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Aminolevulinic acid hydrochloride temperature-sensitive in-situ gel preparation and method for preparing same

An aminolevulinic acid hydrochloride, temperature-sensitive technology, applied in pharmaceutical formulations, aerosol delivery, medical preparations with inactive ingredients, etc., can solve the problems of low bioavailability and inconvenient use of 5-ALA preparations, To achieve the effect of convenient large-scale production, convenient use and broad clinical application prospects

Active Publication Date: 2016-07-20
FUZHOU GENERAL HOSPITAL OF NANJING MILITARY COMMAND P L A
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The purpose of the present invention is to provide a temperature-sensitive in-situ gel preparation of aminolevulinic acid hydrochloride, which can solve many problems such as low bioavailability and inconvenient use of existing 5-ALA preparations, and has broad clinical application prospects

Method used

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  • Aminolevulinic acid hydrochloride temperature-sensitive in-situ gel preparation and method for preparing same
  • Aminolevulinic acid hydrochloride temperature-sensitive in-situ gel preparation and method for preparing same
  • Aminolevulinic acid hydrochloride temperature-sensitive in-situ gel preparation and method for preparing same

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Effect test

Embodiment 1

[0025]

[0026] The preparation method of the gel matrix is ​​as follows: take the prescribed amount of ethylparaben, add it to glycerin, heat to dissolve, add propylene glycol, azone and part of purified water successively after natural cooling, and then add the prescribed amount of poloxamer 188 and poloxamer Slowly add Sharm 407 while stirring, place it at 2~8°C until it becomes a clear, lump-free, uniformly dispersed transparent solution, and add purified water to the total amount.

Embodiment 2

[0028]

[0029] The preparation method of the gel matrix is ​​as follows: take the prescribed amount of ethylparaben, add part of the purified water, heat and dissolve, add sorbitol and azone in turn after natural cooling, and dissolve the prescribed amount of poloxamer 188 and chitosan Slowly add sugar while stirring, place it at 2~8°C until it becomes a clear, lump-free, uniformly dispersed transparent solution, add purified water to reach the total amount.

Embodiment 3

[0031]

[0032] The preparation method of the gel matrix is ​​as follows: take the prescribed amount of benzoic acid, add part of the purified water, heat and dissolve, add propylene glycol and dimethyl sulfoxide in turn after natural cooling, and dissolve the prescribed amount of poloxamer 407 and carbopol Slowly add while stirring, place at 2~8°C until it becomes a transparent solution with no lumps and evenly dispersed, and add purified water to the total amount.

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Abstract

The invention discloses an aminolevulinic acid hydrochloride temperature-sensitive in-situ gel preparation and belongs to the technical field of medicinal preparations. The preparation consists of aminolevulinic acid hydrochloride solid powder and a gel substrate. During use, the aminolevulinic acid hydrochloride solid powder and the gel substrate are uniformly mixed and then are spread. The invention firstly prepares aminolevulinic acid hydrochloride into temperature-sensitive in-situ gel, the preparation is in a liquid state when the preparation is out of a body, the dose is easy to control, semisolid gel can be quickly formed at an administrated position after administration, the retention time is long, the biocompatibility is good, the use is facilitated, the problems such as low biological utilization rate and inconvenience in use of 5-ALA preparations are solved, and the preparation is applicable to the treatment of various skin diseases such as acnes and actinic keratosis and has a wide clinical application prospect.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a temperature-sensitive in-situ gel preparation of aminolevulinic acid hydrochloride. Background technique [0002] Photodynamic therapy (Photodynamic therapy, PDT) was created in the 1970s. It is a clinical method that irradiates a photosensitizer with a specific wavelength of light to cause a photochemical reaction to destroy diseased tissue to achieve therapeutic purposes. It was mainly used in the treatment of tumors at first. It is found that it also has significant therapeutic effects in the treatment of non-neoplastic skin diseases, and the treatment of certain proliferative diseases, viral diseases and inflammatory diseases, such as acne and actinic keratosis. [0003] 5-aminolevulinic acid (5-ALA) is also known as 5-amino-4-ketovaleric acid, and its molecular formula is C 5 h 9 NO 3 , the molecular weight is 131.13, and its chemical str...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61K9/06A61K47/34A61K47/36A61K47/32A61P17/00A61P17/10
Inventor 宋洪涛曾令军庄珊珊黄爱文刘志宏张晶
Owner FUZHOU GENERAL HOSPITAL OF NANJING MILITARY COMMAND P L A
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