Cerebral edema treating pharmaceutical composition and uses thereof

A composition and brain edema technology, applied in the field of medicine, can solve problems such as pain, injection site irritation, lack of consensus, etc., and achieve the effect of reducing damage, reducing dosage, and consolidating the therapeutic effect

Active Publication Date: 2016-03-16
SHANDONG LUOXIN PARMACEUTICAL GROUP STOCK CO LTD
View PDF3 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] 3) Drugs such as hormones are used to damage brain cells, and there is still no unified opinion on the application of large doses of hormones
However, when the dosage of piracetam is high, it can cause local irritation and pain at the injection site

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Cerebral edema treating pharmaceutical composition and uses thereof
  • Cerebral edema treating pharmaceutical composition and uses thereof
  • Cerebral edema treating pharmaceutical composition and uses thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] The preparation of embodiment 1 compound tablet

[0028]

[0029] Preparation process: mix oxiracetam and ethacrylic acid with auxiliary materials microcrystalline cellulose and starch evenly, add an appropriate amount of 15% starch to make soft material, and pass through a 16-mesh sieve to granulate. The wet granules are dried at 60°C, the dry granules are sieved through a 16-mesh sieve for granulation, added with sodium carboxymethyl starch and magnesium stearate, mixed evenly, and pressed into tablets to obtain the product.

Embodiment 2

[0030] The preparation of embodiment 2 compound tablet

[0031]

[0032]

[0033] Preparation process: mix oxiracetam and ethacrynic acid with auxiliary materials lactose and compressible starch evenly, add appropriate amount of 15% starch slurry to make soft material, and then granulate through a 16-mesh sieve. The wet granules are dried at 60°C, the dry granules are sieved through a 16-mesh sieve for granulation, added with croscarmellose sodium and micropowder silica gel, mixed evenly, and pressed into tablets to obtain the product.

Embodiment 3

[0034] The preparation of embodiment 3 compound dispersible tablets

[0035]

[0036] Preparation process: Weigh oxiracetam and ethacrynic acid according to the prescription, use microcrystalline cellulose as filler, cross-linked sodium carboxymethyl cellulose and cross-linked polyvinylpyrrolidone as disintegrants, 5% PVP k30 60% ethanol solution is used as binder, micronized silica gel is used as flow aid, granulated in one step in a fluidized bed, then added with magnesium stearate, mixed evenly, and pressed into tablets to obtain the product.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The present invention belongs to the field of medicine, and relates to a cerebral edema treating pharmaceutical composition and uses thereof. A purpose of the present invention is to solve the technical problems of inexact treatment effect and high drug adverse reaction in the prior art. The present invention provides a cerebral edema prevention and treatment pharmaceutical composition, which comprises ethacrynic acid and oxiracetam, and provides good treatment effects for cerebral edema after brain trauma, cerebral hemorrhage, cerebral infarction, meningitis, brain tumors and other brain injuries and cerebral surgeries. Compared with the drug in the prior art, the pharmaceutical composition of the present invention has advantages of exact treatment effect, low adverse reaction, and good medical application prospects.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to a pharmaceutical composition for treating cerebral edema and its application. Background technique [0002] Cerebral edema refers to the pathological phenomenon that the increase of water in the brain leads to the increase of brain volume, and it is the response of brain tissue to various pathogenic factors. It can cause intracranial hypertension and damage brain tissue. Clinically, it is common in neurological diseases, such as craniocerebral trauma, intracranial infection (encephalitis, meningitis, etc.), cerebrovascular disease, intracranial space-occupying disease (such as tumor), Seizures and systemic diseases such as toxic dysentery and severe pneumonia. The pathogenesis of cerebral edema is very complicated, and there are many related factors, such as blood-brain barrier, microcirculation disorder, cerebral ischemia and hypoxia, increase of free radicals in the brain, changes of thr...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4015A61P25/00A61P7/10A61K31/192
Inventor 韩风生侯善波李晓峰
Owner SHANDONG LUOXIN PARMACEUTICAL GROUP STOCK CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap