Aminolevulinic acid hydrochloride temperature-sensitive in-situ gel preparation and method for preparing same
An aminolevulinic acid hydrochloride, temperature-sensitive technology, applied in pharmaceutical formulations, aerosol delivery, medical preparations with inactive ingredients, etc., can solve the problems of low bioavailability and inconvenient use of 5-ALA preparations, To achieve the effect of convenient large-scale production, convenient use and broad clinical application prospects
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[0024] Example 1
[0025]
[0026] The preparation method of the gel matrix is: take the prescription amount of ethyl paraben, add it to glycerin, heat to dissolve, add propylene glycol, azone and part of purified water after natural cooling, and then add the prescription amount of poloxamer 188 and poloxamer Sham 407 is slowly added while stirring, and placed at 2~8°C until it is a clear, clump-free, and uniformly dispersed transparent solution. Add purified water to the total amount.
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[0027] Example 2
[0028]
[0029] The preparation method of the gel matrix is: take the prescription amount of ethyl paraben, add it into partially purified water, heat to dissolve, add sorbitol and azone in sequence after natural cooling, and then dissolve the prescription amount of poloxamer 188 and chitosan The sugar is slowly added while stirring, and placed at 2~8°C until it is a clear, lumpy, and uniformly dispersed transparent solution. Add purified water to the total amount.
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[0030] Example 3
[0031]
[0032] The preparation method of the gel matrix is: take the prescription amount of benzoic acid, add it into partially purified water, heat to dissolve, add propylene glycol and dimethyl sulfoxide in sequence after natural cooling, and then dissolve the prescription amount of poloxamer 407 and carbopol. Slowly add it while stirring. Place it at 2~8℃ until it is a clear, lumpy, and uniformly dispersed transparent solution. Add purified water to the total amount.
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