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Small-diameter artificial vascular graft preparation method based on electrostatic spinning

A technology for electrospinning and artificial blood vessels, which is used in the preparation of spinning solutions, blood vessels, textiles, and papermaking, etc., and can solve problems such as the inability to prepare small-diameter artificial blood vessels.

Active Publication Date: 2016-07-13
重庆高晋生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] In view of the above, the purpose of the present invention is to provide a small-caliber artificial blood vessel preparation method based on electrospinning, which is used to solve the problem that the prior art cannot prepare small-caliber artificial blood vessels with spiral groove walls

Method used

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  • Small-diameter artificial vascular graft preparation method based on electrostatic spinning
  • Small-diameter artificial vascular graft preparation method based on electrostatic spinning
  • Small-diameter artificial vascular graft preparation method based on electrostatic spinning

Examples

Experimental program
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Embodiment 1

[0041] Please refer to 1, which is a schematic diagram of the principle of a small-diameter artificial blood vessel preparation device based on electrospinning provided by the present invention, and the device will be described in detail below.

[0042] As shown in the figure, the device includes a high-voltage power supply device 1, a spinning solution injection device 2, a receiving device 4, and an injection slide control device 3, wherein the high-voltage power supply device 1 is used to output at least one high-voltage power supply including positive and negative polarities The spinning solution injection device 2 includes an injection device 22 for containing the spinning solution and an injection flow control device 23 for regulating and controlling the injection device 22 to output the spinning solution flow rate, and is used to inject the spinning solution in the injection device 22 according to the injection The regulation and control of the flow control device 23 is ...

Embodiment 2

[0061] In addition, in this embodiment, the present invention also provides a method for preparing artificial blood vessels through the device provided in Embodiment 1, please refer to Figure 5 , provides a flow chart of a method of using the device in Example 1 to realize the preparation of artificial blood vessels, and the implementation steps of the method will be described in detail below.

[0062]Step S10, use an electronic balance to weigh 0.4g of L-lactic acid and ε-caprolactone copolymer (P(LLA-CL)) [full name: Poly(L-lactide-co-epsilon-caprolactone)], the molar ratio is 50 :50, dissolved in 5ml of hexafluoroisopropanol (linear molecular formula: (CF3) 2CHOH), stirred and oscillated by a magnetic stirrer until the dissolution is complete, generally the rotating speed of the magnetic stirrer is set to 300rpm, and the concentration obtained is 8% ( g / ml) of the electrospinning solution;

[0063] Step S20, put the electrospinning solution into the spinning solution inje...

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Abstract

The invention provides a small-diameter artificial vascular graft preparation method based on electrostatic spinning. The method includes: preparing a polymer spinning solution; filling a spinning solution injection device with the prepared spinning solution and regulating a spinning solution flow speed; selecting a corresponding receiving bar according to preparation requirements and mounting the receiving bar on a rotary receiving device; adjusting a receiving distance; enabling the receiving bar to ground, turning on a high-voltage static generator to regulate static spinning voltage, and providing a high field between a nozzle and the receiving bar through a high-voltage power source; powering off after preparation is completed, demounting the receiving bar and taking down an artificial vascular graft prepared by spinning. The small-diameter artificial vascular graft preparation method based on electrostatic spinning is simple, and the inner wall of the artificial vascular graft prepared based on electrostatic spinning is provided with a spiral groove, so that flow wall shear force in the artificial vascular graft can be enhanced, harmful substances deposited in blood on the artificial vascular graft wall are reduced, and long-term graft patency of the artificial vascular graft, particularly the small-diameter artificial vascular graft, is improved.

Description

technical field [0001] The invention relates to the field of preparation of artificial blood vessels, in particular to a method for preparing small-diameter artificial blood vessels based on electrospinning. Background technique [0002] In recent years, the incidence of coronary heart disease, atherosclerosis and other diseases has been increasing day by day, and artificial vascular transplantation has attracted much attention as the main means of treating vascular diseases. Electrospinning square technology was invented by American Formhals (Formhals) in 1934 and has been widely used in the preparation of tissue engineering scaffolds. Artificial blood vessels made of electrospun fibers have high porosity and large specific surface area. , high fiber fineness and uniformity, large aspect ratio, etc. These excellent properties that cannot be obtained by traditional methods endow electrospun fibers with a wide range of application prospects. In addition, electrospinning t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): D01D5/00D01D1/02A61F2/06
CPCA61F2/06D01D1/02D01D5/0061D01D5/0069D01D5/0076
Inventor 叶志义王贵学董文秀吴海德席亚东
Owner 重庆高晋生物科技有限公司
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