Trans-4-aminoadamantan-1-ol hydrochloride synthesis technology

A technology for the synthesis of adamantanol and adamantanol, which is applied in the preparation of amino hydroxyl compounds, the preparation of organic compounds, organic chemistry, etc., can solve the problems of low production efficiency, high cost and complicated production process, etc. Work efficiency, the effect of overcoming many processes

Inactive Publication Date: 2016-06-22
QINGDAO SHOUGUAN ENTERPRISE MANAGEMENT CONSULTATION CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the present trans 4-amino-1-adamantanol hydrochloride synthesis process, the technical process is not easy to implement, and the trans 4-amino-1-adamantanol hydrochloride finished product purity of generation is low, and the reaction residue is not Can be recycled, the production process is complicated, the production efficiency is low and the cost is high, and it is not suitable for mass production

Method used

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Experimental program
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Embodiment

[0012] The trans 4-amino-1-adamantanol hydrochloride synthesis process of the present embodiment comprises the following steps:

[0013] (1) Using 5-hydroxy-2-adamantanone as raw material, prepare 5-hydroxy-2-adamantanone oxime by hydrochloric acid hydroxylamine oximation;

[0014] (2) 5-hydroxy-2-adamantanone oxime was reduced by Raney nickel hydrogenation to obtain 4-amino-1-adamantanol;

[0015] (3) 4-Amino-1-adamantanol was acidified to form a salt, and methanol recrystallized in three steps to obtain trans 4-amino-1-adamantanol hydrochloride;

[0016] (4) 5-Hydroxy-2-adamantanone oxime is in an alcoholic solvent, and at the same time add a Raney nickel catalyst with 50% weight of 5-hydroxy-2-adamantanone oxime, and feed hydrogen at a hydrogen pressure of 5MPa. 80 ° C for hydrogenation reduction reaction in the preparation of 4-amino-1-adamantanol.

[0017] The synthesis process of trans-4-amino-1-adamantanol hydrochloride does not require cumbersome post-reaction treatm...

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PUM

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Abstract

The invention discloses a trans-4-aminoadamantan-1-ol hydrochloride synthesis technology. The technology comprises that 4-amino-1-adamantanol is prepared from 5-hydroxy-2-adamantanone as a raw material through hydroxylamine hydrochloride oximation and Raney nickel hydrogenation reduction, the 4-amino-1-adamantanol is acidized to form a salt and trans-4-aminoadamantan-1-ol hydrochloride is prepared from the salt through methanol recrystallization three-step reactions. Compared with the prior art reported through the existing patent literature, the technology has the advantages of simple processes, raw material easy acquisition, low cost and high yield.

Description

technical field [0001] The invention belongs to the technical field of chemical synthesis, and in particular relates to a synthesis process of trans-type 4-amino-1-adamantanol hydrochloride. Background technique [0002] The synthesis process of trans 4-amino-1-adamantanol hydrochloride at least includes basic processes such as catalytic reaction and hydrogenation reaction. In the current trans 4-amino-1-adamantanol hydrochloride synthesis process, the technical process is not easy to implement, the trans 4-amino-1-adamantanol hydrochloride finished product purity is low, and the reaction residue is not Can be recycled, the production process is complicated, the production efficiency is low and the cost is high, and it is not suitable for large-scale production. Contents of the invention [0003] In order to overcome the above-mentioned technical problems existing in the prior art field, the purpose of the present invention is to provide a synthetic process for trans-...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C215/44C07C213/08
Inventor 李金婷
Owner QINGDAO SHOUGUAN ENTERPRISE MANAGEMENT CONSULTATION CO LTD
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