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A preparation method of a medicinal composition for treating stroke

A composition and drug technology, applied in the field of Tibetan medicine, can solve the problems of reducing the extraction rate of total flavonoids and total alkaloids, affecting the extraction effect of medicinal components, and unstable quality

Active Publication Date: 2019-06-04
SHANDONG JINHE DRUG RES DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] The prescription is 150 parts by weight of artificial bezoar, 150 parts by weight of geranium yellow, 75 parts by weight of pearl, 25 parts by weight of saffron, 25 parts by weight of artificial musk, 75 parts by weight of jujube, 75 parts by weight of Corydalis cypress, and 50 parts by weight of grass fruit The pharmaceutical composition of 75 parts by weight of Myrobalan is a prescription prepared by the inventor according to Zhenlong Xingnao Capsules, which has a good curative effect on stroke caused by phlegm and blood stasis blocking collaterals. Its preparation method is that the medicinal materials are directly pulverized, but the method The dosage is too large, the quality is unstable, and the preparation level is low
For formulas containing similar medicinal materials, the conventional method of adding water or ethanol is commonly used in the prior art, but usually extraction is performed separately or all medicinal materials are extracted together, which may affect the extraction effect of medicinal ingredients
The study found that the extraction rate of total flavonoids and total alkaloids was greatly reduced when Guangzao and Corydalis sergei were co-extracted

Method used

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  • A preparation method of a medicinal composition for treating stroke
  • A preparation method of a medicinal composition for treating stroke
  • A preparation method of a medicinal composition for treating stroke

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0029] Experimental Example 1 Effects of Different Medicinal Material Combinations on Extraction

[0030] The study found that jujube and Corydalis sylvestris interacted with each other when they were extracted together, and the extraction rate of total flavonoids and total alkaloids was greatly reduced. For this reason, the following experiments were carried out to investigate the effects of different combinations of medicinal materials on extraction.

[0031] 1 Materials and Equipment

[0032] UV-2450 Shimadzu ultraviolet spectrophotometer; KQ5200B ultrasonic cleaner (Kunshan Ultrasonic Instrument Co., Ltd.); Shimadzu AUW220D electronic balance (Shimadzu Corporation of Japan); Provided by Jinhe Tibetan Medicine Co., Ltd., batch 20131209); the rest of the reagents are of analytical grade.

[0033] 2 methods

[0034] In the pharmaceutical composition, Jujube, Corydalis, Tsaoguo, and Myrobalan usually need to be extracted, and the active ingredients of Tsaoguo are volatile oi...

experiment example 2

[0056] Experimental Example 2 Selection of Combination Ratio of Myrobalan, Jujube and Viola Corydalis

[0057] In the following, the effects on the transfer rate of total flavonoids and total alkaloids were further investigated when the two medicinal materials were combined and extracted with different ratios of Myrobalan.

[0058] 1 Materials and Equipment

[0059] UV-2450 Shimadzu ultraviolet spectrophotometer; KQ5200B ultrasonic cleaner (Kunshan Ultrasonic Instrument Co., Ltd.); Shimadzu AUW220D electronic balance (Shimadzu Corporation of Japan); Provided by Jinhe Tibetan Medicine Co., Ltd., batch 20131209); the rest of the reagents are of analytical grade.

[0060] 2 methods

[0061] Take Guangzao, Corydalis serrata, and Myrobalan, and combine them according to Table 3.

[0062] Each group was extracted twice by adding water. For the first time, water with a volume 10 times the weight of the medicinal material was added for 2 hours, and for the second time, water with a...

experiment example 3

[0074] Experimental example 3 optimization parameter verification experiment

[0075] 1 Materials and Equipment

[0076] UV-2450 Shimadzu ultraviolet spectrophotometer; KQ5200B ultrasonic cleaner (Kunshan Ultrasonic Instrument Co., Ltd.); Shimadzu AUW220D electronic balance (Shimadzu Corporation of Japan); Provided by Jinhe Tibetan Medicine Co., Ltd., batch 20131209); the rest of the reagents are of analytical grade.

[0077] 2 methods

[0078] Take Guangzao, Corydalis serrata, and myrobalan, and combine them according to Table 5.

[0079] Each group was extracted twice by adding water. For the first time, water with a volume 10 times the weight of the medicinal material was added for 2 hours, and for the second time, water with a volume 8 times the weight of the medicinal material was added for 2 hours. The extracts were combined and concentrated under reduced pressure to 1g of medicinal materials / ml of medicinal liquid, to obtain concentrated solutions of extracts from di...

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Abstract

The invention discloses a preparation method of a pharmaceutical composition for the treatment of stroke. The invention employs a combined extraction method of 75g of fructus choerospondiatis and 25-65g of terminaliae billericae, and a combined extraction method of 75g of Corydalis impatiens and 10-50g of 13. The pharmaceutical composition has total flavonoids and total alkaloid extraction rates increased by 10% compared with individual extraction; especially combined extraction of 55g of terminaliae billericae and 75g of Corydalis impatiens, and combined of 20g of terminaliae billericae and 75g of Corydalis impatiens achieve both highest transfer rates of total flavonoids and alkaloids.

Description

technical field [0001] The invention relates to a preparation method of a medicinal composition for treating stroke, belonging to the technical field of Tibetan medicine. Background technique [0002] The prescription is 150 parts by weight of artificial bezoar, 150 parts by weight of geranium yellow, 75 parts by weight of pearl, 25 parts by weight of saffron, 25 parts by weight of artificial musk, 75 parts by weight of jujube, 75 parts by weight of Corydalis cypress, and 50 parts by weight of grass fruit The pharmaceutical composition of 75 parts by weight of Myrobalan is a prescription prepared by the inventor according to Zhenlong Xingnao Capsules, which has a good curative effect on stroke caused by phlegm and blood stasis blocking collaterals. Its preparation method is that the medicinal materials are directly pulverized, but the method The dosage is too large, the quality is unstable, and the preparation level is low. For formulas containing similar medicinal material...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9064A61P9/10A61K35/618A61K35/413A61K35/32
Inventor 杨文钰姬涛李怀平魏永义赵丽丽
Owner SHANDONG JINHE DRUG RES DEV