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Field-assisted extraction-separation enrichment-chromatographic analysis online combined equipment

A technology of separation, enrichment and chromatographic analysis, applied in the field of on-site auxiliary extraction-separation and enrichment-chromatography online equipment, can solve the problems of lagging development of pre-treatment technology, affecting the sensitivity and reproducibility of analysis methods, etc., and improve the extraction efficiency and analysis sensitivity, and the effect of improving extraction efficiency

Active Publication Date: 2018-08-14
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

On the other hand, the extraction, enrichment / purification, and analysis of most current sample pretreatment technologies are relatively independent, and the complete sample pretreatment process often includes multiple offline steps. The error affects the sensitivity and reproducibility of the analytical method, etc.
Although the micro-extraction medium and micro-extraction technology in the pretreatment of gas samples and liquid samples and the online combination technology of these pretreatment methods and various analytical instruments have developed rapidly, the solid sample pretreatment technology and devices, especially fast, convenient and efficient The development of online solid sample pretreatment technology lags behind

Method used

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  • Field-assisted extraction-separation enrichment-chromatographic analysis online combined equipment

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Embodiment 1

[0046] In this embodiment, a field-assisted extraction-separation-enrichment-chromatographic analysis on-line combined device is used to analyze the PAHs in baked potatoes.

[0047] The specific operation is: Fill the extraction bottle 107 with anhydrous sodium sulfate, Flori silica and baked potato samples in sequence, and lightly compact them. After adding the extraction solvent 102 and the magnetic stirrer 101 into the receiving container 103, the ultrasonic probe 109 is extended into the solid phase adsorbent Florisil, and then the cooperative field auxiliary extraction unit is placed in the microwave-assisted extraction instrument 115, Set the extraction parameters and start the extraction.

[0048] When the extraction is finished, switch the first six-way switching valve 8 to the injection mode, and switch the second six-way switching valve to the load mode. The first high-pressure liquid phase pump 3 and the second high-pressure liquid phase pump 5 push the sample-loading s...

Embodiment 2

[0052] In this embodiment, a field-assisted extraction-separation-enrichment-chromatographic analysis online combined device is used to analyze polycyclic aromatic hydrocarbons in grilled fish.

[0053] The specific operation is as follows: Fill the extraction bottle 107 with anhydrous sodium sulfate, Flori silica and grilled fish samples in sequence, and lightly compact them. Add the extraction solvent 102 ethanol into the receiving container 103, put in the magnetic stirrer 101, extend the ultrasonic probe 109 into the solid phase adsorbent, then place the cooperative field auxiliary extraction unit in the microwave auxiliary extraction instrument 115, and set the microwave power 300W, ultrasonic power 100W, extraction time 15min, extraction temperature 73℃, rotation speed 1000rpm. Start the extraction.

[0054] When the extraction is finished, switch the first six-way switching valve 8 to the injection mode, and switch the second six-way switching valve to the load mode. The f...

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Abstract

The invention discloses FAE-separation and enrichment-chromatographic analysis on-line combination equipment which comprises four high pressure liquid phase pumps, two six-port switch valves, a collaborative auxiliary extraction unit, an on-line filter, a solid phase extraction column, a chromatographic column, a detector and the like, a collaborative FAE device, an on-line separation and enrichment port and an efficient liquid chromatography device are combined, and field effect advantages of a thermal field, an ultrasonic field and a microwave field are combined, so that synergistic extraction with various filed effects is realized, and the extraction efficiency is improved. Sample extraction, on-line enrichment and chromatography rapid separation analysis are integrated, sample loss caused by off-line extraction and separation and enrichment is effectively avoided, the extraction efficiency and the analysis sensitivity are improved, and the equipment can be effectively used for analysis and detection of complex samples.

Description

Technical field [0001] The invention belongs to the field of analytical chemical sample pretreatment, and specifically relates to a field-assisted extraction-separation enrichment-chromatography on-line combined equipment, which is suitable for online sample pretreatment, separation and enrichment of trace analytes in complex matrices such as food and biology. Chromatographic analysis and detection. Background technique [0002] For solid or semi-solid samples, it is first necessary to efficiently and quickly transfer the analyte from the solid matrix to the corresponding extraction solvent before further separation, enrichment, analysis and detection can be carried out. By introducing appropriate external forces such as field effects to increase the energy of the separation system or reduce the entropy of the system, the relative migration and material balance between the analyte and the extraction solvent in the sample can be promoted, thereby improving the efficiency of sample...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/88
CPCG01N30/08G01N30/88G01N2030/8809
Inventor 肖小华李攻科何园缘
Owner SUN YAT SEN UNIV