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Sustained release cubic liquid crystal liquid hard capsule and preparation method thereof

A liquid hard capsule and cube technology, which is applied in the field of sustained release, can solve the problems of difficulty in industrialized production of cubic liquid crystal oral preparations, corrosion of the soft capsule wall, and decreased stability of preparations, etc. Drug stability, storage and packaging benefits

Active Publication Date: 2018-12-11
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Organic solvents are highly irritating to the human gastrointestinal tract and have a corrosive effect on the soft capsule wall, which reduces the stability of the preparation and is prone to pouring
Therefore, the industrialized production of cubic liquid crystal oral preparations is more difficult

Method used

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  • Sustained release cubic liquid crystal liquid hard capsule and preparation method thereof
  • Sustained release cubic liquid crystal liquid hard capsule and preparation method thereof
  • Sustained release cubic liquid crystal liquid hard capsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] A slow-release cubic liquid crystal liquid hard capsule, consisting of a capsule shell and a capsule content, the capsule content is prepared from the following raw materials:

[0057]

[0058] The preparation of the sustained-release cubic liquid crystal liquid hard capsules of three prescriptions of the present embodiment comprises the following steps:

[0059] 1) Take the prescribed amount of GMO, heat and melt in a water bath at 40-45°C to obtain liquid GMO;

[0060] 2) Add the prescribed amount of drug powder meloxicam and corresponding auxiliary materials to the liquid GMO obtained in step 1), heat and stir in a water bath at 40-45°C for 1-6 hours, so that the system is in a uniform liquid state, and the contents of the liquid capsule are obtained;

[0061] 3) Fill the liquid capsule content obtained in step 2) into the upright hard capsule shell while it is hot, add a cap to seal it, and stand it upright overnight at room temperature to obtain the slow-release...

Embodiment 2

[0065] A slow-release cubic liquid crystal liquid hard capsule, consisting of a capsule shell and a capsule content, the capsule content is prepared from the following raw materials:

[0066]

[0067] The preparation method of the sustained-release cubic liquid crystal liquid hard capsules of the four prescriptions of this embodiment is the same as that of Embodiment 1.

[0068] The slow-release cubic liquid crystal liquid hard capsule prepared in this implementation is carried out release degree measurement, and assay method is the same as embodiment 1, and test result is as follows: figure 2 shown.

[0069] The inventor has found through a large number of experimental studies that the content of polyethylene glycol 1000 has a great influence on the release of the sustained-release cubic liquid crystal liquid hard capsule, and if the content is too high, the drug in the sustained-release cubic liquid crystal liquid hard capsule will appear to a certain extent. Burst rele...

Embodiment 3

[0071] A slow-release cubic liquid crystal liquid hard capsule, consisting of a capsule shell and a capsule content, the capsule content is prepared from the following raw materials:

[0072]

[0073] The preparation method of the sustained-release cubic liquid crystal liquid hard capsules of the four prescriptions of this embodiment is the same as that of Embodiment 1.

[0074] The slow-release cubic liquid crystal liquid hard capsules prepared by the present embodiment are tested for release, and the assay method is the same as in Example 1, and the test results are as follows: image 3 shown.

[0075] Depend on image 3 As a result, it can be seen that the slow-release cubic liquid crystal liquid hard capsules of the present embodiment all have a good sustained-release effect, and the addition of Tween 80 can further significantly improve the drug release degree of meloxicam sustained-release cubic liquid crystal liquid hard capsules, and further reduce the sudden relea...

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Abstract

The invention relates to a slow release cubic liquid crystal liquid hard capsule, which is composed of a capsule shell and a capsule content. The capsule content consists of a drug, glyceryl monooleate and an auxiliary material. The drug is a fat soluble drug or water soluble drug. The slow release cubic liquid crystal liquid hard capsule is prepared by: fusing and mixing the capsule content, and then conducting filling into the capsule shell while the capsule is hot. The slow release cubic liquid crystal liquid hard capsule has temperature sensitive characteristic, the capsule content is a solid at room temperature, can fuse and absorb water at body temperature so as to form a cubic liquid crystal, which can accommodate drugs of different natures, and also can play a role of slow release of drugs and improvement of drug stability.

Description

technical field [0001] The invention relates to the technical field of sustained release, in particular to a sustained release cubic liquid crystal liquid hard capsule and a preparation method thereof. Background technique [0002] Oral sustained-release preparations have a wide market and are an important direction for the development of pharmaceutical products at home and abroad. They are closely related to the industrial production of preparations and are expected to achieve a win-win situation for both therapeutic and industrial effects. [0003] The dosage forms of oral solid sustained-release preparations are mainly tablets and capsules. The sustained-release capsules can be divided into compound granule capsules, tablet core capsules, sustained-release pellet capsules, and skeleton-type granule capsules according to the dosage form of the filler in the capsule shell. In recent years, with the development of the pharmaceutical industry and the advancement of pharmaceut...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/52A61K31/5415A61K31/65A61K47/14A61K47/10A61K47/26
CPCA61K9/0002A61K9/4858A61K9/4866A61K31/5415A61K31/65
Inventor 潘昕黄莹梅丽玲
Owner SUN YAT SEN UNIV
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