Medicinal composition for treating lacunar infarction and preparation method of medicinal composition

A composition and technology of cerebral infarction, applied in the direction of drug combination, pharmaceutical formula, medical preparations containing active ingredients, etc., can solve problems such as slurred speech, slow speech, unfavorable treatment, etc., and achieve short treatment period and improved Microcirculation, the effect of relieving cerebral edema

Inactive Publication Date: 2016-05-04
济南思拓新源医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

2. Simple dysarthria type: All have mild language impairment, manifested as ambiguous speech, inaccurate pronunciation and intonation, but no phonemic errors, and can be completely understood. Some patients have poor sense of sound and slow speech
6. Vascular dilation: It is generally believed that the effect of vasodilators is uncertain. For severe patients with increased intracranial pressure, sometimes it can aggravate the condition, so it is not recommended to use it in the early stage
While treating cerebral infarction, western medicine has certain side effects on the liver, kidney, digestive tract and nervous system;

Method used

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  • Medicinal composition for treating lacunar infarction and preparation method of medicinal composition
  • Medicinal composition for treating lacunar infarction and preparation method of medicinal composition

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preparation example Construction

[0074] When the dosage form of the pharmaceutical composition is a capsule, its preparation method comprises the following steps:

[0075] The first step is to mix the raw medicinal materials in proportion, add ethanol with an alcohol concentration of 85-95% relative to the mass of the mixture 2-4 times, heat and reflux for 1-3 hours, extract, and filter to obtain the first extract; filter The obtained dregs are then added with ethanol with an alcohol concentration of 85-95% which is 1-2 times the mass of the dregs, heated and refluxed for 1-3 hours, extracted, filtered to obtain a second extract; the first extract and The second extracts were combined, concentrated under reduced pressure to remove the ethanol solvent, and dried to obtain a dry paste;

[0076] In the second step, the dry paste obtained in the first step is placed in an ultrafine pulverizer for 1 to 2 hours, pulverized, and sieved to obtain an ultrafine powder of 300 mesh to 400 mesh;

[0077] In the third ste...

Embodiment 1

[0090] Embodiment 1 capsule

[0091] The manufacture process of the capsule of the present invention is: get Hypericum perforatum 280g, Grub 320g, Geli juice 200g, Magnolia officinalis 150g, Sawgrass 140g, Dandelion 330g, Iron vine root 260g, Citrus aurantium 170g, Purple ginseng 150g, hanging candle 350g, 240g chicory, 180g tiger tail wheel, 150g white weed, 300g fence net, 30g small copper hammer, 250g cotton notoginseng, 300g aster, 220g fiddle leaf banyan, 180g curcuma, 140g horizontal sutra mat, 300g gardenia, tung tree root 40g, 210g of Mangosteen, 320g of False Betel Leaf and 200g of Sagittarius;

[0092] The first step is to mix the raw medicinal materials in proportion, add ethanol with an alcohol concentration of 90% that is three times the mass of the mixture, heat and reflux for 2 hours, extract, and filter to obtain the first extract; Ethanol with an alcohol concentration of 95% that is 1.5 times the mass of the medicinal residues is heated to reflux for 2 hours,...

Embodiment 2

[0095] Embodiment 2 oral liquid

[0096] The preparation process of the oral liquid of the present invention is as follows: get Hypericum perforatum 150g, Grub 200g, Geli juice 180g, Magnolia officinalis 250g, Sawgrass 140g, Dandelion 350g, Iron vine root 230g, Citrus aurantii 170g, Purple ginseng 150g, hanging candle 320g, 240g chicory, 300g tiger tail wheel, 170g white weed, 240g fence net, 20g small copper hammer, 170g cotton notoginseng, 310g aster, 220g fiddle leaf banyan, 340g curcuma, 200g horizontal sutra mat, 260g gardenia, tung tree root 30g, 250g of cloverleaf, 400g of betel leaves and 160g of sage vine;

[0097] In the first step, mix chicory, tiger tail wheel, Baiwei, fence net, small copper hammer and cotton notoginseng, add 60% ethanol with an alcohol concentration 4 times that of the mixture, and reflux extraction for 3 times, each time for 2.5 hours, Filtrate, combine the filtrates, recover ethanol, concentrate to a paste with a relative density of 1.31 at 70...

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Abstract

The invention discloses a medicinal composition for treating lacunar infarction and a preparation method of the medicinal composition. The medicinal composition is prepared from the following raw material medicines: hyperforin perforatum, longicorn's larva, oriental grape juice, mangnolia officinalis flowers, sawgrass, dandelion, root of schoch craspedolobium, immature bitter orange, salvia chinensis, wrightia pubescens, cichorium intybus, uraria crinite, blackend swallowwort roots, merremia hederacea, spilanthes callimorpha, eriosema himalaicum, aster tataricus, ficus lyrata, curcuma zedoary, membranaceous beautyleaf root, jasmine, vernicia fordii, elaeagnus glabra, piper sarmentosum, sargentgloryvine stem as well as long stephania herb, water chestnut, walton's lepisorus, wild chervil, stellaria dichotoma and seseli giraldii. The medicinal composition has the beneficial effects of promoting circulation and removing stasis, inducing resuscitation with herbal aromatics, dredging the channels, relieving encephaledema and improving micro circulation, and has the advantages of rapid effect taking, high effective rate, definite treatment effect, short treatment course, effect-enhancing and toxicity-reducing, multiple target point treatment, low price, and the like.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a pharmaceutical composition for treating lacunar infarction and a preparation method thereof. Background technique [0002] Lacunar infarction is a relatively common type of cerebral infarction, accounting for about 20% of cerebral infarction. Completely different from atherosclerotic cerebral thrombosis, lacunar infarction mainly occurs in the deep penetrating branches of the anterior, middle, and posterior cerebral arteries and vertebral-basilar arteries and their branches, mainly caused by hypertension and its accompanying Caused by arteriolar hyaline degeneration or arterial embolism, the symptoms are relatively simple. It mostly occurs in the middle-aged and elderly people aged 40-60 and above, more men than women, the risk of lacunar infarction increases 8 times in hypertensive patients, and increases 5.6 times in smokers. Diabetic patients increase...

Claims

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Application Information

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IPC IPC(8): A61K36/9066A61P9/10A61K35/64
CPCA61K36/185A61K9/0095A61K9/19A61K9/485A61K36/24A61K36/27A61K36/28A61K36/288A61K36/39A61K36/47A61K36/48A61K36/53A61K36/575A61K36/60A61K36/67A61K36/744A61K36/752A61K36/80A61K36/9066A61K2236/333A61K2236/39A61K2236/51A61K2236/53A61K2300/00
Inventor 刘广义
Owner 济南思拓新源医药科技有限公司
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