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Molecular diagnostic test for oesophageal cancer

A technique for esophageal adenocarcinoma and test samples, which can be used in the determination/inspection of microorganisms, digestive system, antitumor drugs, etc., and can solve problems such as insufficient indication of responsiveness to PARP-1 inhibitors

Inactive Publication Date: 2016-08-17
ALMAC DIAGNOSTICS LIMITED
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  • Abstract
  • Description
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  • Application Information

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Problems solved by technology

Recent studies have shown that triple-negative status of breast tumors may indicate responsiveness to combination therapy including PARP-1 inhibitors, but may not be sufficient to indicate responsiveness to individual PARP-1 inhibitors (O'Shaughnessy et al. ,2011)

Method used

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  • Molecular diagnostic test for oesophageal cancer
  • Molecular diagnostic test for oesophageal cancer
  • Molecular diagnostic test for oesophageal cancer

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Embodiment Construction

[0031] Unless defined otherwise, technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. Although any methods, devices and materials similar or equivalent to those described herein can be used in the practice or testing of the present invention, the preferred methods, devices and materials are now described.

[0032] All publications, published patent documents, and patent applications cited in this application are indicative of the state of the art to which this application pertains. All publications, published patent documents, and patent applications cited herein are incorporated by reference to the same extent as if each individual publication, published patent document, or patent application was specifically and individually indicated to be incorporated by reference. way incorporated into this article.

[0033] The articles "a" and "an" are used herein to refer to one or ...

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Abstract

Methods and compositions are provided for the identification of a molecular diagnostic test for oesophageal adenocarcinoma (OAC). The test defines a novel DNA damage repair deficient molecular subtype and enables classification of a patient within this subtype. The present invention can be used to determine whether patients with OAC are clinically responsive or non-responsive to a therapeutic regimen prior to administration of any chemotherapy. This test may be used with different drugs that directly or indirectly affect DNA damage or repair, such as many of the standard cytotoxic chemotherapeutic drugs currently in use. In particular, the present invention is directed to the use of certain combinations of predictive markers, wherein the expression of the predictive markers correlates with responsiveness or non-responsiveness to a therapeutic regimen.

Description

field of invention [0001] The present invention relates to molecular diagnostic tests for predicting the responsiveness of esophageal cancer to specific treatments, including the use of DNA damage repair deficient subtypes. The present invention includes the generation and use of various classifiers (classifiers) derived from the identification of this subtype in esophageal cancer patients, especially esophageal adenocarcinoma (OAC) patients, such as the 44-gene classifier model. used to identify the DNA damage repair deficient molecular subtype. One application is to stratify response and select patients for esophageal cancer treatment drug classes, including agents that cause DNA damage and DNA repair-targeted therapies. The present invention provides tests that can guide traditional treatment selection and select patient populations for enrichment strategies during clinical trial evaluation of novel therapeutics. DNA repair deficient subtypes can be identified, for exampl...

Claims

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Application Information

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IPC IPC(8): C12Q1/68
CPCC12Q2600/106C12Q2600/158C12Q1/6886A61P1/04A61P35/00C12Q2600/118C12Q1/68
Inventor K·基廷L·希尔S·德哈罗E·奥布莱恩T·达维森P·哈金R·肯尼迪J·奥唐奈
Owner ALMAC DIAGNOSTICS LIMITED
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