Polycaprolactone and silk fibroin electrospun fibrous membrane with surface of continuous laminated micro-nano structure and preparation method and application thereof

A micro-nano structure, polycaprolactone technology, applied in the field of nanomaterials, can solve the problems of biomedical application obstacles, poor mechanical properties and degradation ability, etc., to increase the possibility of changing from hydrophobicity to hydrophilicity, improve fiber Effect of surface area, fiber diameter increase

CN105421058AInactive Publication Date: 2016-03-23KUNMING MEDICAL UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Publication Date
2016-03-23
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a polycaprolactone and silk fibroin electrospun fibrous membrane with the surface of a continuous laminated micro-nano structure and a preparation method and application thereof. The preparation method comprises the steps that 1, silk fibroin and polycaprolactone are dissolved into hexafluoroisopropanol and are stirred and dissolved at room temperature to obtain a mixed solution; 2, electrostatic spinning is performed on the mixed solution to prepare a polycaprolactone and silk fibroin blended membrane; 3, vacuum drying is performed on the polycaprolactone and silk fibroin blended membrane, then, the polycaprolactone and silk fibroin blended membrane is subjected to a heating reaction with a PCL monomer and a stannous octoate catalyst under the nitrogen protection, and the polycaprolactone and silk fibroin electrospun fibrous membrane is obtained. The polycaprolactone and silk fibroin electrospun fibrous membrane obtained through the preparation method has the surface layer laminated micro-nano structure fiber morphology, the specific surface area and the fiber diameter are greatly increased, the probability that the hydrophobicity of the electrospun membrane is converted into hydrophile is increased, the fiber specific surface area is greatly increased, and the space maintaining capacity, the dynamic mechanics performance and the degradation performance are greatly improved.
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Description

technical field

[0001] The invention belongs to the technical field of nanometer materials, and in particular relates to a polycaprolactone silk fibroin electrospun fiber membrane with a continuous lamellar micro-nano structure on the surface, a preparation method and application thereof. Background technique

[0002] After realizing the importance of guided tissue regeneration membrane technology, polytetrafluoroethylene membrane (ePTFE) was first used in the research field of guided bone regeneration, but there were a series of complications during the use of ePTFE membrane, and a second operation was required to remove it . The absorbable membrane can control the degradation rate, without the need for secondary surgery to remove it, which is convenient for the operator to operate, reduces the pain of the patient, shortens the healing period, and reduces complications such as membrane exposure and infection. A large number of animal experiments have studied the applicatio...

Examples

Embodiment

[0036] Step (1) Put the natural silk in a sodium bicarbonate (0.5wt%) aqueous solution and boil it for 30 minutes, take it out, rinse it with deionized water for 3 times, and repeat the above steps 3 times. Place the degummed silk in a vacuum drying oven at 40°C for 48 hours in vacuum;

[0037] Dissolve 0.3 g of silk and 0.7 g of polycaprolactone particles in 10 ml of hexafluoroisopropanol solvent, and stir at a constant speed for 6 hours at room temperature until the silk and polycaprolactone are completely dissolved to obtain a mixed solution;

[0038] Step (2) Put the mixed solution in a 20ml syringe, exhaust the air, fix it on a dual-channel micro-syringe pump, set the rate at 2.0ml / h, connect the metal needle of the syringe to a high-voltage electrostatic field, and perform electrospinning at room temperature. Electrospinning parameters are: spinning distance 15-20cm; spinning voltage 18-20kV; booster pump flow rate 1.8-2.2ml / h, electrospinning the mixed solution at room ...