 hours, the flow rate of carbon dioxide is 50L per hour, and the extract is obtained; the extract is dried under reduced pressure at 80°C to obtain a dry paste; the dry paste is added with 200g of calcium sulfate, and crushed into Mixed dry paste powder with a particle size of 200-300nm; take the mixed dry paste powder, 55g of microcrystalline cellulose, 55g of cross-linked polyvinylpyrrolidone, 45g of cross-linked carmellose sodium, mix well, and wet granulate with 70% ethanol , dried at 80°C, added 9 g of sodium carboxymethyl starch, 3 g of magnesium stearate, granulated, and ...
Embodiment 3
[0027] Take 35g of patchouli, 17.5g of pomegranate peel, 95g of licorice, 5g of bitter almond, and 20g of calcium carbonate, grind them into a 60-mesh coarse powder, and use carbon dioxide supercritical extraction method to extract, the extraction pressure is 35Mpa, the extraction temperature is 35°C, and the separator pressure is 15Mpa , the temperature of the separator is 55°C, the separation time is 3 hours, and the flow rate of carbon dioxide is 45L per hour to obtain the extract; take the extract and dry it under reduced pressure at 70°C to obtain a dry paste; add 175g of calcium sulfate to the dry paste, and grind it into Mixed dry paste powder with a particle size of 200-300nm; take the mixed dry paste powder, microcrystalline cellulose 50g, cross-linked polyvinylpyrrolidone 50g, cross-linked carmellose sodium 40g, mix well, and wet granulate with 60% ethanol , dried at 70°C, added 8 g of sodium carboxymethyl starch, 2 g of magnesium stearate, granulated, and compressed ...
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