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Trimetazidine sustained-release mini-pill composition and method for preparing same

A technology of trimetazidine and sustained-release pellets, applied in the field of drug research and development, can solve the problems of difficulty in long-acting sustained release and difficulty in reaching zero-order release standards, etc.

Active Publication Date: 2016-06-01
南京卓康医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] The purpose of the present invention is to provide a trimetazidine pharmaceutical composition, which mainly solves the problems that the existing trimetazidine drugs are difficult to carry out long-acting sustained release and difficult to reach the zero-order release standard

Method used

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  • Trimetazidine sustained-release mini-pill composition and method for preparing same
  • Trimetazidine sustained-release mini-pill composition and method for preparing same
  • Trimetazidine sustained-release mini-pill composition and method for preparing same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Sustained-release pill A:

[0038]

[0039] Sustained-release pill B:

[0040]

[0041] Sustained release pill C:

[0042]

[0043] (1) Prepare the trimetazidine raw material drug, adhesive, anti-adhesive agent and water in the above-mentioned prescription amount to make a liquid medicine, and then dry the medicine on a fluidized bed of the ball core to prepare a pill containing the medicine;

[0044] (2) Prepare the above prescription amount of slow-release material, anti-adhesive agent, plasticizer and ethanol to make a coating solution, then fluidize the pills obtained in step (1) and dry them in sequence to prepare different Three sustained-release pills A, B and C for weight gain;

[0045] (3) Mix the sustained-release pill A, sustained-release pill B, and sustained-release pill C according to the ratio of 53.1% by weight: 26.2% by weight: 20.6% by weight, fill capsules with 100% of the marked amount, and obtain trimetazidine sustained-release capsule.

Embodiment 2

[0047] Sustained-release pill A:

[0048]

[0049] Sustained-release pill B:

[0050]

[0051] Sustained release pill C:

[0052]

[0053] (1) The trimetazidine raw material drug in the above-mentioned prescribed amount, adhesive and anti-adhesive agent are prepared into a liquid medicine, the pill core is fluidized bed, dried, and the pill containing the medicine is prepared;

[0054] (2) Prepare the above prescription amount of slow-release material, anti-adhesive agent, plasticizer and ethanol to make a coating solution, then fluidize the pills obtained in step (1) and dry them in sequence to prepare different Three ER pills A, B and C for weight gain.

[0055] (3) Mix the sustained-release pill A, sustained-release pill B, and sustained-release pill C according to the ratio of 47.1% by weight: 28.0% by weight: 24.8% by weight, and fill the capsules with 100% of the marked amount to obtain trimetazidine sustained-release capsule.

Embodiment 3

[0057] Sustained-release pill A:

[0058]

[0059] Sustained release pill C:

[0060]

[0061] (1) The trimetazidine raw material drug in the above-mentioned prescribed amount, adhesive, anti-adhesive agent and water are prepared into a liquid medicine, the pill core is fluidized bed, dried, and the pill containing the medicine is prepared;

[0062] (2) Prepare the above prescription amount of slow-release material, anti-adhesive agent, plasticizer and ethanol to make a coating solution, then fluidize the pills obtained in step (1) and dry them in sequence to prepare different Two slow-release pills A and C for weight gain.

[0063] (3) Mix Sustained Release Pill A and Sustained Release Pill C at a ratio of 82.3% by weight: 17.7% by weight, fill capsules with 100% of the marked amount, and obtain trimetazidine sustained-release capsules.

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Abstract

The invention discloses a trimetazidine sustained-release mini-pill composition. The trimetazidine sustained-release mini-pill composition comprises sustained-release pills A and C or sustained-release pills A, B and C. The sustained-release pills A, B and C have different increased weights. The trimetazidine sustained-release mini-pill composition has the advantages that two or three types of film-controlled sustained-release mini-pills with different increased weights are proportionally mixed with one another to obtain the trimetazidine sustained-release mini-pill composition, accordingly, zero-order release effects can be realized by the trimetazidine sustained-release mini-pill composition, and the trimetazidine sustained-release mini-pill composition can be released in a long-acting and sustained manner.

Description

technical field [0001] The invention relates to the technical field of drug research and development, in particular to a trimetazidine sustained-release pellet composition and a preparation method thereof, and a trimetazidine sustained-release pellet containing the trimetazidine sustained-release pellet composition capsule. Background technique [0002] The chemical name of Trimetazidine is 1-(2,3,4-trimethoxybenzyl)piperazine, which is the first 3-ketoacyl-CoA thiolase inhibitor (3-KAT). It can inhibit the oxidation of fatty acid (FFA), stimulate the oxidation of glucose, and have a protective effect against myocardial ischemic cells to a certain extent. In recent years, trimetazidine hydrochloride has been widely used in the preventive treatment of angina pectoris and the auxiliary symptomatic treatment of vertigo and tinnitus. [0003] Trimetazidine is absorbed rapidly after oral administration, and its half-life is relatively short [t1 / 2=(6.0±1.4)h]. The concentration ...

Claims

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Application Information

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IPC IPC(8): A61K9/16A61K31/495A61K9/60A61P9/10A61P1/08A61P27/16
CPCA61K9/5078A61K9/5084A61K31/495
Inventor 刘伟张夕瑶李强
Owner 南京卓康医药科技有限公司
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