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Kit and method for detecting sensitivity to xanthine oxidase inhibitor

A xanthine oxidase and inhibitor technology, applied in the field of kits for detecting allergy to xanthine oxidase inhibitors, can solve problems such as difficulty in guaranteeing allergic reactions, and achieve the effects of high sensitivity and specificity

Inactive Publication Date: 2016-08-17
GUANGZHOU HEKANG MEDICAL TECH CO LTD +2
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The kit analyzes the HLA-B*5801 gene by detecting the fluorescent quantitative PCR dye method combined with the melting curve technology. Anaphylaxis in negative patients

Method used

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  • Kit and method for detecting sensitivity to xanthine oxidase inhibitor
  • Kit and method for detecting sensitivity to xanthine oxidase inhibitor
  • Kit and method for detecting sensitivity to xanthine oxidase inhibitor

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Embodiment Construction

[0028] In order to facilitate the understanding of the present invention, the present invention will be described more fully below with reference to the associated drawings. Preferred embodiments of the invention are shown in the accompanying drawings. However, the present invention can be embodied in many different forms and is not limited to the embodiments described herein. On the contrary, the purpose of providing these embodiments is to make the understanding of the disclosure of the present invention more thorough and comprehensive.

[0029]Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the technical field of the invention. The terminology used herein in the description of the present invention is only for the purpose of describing specific embodiments, and is not intended to limit the present invention. As used herein, the term "and / or" includes any and all combinations ...

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Abstract

The invention relates to a kit and a method for detecting sensitivity to a xanthine oxidase inhibitor. The kit comprises an amplification primer, a magnetic microbead and a detection reagent, wherein a capture probe is fixed on the surface of the magnetic microbead. Through the kit and the method for detecting sensitivity to the xanthine oxidase inhibitor, the specific amplification primer and the capture probe are designed according to 12 SNP sites which are highly sensitive to xanthine oxidase; the types of the 12 SNP sites can be subjected to typing detection; the specificity is high; the capture probe is fixed by the magnetic microbead; the detection is carried out by hybridization reaction of the capture probe and the amplification product; the sensitivity is high; 12 SNP types in a to-be-detected DNA sample can be relatively fast detected.

Description

technical field [0001] The invention relates to the field of biochemical detection, in particular to a kit and method for detecting hypersensitivity to xanthine oxidase inhibitors. Background technique [0002] Hyperuricemia is a metabolic disease caused by abnormal purine metabolism, excessive production of blood uric acid or excretion disorder. It is not only the main risk factor for gout, but also an important part of metabolic syndrome. Hyperuricemia affects the functions of the heart, kidneys and other organs, and is an independent risk factor for hypertension and coronary heart disease, as well as an important risk factor for chronic renal insufficiency, causing serious harm to human health. [0003] Xanthine oxidase (Xanthine oxidase, XOD) is an important enzyme in the process of purine catabolism, which catalyzes the conversion of hypoxanthine into xanthine and the oxidation process of uric acid from xanthine, which is related to the hyperuricemia caused by the incre...

Claims

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Application Information

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IPC IPC(8): C12Q1/68
CPCC12Q1/6858C12Q1/6883C12Q2600/106C12Q2600/156C12Q2600/16C12Q2531/113C12Q2537/143C12Q2563/143C12Q2563/149C12Q2565/519
Inventor 杜予和陈萌萌杨剑锋曾宪鍫马淑雯
Owner GUANGZHOU HEKANG MEDICAL TECH CO LTD
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