Preparation method and application of anti-lipid peroxide

A technology for peroxides and lipids, which is applied in the field of preparation of anti-lipid peroxides, can solve the problems of long preparation time, insufficiently mild reaction conditions, insufficient yield, etc., and achieves simple preparation method, short time-consuming, and chromatography. good effect

Inactive Publication Date: 2016-08-03
周礼红
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, there are few methods for preparing anti-lipid peroxides. The existing reaction conditions for anti-lipid peroxides are still not gentle enough, and it takes a long time to prepare. still not high enough

Method used

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  • Preparation method and application of anti-lipid peroxide
  • Preparation method and application of anti-lipid peroxide
  • Preparation method and application of anti-lipid peroxide

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Example 1: A method for preparing anti-lipid peroxides, including the step of extracting fermentation samples of Monascus as raw materials.

Embodiment 2

[0044] Embodiment 2: A use of anti-lipid peroxide, said anti-lipid peroxide is used in the preparation of anti-lipid peroxide active drugs.

Embodiment 3

[0045] Example 3: A preparation method of anti-lipid peroxide, including the following steps: take a dried Monascus fermented sample, add extraction solvent, extract by extraction to obtain a crude extract, and then use column chromatography to elute the crude The product is extracted to obtain a purified eluent, and the purified eluent is subjected to silica gel thin layer chromatography, and the eluents of the same silica gel thin layer chromatography result are combined to obtain the anti-lipid peroxide.

[0046] A use of anti-lipid peroxide, which is used in the preparation of anti-lipid peroxide active drugs.

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PUM

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Abstract

The invention discloses a preparation method of anti-lipid peroxide. The preparation method comprises the following steps of: taking a dry monascus fermentation sample, adding an extraction solvent, obtaining a crude extract through extraction by adopting an extraction method, then eluting the crude extract by adopting column chromatography to obtain purified eluent, carrying out silica gel thin-layer chromatography on the purified eluent and combining the eluent with the same silica gel thin-layer chromatography result, thus obtaining anti-lipid peroxide. The preparation method has the beneficial effects that the method for preparing anti-lipid peroxide by using monascus as the raw material is provided for the first time; the crude extract of the monascus sample is firstly extracted and the best column chromatography eluent is further screened according to polar distribution and the solubility in different solvents to effectively separate and purify anti-lipid peroxide; the preparation method is simple, is easy to achieve, consumes short time, is accessible in raw materials and low in cost and achieves volume production of anti-lipid peroxide.

Description

Technical field [0001] The invention relates to the technical field of compound extraction, in particular to a preparation method and application of anti-lipid peroxide. Background technique [0002] Free radicals refer to atoms or molecules with unpaired electrons in the outer orbital. They are extremely unstable and very lively. They are the products of normal aerobic metabolism of cells, and most of them exist in the form of reactive oxygen species (ROS). Once free radicals are generated, most of the free radicals will be eliminated by the antioxidant defense system (enzymes and non-enzyme molecules) in the cell. The maintenance of the balance between free radicals and the antioxidant defense system is an essential condition for the normal functioning of organisms. ROS is beneficial to the body at low or medium concentrations. It is involved in the signal transduction and regulation of cells in physiological processes. However, when ROS is produced too much or the function o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07J9/00A61K31/575A61P1/04A61P35/00
CPCC07J9/00A61K31/575A61K36/062
Inventor 周礼红侯素媛
Owner 周礼红
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