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Determination of plasma concentrations of sababicin and its metabolite m3 in human plasma by uplc-ms/ms

A technology of sabarubicin and metabolites, which is applied in the field of determination of the concentration of sabarubicin and C13 alcohol metabolite M3 in human plasma, can solve the problems of low sensitivity and cannot be detected at the same time, and achieves high sensitivity and good repeatability. , sample processing simple effect

Active Publication Date: 2019-01-18
CANCER INST & HOSPITAL CHINESE ACADEMY OF MEDICAL SCI
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Problems solved by technology

It has been reported that the method cannot detect the C13 alcohol metabolite M3 at the same time, the sensitivity is low, and it is not suitable for the detection of large quantities of samples for clinical pharmacokinetic research

Method used

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  • Determination of plasma concentrations of sababicin and its metabolite m3 in human plasma by uplc-ms/ms
  • Determination of plasma concentrations of sababicin and its metabolite m3 in human plasma by uplc-ms/ms
  • Determination of plasma concentrations of sababicin and its metabolite m3 in human plasma by uplc-ms/ms

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Embodiment Construction

[0027] In order to describe the present invention more clearly, the specific implementation manners of the present invention will be described in more detail below through specific implementation examples. However, it should be understood that the specific implementation examples described below are only used to illustrate the present invention, and are not used to limit the present invention, and the materials, reagents, instruments and operating conditions used are only representative and are not intended to be used for the present invention. limited to the cases listed. Those skilled in the art can make changes and improvements to the present invention without departing from the protection scope defined by the claims of the present invention by reading the following descriptions, and these changes and improvements are also within the protection scope of the present invention.

[0028] 1. The inventors have established an ultra-high performance liquid chromatography-mass spe...

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Abstract

The invention relates to an ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS / MS) method for determining plasma concentration of doxorubicin analogue and metabolite M3 in human plasma and provides a method for determining the concentration of doxorubicin analogue and C13 alcohol metabolite M3 in human plasma through UPLC-MS / MS. The method is carried out with formic acid water-acetonitrile as a mobile phase. The method for detecting the doxorubicin analogue and the metabolite M3 provided by the invention is high in sensitivity and good in repeatability, and can meet the requirements of quantitative analysis of clinical pharmacokinetic biological samples for treating malignant parenchymatous tumors by the doxorubicin analogue.

Description

technical field [0001] The present invention relates to a method for detecting the concentration of a drug in human plasma. Specifically, the present invention relates to a method for determining the concentration of sababicin and C13 alcohol metabolite M3 in human plasma by ultra-high performance liquid chromatography tandem mass spectrometry (UPLC-MS / MS). Background technique [0002] introduction [0003] Sababicin belongs to anthracyclines, a new type of drug synthesized by Italian Menarini Pharmaceutical Company by extending and modifying carbohydrates, which has stronger drug efficacy and lower cardiotoxicity [11,12] . Animal experiments show that sabarubicin has a stronger inhibitory effect on tumors from different tissues than its similar drug doxorubicin [13] . Moreover, European phase I and II clinical trials have initially verified the safety and tolerance of sababicin in humans, proving that sababicin has a good curative effect on ovarian cancer and lung canc...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/02
CPCG01N30/02G01N2030/027
Inventor 石远凯韩晓红张妍
Owner CANCER INST & HOSPITAL CHINESE ACADEMY OF MEDICAL SCI
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