Fixed damage model cutter for liver of rat

Abstract

The invention discloses a fixed damage model cutter for the liver of a rat. The fixed damage model cutter comprises an annular bottom plate and an annular knife arranged in the center of the annular bottom plate and extending out of the annular bottom plate, wherein air holes used for air exhaust and steel wires used for cutting during rotation are formed on the annular bottom plate. According to the fixed damage model cutter for the liver of the rat, few tools are used, manual damage except a research object is reduced, the liver tissue with a fixed size can be cut, system errors are small, the number of experimental animals is further reduced, the cutter is convenient to operate, the operation time is shortened, and experiment and comparison results are more accurate.

Description

technical field [0001] The invention relates to the technical field of medical devices, in particular to a rat liver fixed injury model cutter. Background technique [0002] In order to make the comparison between different hemostatic products and schemes more meaningful, fixed research objects and fixed-sized injury models are often set up in experiments. In many literatures, scissors and scalpels are commonly used tools for the manufacture of regular bleeding injury models. However, this The damage models produced by this kind of method are quite different and cannot be used for accurate assessment. For example, in the 2000 experiment by Davidson, BR, and others, tearing the animal's liver by hand to damage it caused serious damage to tissues other than the liver, and the accuracy was not good enough, which may affect the experimental results. Even in 1983, Heinz Jakob et al. mentioned in the experiment that a hole with a diameter of 1 cm and a thickness of 2 mm was made ...

AI Technical Summary

Problems solved by technology

[0002] In order to make the comparison between different hemostatic products and schemes more meaningful, fixed research objects and fixed-sized injury models are often set up in experiments. In many literatures, scissors and scalpels are commonly used tools for the manufacture of regular bleeding injury models. However, this The damage models produced by similar methods are quite different and cannot be used for accurate assessment

For example, in the 2000 experiment by Davidson, BR, and others, they used hand tearing to create animal liver damage. This kind of practice caused serious damage to tissues other than liver damage, and the accuracy was not good, which may affect the experimental results.

Even in 1983, Heinz Jakob and others mentioned in the experiment that a hole with a diameter of 1 cm and a thickness of 2 mm was made on the left lobe of the rat liver, but the specific steps and detailed explanations were not mentioned.

In the comparison of different hemostatic products and solutions, the requirements for the determination of the hemostasis time are quite high. Too complicated damage tools and methods are not conducive to the measurement and recording of the hemostasis time. As a result, adhesion is formed. If the experiment is designed to evaluate the adhesion of different hemostatic products and solutions after a certain period of time, the adhesion caused by the long operation time and not timely hemostasis will have a great impact on the experimental results.

For example, in the research of a new type of fibrin sealant by Davidson, BR and others in 2000, a wedge-shaped injury of the liver was created. After the injury, the large blood vessel with a larger diameter in the cut surface needs to be ligated, and secondly, the diameter of the cut surface should be measured. The area and the weight of the removed tissue, the steps are cumbersome, and the recording of the hemostasis time is extremely inaccurate

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