Macitentan crystal form and preparation method thereof
A technology of macitentan and its crystal form, which is applied in the field of drug synthesis, can solve problems such as unreported information on the crystal form of macitentan, and achieve the effects of easy production and storage, good stability of the crystal form, and simple operation
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Embodiment 1
[0060] Dissolve 1 g of macitentan crude product in 10 ml of methanol, heat until dissolved, slowly cool down to 20-25°C, keep warm for 2 hours, then slowly cool down to 0-5°C, keep warm for 2 hours, filter, and dry to obtain the present invention The crystal form sample of macitentan is 0.82g.
Embodiment 2
[0062] Dissolve 1 g of macitentan crude product in 50 ml of ethanol, heat until dissolved, slowly cool down to 20-25°C, keep warm for 3 hours, then slowly cool down to 0-5°C, keep warm for 3 hours, filter, and dry to obtain the present invention The crystal form sample of macitentan is 0.78g.
Embodiment 3
[0064] Dissolve 1 g of macitentan crude product in 70 ml of isopropanol, heat until dissolved, slowly cool down to 20-25°C, keep warm for 2 hours, then slowly cool down to 0-5°C, keep warm for 3 hours, filter, and dry to obtain The crystalline form sample of macitentan described in the present invention is 0.82g.
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